Polymorphisms in the Gene That Encodes the Iron Transport Protein Ferroportin 1 Influence Susceptibility to Tuberculosis
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| dc.contributor.author |
Baker, Meghan Ann
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| dc.contributor.author |
Wilson, Douglas |
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| dc.contributor.author |
Wallengren, Kristina |
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| dc.contributor.author |
Sandgren, Andreas |
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| dc.contributor.author |
Iartchouk, Oleg |
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| dc.contributor.author |
Broodie, Nisha Monique
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| dc.contributor.author |
Goonesekera, Sunali D. |
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| dc.contributor.author |
Sabeti, Pardis Christine
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| dc.contributor.author |
Murray, Megan Blanche
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| dc.date.accessioned |
2012-11-13T19:02:52Z |
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| dc.date.issued |
2012 |
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| dc.identifier.citation |
Baker, Meghan Ann, Douglas Wilson, Kristina Wallengren, Andreas Sandgren, Oleg Iartchouk, Nisha Broodie, Sunali D. Goonesekra, Pardis C Sabeti, and Megan B. Murray. 2012. Polymorphisms in the gene that encodes the iron transport protein ferroportin 1 influence susceptibility to suberculosis. Journal of Infectious Disease 205(7): 1043-1047. |
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| dc.identifier.issn |
0022-1899 |
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| dc.identifier.issn |
1537-6613 |
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| dc.identifier.uri |
http://nrs.harvard.edu/urn-3:HUL.InstRepos:9891821 |
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| dc.description.abstract |
Background: We studied the association between iron intake and polymorphisms in the iron transporter gene, SLC40A1, and the risk of tuberculosis. Methods: We compared iron intake, the frequency of SLC40A1 mutations, and interactions between these variables among 98 TB patients and 125 controls in Kwazulu-Natal, South Africa. Results: Four SLC40A1 SNPs were associated with an increased risk of tuberculosis and one with reduced risk. We also found a gene-environment interaction for four non-exonic SNPs and iron intake. Conclusions: This pilot study demonstrated an association between polymorphisms in SLC40A1 and tuberculosis and provided evidence for an interaction between dietary iron and SLC40A1. |
en_US |
| dc.description.sponsorship |
Organismic and Evolutionary Biology |
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| dc.language.iso |
en_US |
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| dc.publisher |
Oxford University Press |
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| dc.relation.isversionof |
doi:10.1093/infdis/jis026 |
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| dc.relation.hasversion |
http://www.ncbi.nlm.nih.gov/pubmed/22357659 |
en_US |
| dash.license |
OAP |
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| dc.subject |
SLC40A1 |
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| dc.subject |
ferroportin |
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| dc.subject |
FPN1 |
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| dc.subject |
tuberculosis |
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| dc.subject |
mycobacterium |
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| dc.subject |
iron |
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| dc.subject |
genetic |
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| dc.subject |
single nucleotide polymorphism |
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| dc.subject |
gene-environment |
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| dc.title |
Polymorphisms in the Gene That Encodes the Iron Transport Protein Ferroportin 1 Influence Susceptibility to Tuberculosis |
en_US |
| dc.type |
Journal Article |
en_US |
| dc.description.version |
Accepted Manuscript |
en_US |
| dc.relation.journal |
Journal of Infectious Disease |
en_US |
| dash.depositing.author |
Sabeti, Pardis Christine
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| dc.date.available |
2012-11-13T19:02:52Z |
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FAS Scholarly Articles [5138]
Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University
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