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dc.contributor.authorLaibson, David I.
dc.contributor.authorChabris, Christopher F.
dc.contributor.authorHebert, Benjamin Michael
dc.contributor.authorBenjamin, Daniel J.
dc.contributor.authorBeauchamp, Jonathan P.
dc.contributor.authorCesarini, David
dc.contributor.authorvan der Loos, Matthijs J. H. M.
dc.contributor.authorJohannesson, Magnus
dc.contributor.authorMagnusson, Patrik K. E.
dc.contributor.authorLichtenstein, Paul
dc.contributor.authorAtwood, Craig S.
dc.contributor.authorFreese, Jeremy
dc.contributor.authorHauser, Taissa S.
dc.contributor.authorHauser, Robert M.
dc.contributor.authorChristakis, Nicholas Alexander
dc.date.accessioned2012-11-21T21:55:56Z
dc.date.issued2012
dc.identifier.citationChabris, Christopher F., Benjamin Michael Hebert, Daniel J. Benjamin, Jonathan P. Beauchamp, David Cesarini, Matthijs J. H. M. van der Loos, Magnus Johannesson, et al. 2012. Most reported genetic associations with general intelligence are probably false positives. Psychological Science 23(11): 1314-1323.en_US
dc.identifier.issn0956-7976en_US
dc.identifier.issn1467-9280en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:9938142
dc.description.abstractGeneral intelligence (g) and virtually all other behavioral traits are heritable. Associations between g and specific single-nucleotide polymorphisms (SNPs) in several candidate genes involved in brain function have been reported. We sought to replicate published associations between g and 12 specific genetic variants (in the genes DTNBP1, CTSD, DRD2, ANKK1, CHRM2, SSADH, COMT, BDNF, CHRNA4, DISC1, APOE, and SNAP25) using data sets from three independent, well-characterized longitudinal studies with samples of 5,571, 1,759, and 2,441 individuals. Of 32 independent tests across all three data sets, only 1 was nominally significant. By contrast, power analyses showed that we should have expected 10 to 15 significant associations, given reasonable assumptions for genotype effect sizes. For positive controls, we confirmed accepted genetic associations for Alzheimer’s disease and body mass index, and we used SNP-based calculations of genetic relatedness to replicate previous estimates that about half of the variance in g is accounted for by common genetic variation among individuals. We conclude that the molecular genetics of psychology and social science requires approaches that go beyond the examination of candidate genes.en_US
dc.description.sponsorshipEconomicsen_US
dc.language.isoen_USen_US
dc.publisherSageen_US
dc.relation.isversionofdoi:10.1177/0956797611435528en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pubmed/23012269en_US
dash.licenseOAP
dc.subjectbehavior geneticsen_US
dc.subjectcognitive abilityen_US
dc.subjectgeneticsen_US
dc.subjectindividual differencesen_US
dc.subjectintelligenceen_US
dc.titleMost Reported Genetic Associations with General Intelligence Are Probably False Positivesen_US
dc.typeJournal Articleen_US
dc.description.versionAuthor's Originalen_US
dc.relation.journalPsychological Scienceen_US
dash.depositing.authorLaibson, David I.
dc.date.available2012-11-21T21:55:56Z
dc.identifier.doi10.1177/0956797611435528*
dash.authorsorderedfalse
dash.contributor.affiliatedHebert, Benjamin
dash.contributor.affiliatedChristakis, Nicholas A.
dash.contributor.affiliatedLaibson, David
dc.identifier.orcid0000-0001-5547-1086


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