Polymorphisms in the Gene That Encodes the Iron Transport Protein Ferroportin 1 Influence Susceptibility to Tuberculosis

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Polymorphisms in the Gene That Encodes the Iron Transport Protein Ferroportin 1 Influence Susceptibility to Tuberculosis

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dc.contributor.author Baker, Meghan Ann
dc.contributor.author Wilson, Douglas
dc.contributor.author Wallengren, Kristina
dc.contributor.author Sandgren, Andreas
dc.contributor.author Iartchouk, Oleg
dc.contributor.author Broodie, Nisha Monique
dc.contributor.author Goonesekera, Sunali D.
dc.contributor.author Sabeti, Pardis Christine
dc.contributor.author Murray, Megan Blanche
dc.date.accessioned 2012-11-13T19:02:52Z
dc.date.issued 2012
dc.identifier.citation Baker, Meghan Ann, Douglas Wilson, Kristina Wallengren, Andreas Sandgren, Oleg Iartchouk, Nisha Broodie, Sunali D. Goonesekra, Pardis C Sabeti, and Megan B. Murray. 2012. Polymorphisms in the gene that encodes the iron transport protein ferroportin 1 influence susceptibility to suberculosis. Journal of Infectious Disease 205(7): 1043-1047. en_US
dc.identifier.issn 0022-1899 en_US
dc.identifier.issn 1537-6613 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:9891821
dc.description.abstract Background: We studied the association between iron intake and polymorphisms in the iron transporter gene, SLC40A1, and the risk of tuberculosis. Methods: We compared iron intake, the frequency of SLC40A1 mutations, and interactions between these variables among 98 TB patients and 125 controls in Kwazulu-Natal, South Africa. Results: Four SLC40A1 SNPs were associated with an increased risk of tuberculosis and one with reduced risk. We also found a gene-environment interaction for four non-exonic SNPs and iron intake. Conclusions: This pilot study demonstrated an association between polymorphisms in SLC40A1 and tuberculosis and provided evidence for an interaction between dietary iron and SLC40A1. en_US
dc.description.sponsorship Organismic and Evolutionary Biology en_US
dc.language.iso en_US en_US
dc.publisher Oxford University Press en_US
dc.relation.isversionof doi:10.1093/infdis/jis026 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pubmed/22357659 en_US
dash.license OAP
dc.subject SLC40A1 en_US
dc.subject ferroportin en_US
dc.subject FPN1 en_US
dc.subject tuberculosis en_US
dc.subject mycobacterium en_US
dc.subject iron en_US
dc.subject genetic en_US
dc.subject single nucleotide polymorphism en_US
dc.subject gene-environment en_US
dc.title Polymorphisms in the Gene That Encodes the Iron Transport Protein Ferroportin 1 Influence Susceptibility to Tuberculosis en_US
dc.type Journal Article en_US
dc.description.version Accepted Manuscript en_US
dc.relation.journal Journal of Infectious Disease en_US
dash.depositing.author Sabeti, Pardis Christine
dc.date.available 2012-11-13T19:02:52Z

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  • FAS Scholarly Articles [6902]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University

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