Functional Organization of a Neural Network for Aversive Olfactory Learning in Caenorhabditis elegans

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Functional Organization of a Neural Network for Aversive Olfactory Learning in Caenorhabditis elegans

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dc.contributor.author Ha, Heon-ick
dc.contributor.author Hendricks, Michael Shelton
dc.contributor.author Shen, Yu Serena
dc.contributor.author Gabel, Christopher V.
dc.contributor.author Fang-Yen, Christopher M.
dc.contributor.author Qin, Yuqi
dc.contributor.author Shen, Kang
dc.contributor.author Zhang, Yun
dc.contributor.author Samuel, Aravinthan D. T.
dc.contributor.author Colón-Ramos, Daniel
dc.date.accessioned 2012-11-30T16:57:18Z
dc.date.issued 2010
dc.identifier.citation Ha, Heon-ick, Michael Shelton Hendricks, Yu Serena Shen, Christopher V. Gabel, Christopher M. Fang-Yen, Yuqi Qin, Daniel Colón-Ramos, Kang Shen, Aravinthan D. T. Samuel, and Yun Zhang. 2010. Functional organization of a neural network for aversive olfactory learning in Caenorhabditis elegans. 68(6): 1173-1186. en_US
dc.identifier.issn 0896-6273 en_US
dc.identifier.issn 1097-4199 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:9969390
dc.description.abstract Many animals use their olfactory systems to learn to avoid dangers, but how neural circuits encode naive and learned olfactory preferences, and switch between those preferences, is poorly understood. Here, we map an olfactory network, from sensory input to motor output, which regulates the learned olfactory aversion of Caenorhabditis elegans for the smell of pathogenic bacteria. Naive animals prefer smells of pathogens but animals trained with pathogens lose this attraction. We find that two different neural circuits subserve these preferences, with one required for the naive preference and the other specifically for the learned preference. Calcium imaging and behavioral analysis reveal that the naive preference reflects the direct transduction of the activity of olfactory sensory neurons into motor response, whereas the learned preference involves modulations to signal transduction to downstream neurons to alter motor response. Thus, two different neural circuits regulate a behavioral switch between naive and learned olfactory preferences. en_US
dc.description.sponsorship Organismic and Evolutionary Biology en_US
dc.description.sponsorship Physics en_US
dc.language.iso en_US en_US
dc.publisher Elsevier en_US
dc.relation.isversionof doi:10.1016/j.neuron.2010.11.025 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pubmed/21172617 en_US
dash.license OAP
dc.title Functional Organization of a Neural Network for Aversive Olfactory Learning in Caenorhabditis elegans en_US
dc.type Journal Article en_US
dc.description.version Author's Original en_US
dc.relation.journal Neuron en_US
dash.depositing.author Samuel, Aravinthan D. T.
dc.date.available 2012-11-30T16:57:18Z

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  • FAS Scholarly Articles [7501]
    Peer reviewed scholarly articles from the Faculty of Arts and Sciences of Harvard University

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