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dc.contributor.authorSilva, Bernardo Lemos
dc.contributor.authorHartl, Daniel L.
dc.contributor.authorBranco, Alan T.
dc.date.accessioned2012-11-26T16:55:23Z
dc.date.issued2010
dc.identifier.citationSilvia, Bernardo Lemos, Alan T. Branco, and Daniel L. Hartl. 2010. Epigenetic effects of polymorphic Y chromosomes modulate chromatin components, immune response, and sexual conflict. Proceedings of the National Academy of Sciences 107(36): 15826-15831.en_US
dc.identifier.issn1091-6490en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:9938754
dc.description.abstractGenetic conflicts between sexes and generations provide a foundation for understanding the functional evolution of sex chromosomes and sexually dimorphic phenotypes. Y chromosomes of Drosophila contain multi-megabase stretches of satellite DNA repeats and a handful of protein-coding genes that are monomorphic within species. Nevertheless, polymorphic variation in heterochromatic Y chromosomes of Drosophila result in genome-wide gene expression variation. Here we show that such naturally occurring Y-linked regulatory variation (YRV) can be detected in somatic tissues and contributes to the epigenetic balance of heterochromatin/euchromatin at three distinct loci showing position-effect variegation (PEV). Moreover, polymorphic Y chromosomes differentially affect the expression of thousands of genes in XXY female genotypes in which Y-linked protein-coding genes are not transcribed. The data show a disproportionate influence of YRV on the variable expression of genes whose protein products localize to the nucleus, have nucleic-acid binding activity, and are involved in transcription, chromosome organization, and chromatin assembly. These include key components such as HP1, Trithorax-like (GAGA factor), Su(var)3–9, Brahma, MCM2, ORC2, and inner centromere protein. Furthermore, mitochondria-related genes, immune response genes, and transposable elements are also disproportionally affected by Y chromosome polymorphism. These functional clusterings may arise as a consequence of the involvement of Y-linked heterochromatin in the origin and resolution of genetic conflicts between males and females. Taken together, our results indicate that Y chromosome heterochromatin serves as a major source of epigenetic variation in natural populations that interacts with chromatin components to modulate the expression of biologically relevant phenotypic variation.en_US
dc.description.sponsorshipOrganismic and Evolutionary Biologyen_US
dc.language.isoen_USen_US
dc.publisherNational Academy of Sciencesen_US
dc.relation.isversionofdoi:10.1073/pnas.1010383107en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pubmed/20798037en_US
dash.licenseLAA
dc.subjectevolutionen_US
dc.subjectheterochromatinen_US
dc.subjectposition-effect variegationen_US
dc.subjectregulatoryen_US
dc.subjectanimalsen_US
dc.subjectchromatinen_US
dc.subjectphysiologyen_US
dc.subjectdrosophilaen_US
dc.subjectgeneticsen_US
dc.subjectimmunologyen_US
dc.subjectepigeneticsen_US
dc.subjectgenetic polymorphismen_US
dc.subjectsexual behavioren_US
dc.subjectY chromosomeen_US
dc.titleEpigenetic Effects of Polymorphic Y Chromosomes Modulate Chromatin Components, Immune Response, and Sexual Conflicten_US
dc.typeJournal Articleen_US
dc.description.versionAuthor's Originalen_US
dc.relation.journalProceedings of the National Academy of Sciencesen_US
dash.depositing.authorHartl, Daniel L.
dash.waiver2010-07-15
dc.date.available2012-11-26T16:55:23Z
dc.identifier.doi10.1073/pnas.1010383107*
dash.authorsorderedfalse
dash.contributor.affiliatedHartl, Daniel
dash.contributor.affiliatedBranco, Alan
dash.contributor.affiliatedLemos, Bernardo


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