Polymorphisms in the Gene That Encodes the Iron Transport Protein Ferroportin 1 Influence Susceptibility to Tuberculosis
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Polymorphisms in the Gene That Encodes the Iron Transport Protein Ferroportin 1 Influence Susceptibility to Tuberculosis
| Title: | Polymorphisms in the Gene That Encodes the Iron Transport Protein Ferroportin 1 Influence Susceptibility to Tuberculosis |
| Author: |
Baker, Meghan Ann; Wilson, Douglas; Wallengren, Kristina; Sandgren, Andreas; Iartchouk, Oleg; Broodie, Nisha Monique; Goonesekera, Sunali D.; Sabeti, Pardis Christine; Murray, Megan Blanche
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Baker, Meghan Ann, Douglas Wilson, Kristina Wallengren, Andreas Sandgren, Oleg Iartchouk, Nisha Broodie, Sunali D. Goonesekra, Pardis C Sabeti, and Megan B. Murray. 2012. Polymorphisms in the gene that encodes the iron transport protein ferroportin 1 influence susceptibility to suberculosis. Journal of Infectious Disease 205(7): 1043-1047. |
| Full Text & Related Files: |
2012-Baker-JID-TB.doc (126.4Kb; Microsoft Word) 
2012-Baker-JID-TB.pdf (181.1Kb; PDF) 
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| Abstract: | Background: We studied the association between iron intake and polymorphisms in the iron transporter gene, SLC40A1, and the risk of tuberculosis. Methods: We compared iron intake, the frequency of SLC40A1 mutations, and interactions between these variables among 98 TB patients and 125 controls in Kwazulu-Natal, South Africa. Results: Four SLC40A1 SNPs were associated with an increased risk of tuberculosis and one with reduced risk. We also found a gene-environment interaction for four non-exonic SNPs and iron intake. Conclusions: This pilot study demonstrated an association between polymorphisms in SLC40A1 and tuberculosis and provided evidence for an interaction between dietary iron and SLC40A1. |
| Published Version: | doi:10.1093/infdis/jis026 |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pubmed/22357659 |
| Terms of Use: | This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:9891821 |
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Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University
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