Most Reported Genetic Associations with General Intelligence Are Probably False Positives

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Most Reported Genetic Associations with General Intelligence Are Probably False Positives

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dc.contributor.author Laibson, David I.
dc.contributor.author Chabris, Christopher F.
dc.contributor.author Hebert, Benjamin Michael
dc.contributor.author Benjamin, Daniel J.
dc.contributor.author Beauchamp, Jonathan P.
dc.contributor.author Cesarini, David
dc.contributor.author van der Loos, Matthijs J. H. M.
dc.contributor.author Johannesson, Magnus
dc.contributor.author Magnusson, Patrik K. E.
dc.contributor.author Lichtenstein, Paul
dc.contributor.author Atwood, Craig S.
dc.contributor.author Freese, Jeremy
dc.contributor.author Hauser, Taissa S.
dc.contributor.author Hauser, Robert M.
dc.contributor.author Christakis, Nicholas Alexander
dc.date.accessioned 2012-11-21T21:55:56Z
dc.date.issued 2012
dc.identifier.citation Chabris, Christopher F., Benjamin Michael Hebert, Daniel J. Benjamin, Jonathan P. Beauchamp, David Cesarini, Matthijs J. H. M. van der Loos, Magnus Johannesson, et al. 2012. Most reported genetic associations with general intelligence are probably false positives. Psychological Science 23(11): 1314-1323. en_US
dc.identifier.issn 0956-7976 en_US
dc.identifier.issn 1467-9280 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:9938142
dc.description.abstract General intelligence (g) and virtually all other behavioral traits are heritable. Associations between g and specific single-nucleotide polymorphisms (SNPs) in several candidate genes involved in brain function have been reported. We sought to replicate published associations between g and 12 specific genetic variants (in the genes DTNBP1, CTSD, DRD2, ANKK1, CHRM2, SSADH, COMT, BDNF, CHRNA4, DISC1, APOE, and SNAP25) using data sets from three independent, well-characterized longitudinal studies with samples of 5,571, 1,759, and 2,441 individuals. Of 32 independent tests across all three data sets, only 1 was nominally significant. By contrast, power analyses showed that we should have expected 10 to 15 significant associations, given reasonable assumptions for genotype effect sizes. For positive controls, we confirmed accepted genetic associations for Alzheimer’s disease and body mass index, and we used SNP-based calculations of genetic relatedness to replicate previous estimates that about half of the variance in g is accounted for by common genetic variation among individuals. We conclude that the molecular genetics of psychology and social science requires approaches that go beyond the examination of candidate genes. en_US
dc.description.sponsorship Economics en_US
dc.language.iso en_US en_US
dc.publisher Sage en_US
dc.relation.isversionof doi:10.1177/0956797611435528 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pubmed/23012269 en_US
dash.license OAP
dc.subject behavior genetics en_US
dc.subject cognitive ability en_US
dc.subject genetics en_US
dc.subject individual differences en_US
dc.subject intelligence en_US
dc.title Most Reported Genetic Associations with General Intelligence Are Probably False Positives en_US
dc.type Journal Article en_US
dc.description.version Author's Original en_US
dc.relation.journal Psychological Science en_US
dash.depositing.author Laibson, David I.
dc.date.available 2012-11-21T21:55:56Z

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  • FAS Scholarly Articles [7219]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University

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