Polymorphisms in the Gene That Encodes the Iron Transport Protein Ferroportin 1 Influence Susceptibility to Tuberculosis

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Polymorphisms in the Gene That Encodes the Iron Transport Protein Ferroportin 1 Influence Susceptibility to Tuberculosis

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Title: Polymorphisms in the Gene That Encodes the Iron Transport Protein Ferroportin 1 Influence Susceptibility to Tuberculosis
Author: Baker, Meghan Ann; Wilson, Douglas; Wallengren, Kristina; Sandgren, Andreas; Iartchouk, Oleg; Broodie, Nisha Monique; Goonesekera, Sunali D.; Sabeti, Pardis Christine; Murray, Megan Blanche

Note: Order does not necessarily reflect citation order of authors.

Citation: Baker, Meghan Ann, Douglas Wilson, Kristina Wallengren, Andreas Sandgren, Oleg Iartchouk, Nisha Broodie, Sunali D. Goonesekra, Pardis C Sabeti, and Megan B. Murray. 2012. Polymorphisms in the gene that encodes the iron transport protein ferroportin 1 influence susceptibility to suberculosis. Journal of Infectious Disease 205(7): 1043-1047.
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Abstract: Background: We studied the association between iron intake and polymorphisms in the iron transporter gene, SLC40A1, and the risk of tuberculosis. Methods: We compared iron intake, the frequency of SLC40A1 mutations, and interactions between these variables among 98 TB patients and 125 controls in Kwazulu-Natal, South Africa. Results: Four SLC40A1 SNPs were associated with an increased risk of tuberculosis and one with reduced risk. We also found a gene-environment interaction for four non-exonic SNPs and iron intake. Conclusions: This pilot study demonstrated an association between polymorphisms in SLC40A1 and tuberculosis and provided evidence for an interaction between dietary iron and SLC40A1.
Published Version: doi:10.1093/infdis/jis026
Other Sources: http://www.ncbi.nlm.nih.gov/pubmed/22357659
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:9891821

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  • FAS Scholarly Articles [6463]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University
 
 

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