Epigenetic Effects of Polymorphic Y Chromosomes Modulate Chromatin Components, Immune Response, and Sexual Conflict

DSpace/Manakin Repository

Epigenetic Effects of Polymorphic Y Chromosomes Modulate Chromatin Components, Immune Response, and Sexual Conflict

Citable link to this page

. . . . . .

Title: Epigenetic Effects of Polymorphic Y Chromosomes Modulate Chromatin Components, Immune Response, and Sexual Conflict
Author: Silva, Bernardo Lemos; Hartl, Daniel L.; Branco, Alan T.

Note: Order does not necessarily reflect citation order of authors.

Citation: Silvia, Bernardo Lemos, Alan T. Branco, and Daniel L. Hartl. 2010. Epigenetic effects of polymorphic Y chromosomes modulate chromatin components, immune response, and sexual conflict. Proceedings of the National Academy of Sciences 107(36): 15826-15831.
Full Text & Related Files:
Abstract: Genetic conflicts between sexes and generations provide a foundation for understanding the functional evolution of sex chromosomes and sexually dimorphic phenotypes. Y chromosomes of Drosophila contain multi-megabase stretches of satellite DNA repeats and a handful of protein-coding genes that are monomorphic within species. Nevertheless, polymorphic variation in heterochromatic Y chromosomes of Drosophila result in genome-wide gene expression variation. Here we show that such naturally occurring Y-linked regulatory variation (YRV) can be detected in somatic tissues and contributes to the epigenetic balance of heterochromatin/euchromatin at three distinct loci showing position-effect variegation (PEV). Moreover, polymorphic Y chromosomes differentially affect the expression of thousands of genes in XXY female genotypes in which Y-linked protein-coding genes are not transcribed. The data show a disproportionate influence of YRV on the variable expression of genes whose protein products localize to the nucleus, have nucleic-acid binding activity, and are involved in transcription, chromosome organization, and chromatin assembly. These include key components such as HP1, Trithorax-like (GAGA factor), Su(var)3–9, Brahma, MCM2, ORC2, and inner centromere protein. Furthermore, mitochondria-related genes, immune response genes, and transposable elements are also disproportionally affected by Y chromosome polymorphism. These functional clusterings may arise as a consequence of the involvement of Y-linked heterochromatin in the origin and resolution of genetic conflicts between males and females. Taken together, our results indicate that Y chromosome heterochromatin serves as a major source of epigenetic variation in natural populations that interacts with chromatin components to modulate the expression of biologically relevant phenotypic variation.
Published Version: doi:10.1073/pnas.1010383107
Other Sources: http://www.ncbi.nlm.nih.gov/pubmed/20798037
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:9938754

Show full Dublin Core record

This item appears in the following Collection(s)

  • FAS Scholarly Articles [6902]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University
 
 

Search DASH


Advanced Search
 
 

Submitters