dc.contributor.author | Silva, Bernardo Lemos | |
dc.contributor.author | Hartl, Daniel L. | |
dc.contributor.author | Branco, Alan T. | |
dc.date.accessioned | 2012-11-26T16:55:23Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | Silvia, Bernardo Lemos, Alan T. Branco, and Daniel L. Hartl. 2010. Epigenetic effects of polymorphic Y chromosomes modulate chromatin components, immune response, and sexual conflict. Proceedings of the National Academy of Sciences 107(36): 15826-15831. | en_US |
dc.identifier.issn | 1091-6490 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:9938754 | |
dc.description.abstract | Genetic conflicts between sexes and generations provide a foundation for understanding the functional evolution of sex chromosomes and sexually dimorphic phenotypes. Y chromosomes of Drosophila contain multi-megabase stretches of satellite DNA repeats and a handful of protein-coding genes that are monomorphic within species. Nevertheless, polymorphic variation in heterochromatic Y chromosomes of Drosophila result in genome-wide gene expression variation. Here we show that such naturally occurring Y-linked regulatory variation (YRV) can be detected in somatic tissues and contributes to the epigenetic balance of heterochromatin/euchromatin at three distinct loci showing position-effect variegation (PEV). Moreover, polymorphic Y chromosomes differentially affect the expression of thousands of genes in XXY female genotypes in which Y-linked protein-coding genes are not transcribed. The data show a disproportionate influence of YRV on the variable expression of genes whose protein products localize to the nucleus, have nucleic-acid binding activity, and are involved in transcription, chromosome organization, and chromatin assembly. These include key components such as HP1, Trithorax-like (GAGA factor), Su(var)3–9, Brahma, MCM2, ORC2, and inner centromere protein. Furthermore, mitochondria-related genes, immune response genes, and transposable elements are also disproportionally affected by Y chromosome polymorphism. These functional clusterings may arise as a consequence of the involvement of Y-linked heterochromatin in the origin and resolution of genetic conflicts between males and females. Taken together, our results indicate that Y chromosome heterochromatin serves as a major source of epigenetic variation in natural populations that interacts with chromatin components to modulate the expression of biologically relevant phenotypic variation. | en_US |
dc.description.sponsorship | Organismic and Evolutionary Biology | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | National Academy of Sciences | en_US |
dc.relation.isversionof | doi:10.1073/pnas.1010383107 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pubmed/20798037 | en_US |
dash.license | LAA | |
dc.subject | evolution | en_US |
dc.subject | heterochromatin | en_US |
dc.subject | position-effect variegation | en_US |
dc.subject | regulatory | en_US |
dc.subject | animals | en_US |
dc.subject | chromatin | en_US |
dc.subject | physiology | en_US |
dc.subject | drosophila | en_US |
dc.subject | genetics | en_US |
dc.subject | immunology | en_US |
dc.subject | epigenetics | en_US |
dc.subject | genetic polymorphism | en_US |
dc.subject | sexual behavior | en_US |
dc.subject | Y chromosome | en_US |
dc.title | Epigenetic Effects of Polymorphic Y Chromosomes Modulate Chromatin Components, Immune Response, and Sexual Conflict | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Author's Original | en_US |
dc.relation.journal | Proceedings of the National Academy of Sciences | en_US |
dash.depositing.author | Hartl, Daniel L. | |
dash.waiver | 2010-07-15 | |
dc.date.available | 2012-11-26T16:55:23Z | |
dc.identifier.doi | 10.1073/pnas.1010383107 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Hartl, Daniel | |
dash.contributor.affiliated | Branco, Alan | |
dash.contributor.affiliated | Lemos, Bernardo | |