%PDF-1.4
%
1 0 obj
<<
/Type /Catalog
/Version /1.4
/Pages 2 0 R
/PageLabels 3 0 R
/Metadata 4 0 R
/OpenAction 5 0 R
/Names 6 0 R
/Outlines 7 0 R
/OutputIntents [8 0 R 9 0 R]
>>
endobj
10 0 obj
<<
/Creator (Apache FOP Version 2.4)
/Producer (Apache FOP Version 2.4)
/CreationDate (D:20240328135400-04'00')
/Title (Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders)
/Keywords ()
/ModDate (D:20171220120809+01'00')
/Subject (Genome Medicine, 2017, doi:10.1186/s13073-017-0497-y)
/Author (HOANG NGUYEN)
>>
endobj
2 0 obj
<<
/Type /Pages
/Kids [11 0 R 12 0 R 13 0 R 14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R
21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R
31 0 R 32 0 R 33 0 R]
/Count 23
>>
endobj
3 0 obj
<<
/Nums [0 34 0 R]
>>
endobj
4 0 obj
<<
/Length 865
/Type /Metadata
/Subtype /XML
>>
stream
application/pdf
x-unknown
2024-03-28T13:54:00-04:00
Apache FOP Version 2.4
1.4
Apache FOP Version 2.4
2024-03-28T13:54:00-04:00
2024-03-28T13:54:00-04:00
endstream
endobj
5 0 obj
<<
/D [35 0 R /Fit]
/S /GoTo
>>
endobj
6 0 obj
<<
/Dests 36 0 R
>>
endobj
7 0 obj
<<
/Type /Outlines
/Count 65
/Last 37 0 R
/First 38 0 R
>>
endobj
8 0 obj
<<
/Type /OutputIntent
/OutputCondition (sRGB)
/DestOutputProfile 39 0 R
/S /GTS_PDFA1
/OutputConditionIdentifier (Custom)
/RegistryName ()
/Info (sRGB IEC61966-2.1)
>>
endobj
9 0 obj
<<
/Type /OutputIntent
/OutputCondition (sRGB)
/DestOutputProfile 39 0 R
/S /ISO_PDFE1
/OutputConditionIdentifier (Custom)
/RegistryName ()
/Info (sRGB IEC61966-2.1)
>>
endobj
11 0 obj
<<
/Resources 40 0 R
/Type /Page
/MediaBox [0.0 0.0 612.0 792.0]
/CropBox [0.0 0.0 612.0 792.0]
/BleedBox [0 0 612 792]
/TrimBox [0 0 612 792]
/Parent 2 0 R
/StructParents 0
/Tabs /S
/Annots [41 0 R 42 0 R 43 0 R 44 0 R 45 0 R]
/Contents 46 0 R
/Rotate 0
>>
endobj
12 0 obj
<<
/CropBox [0.0 0.0 595.0 791.0]
/Parent 2 0 R
/Type /Page
/Contents [47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R 53 0 R 54 0 R]
/Resources 55 0 R
/TrimBox [0 0 595 791]
/Thumb 56 0 R
/MediaBox [0.0 0.0 595.0 791.0]
/BleedBox [0 0 595 791]
/Annots [57 0 R 58 0 R 59 0 R 60 0 R 61 0 R 62 0 R]
/Rotate 0
>>
endobj
13 0 obj
<<
/CropBox [0.0 0.0 595.0 791.0]
/Parent 2 0 R
/Type /Page
/Contents 63 0 R
/Resources 64 0 R
/TrimBox [0 0 595 791]
/Thumb 65 0 R
/MediaBox [0.0 0.0 595.0 791.0]
/BleedBox [0 0 595 791]
/Annots [66 0 R 67 0 R 68 0 R 69 0 R 70 0 R 71 0 R 72 0 R 73 0 R 74 0 R 75 0 R
76 0 R 77 0 R 78 0 R 79 0 R 80 0 R 81 0 R 82 0 R 83 0 R 84 0 R 85 0 R
86 0 R 87 0 R 88 0 R 89 0 R 90 0 R 91 0 R 92 0 R 93 0 R 94 0 R 95 0 R
96 0 R 97 0 R 98 0 R 99 0 R 100 0 R 101 0 R 102 0 R 103 0 R 104 0 R 105 0 R
106 0 R 107 0 R 108 0 R]
/Rotate 0
>>
endobj
14 0 obj
<<
/CropBox [0.0 0.0 595.0 791.0]
/Parent 2 0 R
/Type /Page
/Contents 109 0 R
/Resources 110 0 R
/TrimBox [0 0 595 791]
/Thumb 111 0 R
/MediaBox [0.0 0.0 595.0 791.0]
/BleedBox [0 0 595 791]
/Annots [112 0 R 113 0 R 114 0 R 115 0 R 116 0 R 117 0 R 118 0 R 119 0 R 120 0 R 121 0 R
122 0 R 123 0 R 124 0 R 125 0 R 126 0 R 127 0 R 128 0 R 129 0 R 130 0 R 131 0 R
132 0 R 133 0 R 134 0 R 135 0 R 136 0 R 137 0 R 138 0 R 139 0 R 140 0 R 141 0 R
142 0 R 143 0 R 144 0 R 145 0 R 146 0 R 147 0 R 148 0 R 149 0 R 150 0 R 151 0 R
152 0 R 153 0 R]
/Rotate 0
>>
endobj
15 0 obj
<<
/CropBox [0.0 0.0 595.0 791.0]
/Parent 2 0 R
/Type /Page
/Contents 154 0 R
/Resources 155 0 R
/TrimBox [0 0 595 791]
/Thumb 156 0 R
/MediaBox [0.0 0.0 595.0 791.0]
/BleedBox [0 0 595 791]
/Annots [157 0 R 158 0 R 159 0 R 160 0 R 161 0 R 162 0 R 163 0 R 164 0 R 165 0 R 166 0 R
167 0 R 168 0 R 169 0 R]
/Rotate 0
>>
endobj
16 0 obj
<<
/CropBox [0.0 0.0 595.0 791.0]
/Parent 2 0 R
/Type /Page
/Contents 170 0 R
/Resources 171 0 R
/TrimBox [0 0 595 791]
/Thumb 172 0 R
/MediaBox [0.0 0.0 595.0 791.0]
/BleedBox [0 0 595 791]
/Annots [173 0 R 174 0 R 175 0 R 176 0 R 177 0 R 178 0 R 179 0 R 180 0 R]
/Rotate 0
>>
endobj
17 0 obj
<<
/CropBox [0.0 0.0 595.0 791.0]
/Parent 2 0 R
/Type /Page
/Contents 181 0 R
/Resources 182 0 R
/TrimBox [0 0 595 791]
/Thumb 183 0 R
/MediaBox [0.0 0.0 595.0 791.0]
/BleedBox [0 0 595 791]
/Annots [184 0 R 185 0 R 186 0 R 187 0 R 188 0 R 189 0 R 190 0 R 191 0 R 192 0 R 193 0 R
194 0 R 195 0 R 196 0 R 197 0 R 198 0 R 199 0 R 200 0 R 201 0 R 202 0 R 203 0 R
204 0 R 205 0 R 206 0 R 207 0 R 208 0 R 209 0 R]
/Rotate 0
>>
endobj
18 0 obj
<<
/CropBox [0.0 0.0 595.0 791.0]
/Parent 2 0 R
/Type /Page
/Contents 210 0 R
/Resources 211 0 R
/TrimBox [0 0 595 791]
/Thumb 212 0 R
/MediaBox [0.0 0.0 595.0 791.0]
/BleedBox [0 0 595 791]
/Annots [213 0 R 214 0 R 215 0 R 216 0 R 217 0 R 218 0 R 219 0 R 220 0 R 221 0 R 222 0 R
223 0 R 224 0 R 225 0 R 226 0 R]
/Rotate 0
>>
endobj
19 0 obj
<<
/CropBox [0.0 0.0 595.0 791.0]
/Parent 2 0 R
/Type /Page
/Contents 227 0 R
/Resources 228 0 R
/TrimBox [0 0 595 791]
/Thumb 229 0 R
/MediaBox [0.0 0.0 595.0 791.0]
/BleedBox [0 0 595 791]
/Annots [230 0 R 231 0 R 232 0 R 233 0 R 234 0 R]
/Rotate 0
>>
endobj
20 0 obj
<<
/CropBox [0.0 0.0 595.0 791.0]
/Parent 2 0 R
/Type /Page
/Contents 235 0 R
/Resources 236 0 R
/TrimBox [0 0 595 791]
/Thumb 237 0 R
/MediaBox [0.0 0.0 595.0 791.0]
/BleedBox [0 0 595 791]
/Annots [238 0 R 239 0 R 240 0 R 241 0 R 242 0 R 243 0 R 244 0 R 245 0 R 246 0 R 247 0 R
248 0 R 249 0 R 250 0 R 251 0 R 252 0 R 253 0 R 254 0 R]
/Rotate 0
>>
endobj
21 0 obj
<<
/CropBox [0.0 0.0 595.0 791.0]
/Parent 2 0 R
/Type /Page
/Contents 255 0 R
/Resources 256 0 R
/TrimBox [0 0 595 791]
/Thumb 257 0 R
/MediaBox [0.0 0.0 595.0 791.0]
/BleedBox [0 0 595 791]
/Annots [258 0 R 259 0 R 260 0 R 261 0 R 262 0 R 263 0 R]
/Rotate 0
>>
endobj
22 0 obj
<<
/CropBox [0.0 0.0 595.0 791.0]
/Parent 2 0 R
/Type /Page
/Contents 264 0 R
/Resources 265 0 R
/TrimBox [0 0 595 791]
/Thumb 266 0 R
/MediaBox [0.0 0.0 595.0 791.0]
/BleedBox [0 0 595 791]
/Annots [267 0 R 268 0 R 269 0 R 270 0 R 271 0 R 272 0 R 273 0 R 274 0 R 275 0 R 276 0 R
277 0 R 278 0 R 279 0 R 280 0 R 281 0 R 282 0 R 283 0 R 284 0 R 285 0 R 286 0 R
287 0 R 288 0 R 289 0 R]
/Rotate 0
>>
endobj
23 0 obj
<<
/CropBox [0.0 0.0 595.0 791.0]
/Parent 2 0 R
/Type /Page
/Contents 290 0 R
/Resources 291 0 R
/TrimBox [0 0 595 791]
/Thumb 292 0 R
/MediaBox [0.0 0.0 595.0 791.0]
/BleedBox [0 0 595 791]
/Annots [293 0 R 294 0 R 295 0 R 296 0 R 297 0 R 298 0 R 299 0 R 300 0 R]
/Rotate 0
>>
endobj
24 0 obj
<<
/CropBox [0.0 0.0 595.0 791.0]
/Parent 2 0 R
/Type /Page
/Contents 301 0 R
/Resources 302 0 R
/TrimBox [0 0 595 791]
/Thumb 303 0 R
/MediaBox [0.0 0.0 595.0 791.0]
/BleedBox [0 0 595 791]
/Annots [304 0 R 305 0 R 306 0 R 307 0 R 308 0 R 309 0 R 310 0 R 311 0 R 312 0 R]
/Rotate 0
>>
endobj
25 0 obj
<<
/CropBox [0.0 0.0 595.0 791.0]
/Parent 2 0 R
/Type /Page
/Contents 313 0 R
/Resources 314 0 R
/TrimBox [0 0 595 791]
/Thumb 315 0 R
/MediaBox [0.0 0.0 595.0 791.0]
/BleedBox [0 0 595 791]
/Annots [316 0 R 317 0 R]
/Rotate 0
>>
endobj
26 0 obj
<<
/CropBox [0.0 0.0 595.0 791.0]
/Parent 2 0 R
/Type /Page
/Contents 318 0 R
/Resources 319 0 R
/TrimBox [0 0 595 791]
/Thumb 320 0 R
/MediaBox [0.0 0.0 595.0 791.0]
/BleedBox [0 0 595 791]
/Annots [321 0 R 322 0 R 323 0 R 324 0 R 325 0 R 326 0 R]
/Rotate 0
>>
endobj
27 0 obj
<<
/CropBox [0.0 0.0 595.0 791.0]
/Parent 2 0 R
/Type /Page
/Contents 327 0 R
/Resources 328 0 R
/TrimBox [0 0 595 791]
/Thumb 329 0 R
/MediaBox [0.0 0.0 595.0 791.0]
/BleedBox [0 0 595 791]
/Annots [330 0 R 331 0 R 332 0 R]
/Rotate 0
>>
endobj
28 0 obj
<<
/CropBox [0.0 0.0 595.0 791.0]
/Parent 2 0 R
/Type /Page
/Contents 333 0 R
/Resources 334 0 R
/TrimBox [0 0 595 791]
/Thumb 335 0 R
/MediaBox [0.0 0.0 595.0 791.0]
/BleedBox [0 0 595 791]
/Annots [336 0 R 337 0 R 338 0 R 339 0 R 340 0 R 341 0 R 342 0 R 343 0 R 344 0 R 345 0 R
346 0 R 347 0 R 348 0 R 349 0 R 350 0 R 351 0 R 352 0 R 353 0 R 354 0 R 355 0 R
356 0 R 357 0 R 358 0 R 359 0 R 360 0 R 361 0 R 362 0 R 363 0 R 364 0 R 365 0 R
366 0 R]
/Rotate 0
>>
endobj
29 0 obj
<<
/CropBox [0.0 0.0 595.0 791.0]
/Parent 2 0 R
/Type /Page
/Contents 367 0 R
/Resources 368 0 R
/TrimBox [0 0 595 791]
/Thumb 369 0 R
/MediaBox [0.0 0.0 595.0 791.0]
/BleedBox [0 0 595 791]
/Annots [370 0 R 371 0 R 372 0 R 373 0 R 374 0 R 375 0 R 376 0 R 377 0 R 378 0 R 379 0 R
380 0 R 381 0 R 382 0 R 383 0 R 384 0 R 385 0 R 386 0 R 387 0 R 388 0 R 389 0 R
390 0 R 391 0 R 392 0 R 393 0 R 394 0 R 395 0 R 396 0 R 397 0 R 398 0 R 399 0 R
400 0 R 401 0 R 402 0 R 403 0 R 404 0 R 405 0 R 406 0 R]
/Rotate 0
>>
endobj
30 0 obj
<<
/CropBox [0.0 0.0 595.0 791.0]
/Parent 2 0 R
/Type /Page
/Contents 407 0 R
/Resources 408 0 R
/TrimBox [0 0 595 791]
/Thumb 409 0 R
/MediaBox [0.0 0.0 595.0 791.0]
/BleedBox [0 0 595 791]
/Annots [410 0 R 411 0 R 412 0 R 413 0 R 414 0 R 415 0 R 416 0 R 417 0 R 418 0 R 419 0 R
420 0 R 421 0 R 422 0 R 423 0 R]
/Rotate 0
>>
endobj
31 0 obj
<<
/CropBox [0.0 0.0 595.0 791.0]
/Parent 2 0 R
/Type /Page
/Contents 424 0 R
/Resources 425 0 R
/TrimBox [0 0 595 791]
/Thumb 426 0 R
/MediaBox [0.0 0.0 595.0 791.0]
/BleedBox [0 0 595 791]
/Annots [427 0 R 428 0 R 429 0 R 430 0 R 431 0 R]
/Rotate 0
>>
endobj
32 0 obj
<<
/CropBox [0.0 0.0 595.0 791.0]
/Parent 2 0 R
/Type /Page
/Contents 432 0 R
/Resources 433 0 R
/TrimBox [0 0 595 791]
/Thumb 434 0 R
/MediaBox [0.0 0.0 595.0 791.0]
/BleedBox [0 0 595 791]
/Annots [435 0 R 436 0 R 437 0 R 438 0 R 439 0 R 440 0 R 441 0 R 442 0 R 443 0 R 444 0 R
445 0 R 446 0 R]
/Rotate 0
>>
endobj
33 0 obj
<<
/CropBox [0.0 0.0 595.0 791.0]
/Parent 2 0 R
/Type /Page
/Contents 447 0 R
/Resources 448 0 R
/TrimBox [0 0 595 791]
/Thumb 449 0 R
/MediaBox [0.0 0.0 595.0 791.0]
/BleedBox [0 0 595 791]
/Rotate 0
>>
endobj
34 0 obj
<<
/S /D
>>
endobj
35 0 obj
<<
/CropBox [0 0 595 791]
/Parent 450 0 R
/Type /Page
/Contents [451 0 R 452 0 R 453 0 R 454 0 R 455 0 R 456 0 R 457 0 R 458 0 R]
/Resources <<
/ExtGState <<
/GS14 459 0 R
/GS4 460 0 R
/GS3 461 0 R
/GS10 462 0 R
/GS6 463 0 R
/GS5 464 0 R
>>
/XObject <<
/Im1 465 0 R
/Im0 466 0 R
>>
/ProcSet [/PDF /Text /ImageC /ImageI /ImageB]
/ColorSpace <<
/CS1 [/ICCBased 467 0 R]
>>
/Font <<
/F1 468 0 R
/T1_3 469 0 R
/T1_1 470 0 R
/T1_4 471 0 R
/T1_5 472 0 R
/T1_6 473 0 R
/T1_0 474 0 R
>>
/Properties <<
/MC1 475 0 R
/MC2 476 0 R
/MC3 477 0 R
/MC0 478 0 R
>>
>>
/TrimBox [0 0 595 791]
/Thumb 479 0 R
/MediaBox [0 0 595 791]
/BleedBox [0 0 595 791]
/Annots [480 0 R 481 0 R 482 0 R 483 0 R 484 0 R 485 0 R]
/Rotate 0
>>
endobj
36 0 obj
<<
/Kids [486 0 R 487 0 R 488 0 R 489 0 R 490 0 R]
>>
endobj
37 0 obj
<<
/C [0 0 0]
/Parent 7 0 R
/F 0
/Title (References)
/Dest (section*.65)
/Prev 491 0 R
/Count 0
>>
endobj
38 0 obj
<<
/Next 492 0 R
/C [0 0 0]
/Parent 7 0 R
/F 0
/Title (Abstract)
/Dest (section*.1)
/Count 5
/Last 493 0 R
/First 494 0 R
>>
endobj
39 0 obj
<<
/Length 2574
/N 3
/Filter /FlateDecode
/Range [0 1 0 1 0 1]
>>
stream
HyTSwoɞc
[5laQIBHADED2mtFOE.c}088GNg9w߽ '0 ֠Jb
2y.-;!KZ ^i"L0-
@8(r;q7Ly&Qq4j|9
V)gB0iW8#8wթ8_٥ʨQQj@&A)/g>'K t;\
ӥ$պFZUn(4T%)뫔0C&Zi8bxEB;Pӓ̹Aom?W=
x- [ 0}y)7ta>jT7@tܛ`q2ʀ&6ZLĄ?_yxg)˔zçLU*uSkSeO4?c. R
߁-25 S>ӣVd`rn~Y&+`;A4 A9 =-tl`;~p Gp| [`L`< "AYA+Cb(R, *T2B-
ꇆnQt}MA0alSx k&^>0|>_',G!"F$H:R!zFQd?r9\A&GrQhE]a4zBgE#H *B=0HIpp0MxJ$D1D, VĭKĻYdE"EI2EBGt4MzNr!YK ?%_(0J:EAiQ(()ӔWT6U@P+!~mDeԴ!hӦh/']B/ҏӿ?a0nhF!X8܌kc&5S6lIa2cKMA!E#ƒdV(kel
}}Cq9
N')].uJr
wG xR^[oƜchg`>b$*~ :Eb~,m,-ݖ,Y¬*6X[ݱF=3뭷Y~dó tizf6~`{v.Ng#{}}jc1X6fm;'_9 r:8q:˜O:ϸ8uJqnv=MmR 4
n3ܣkGݯz=[==<=GTB(/S,]6*-W:#7*e^YDY}UjAyT`#D="b{ų+ʯ:!kJ4Gmt}uC%K7YVfFY.=b?SƕƩȺy
چk5%4m7lqlioZlG+Zzmzy]?uuw|"űNwW&e֥ﺱ*|j5kyݭǯg^ykEklD_p߶7Dmo꿻1ml{Mś
nLl<9O [$h՛BdҞ@iءG&vVǥ8nRĩ7u\ЭD- u`ֲK³8%yhYѹJº;.!
zpg_XQKFAǿ=ȼ:ɹ8ʷ6˶5̵5͵6ζ7ϸ9к<Ѿ?DINU\dlvۀ܊ݖޢ)߯6DScs
2F[p(@Xr4Pm8Ww)Km
endstream
endobj
40 0 obj
<<
/Font 495 0 R
/ProcSet [/PDF /ImageB /ImageC /Text]
/XObject <<
/Im1 496 0 R
/Im2 497 0 R
>>
/ColorSpace 498 0 R
>>
endobj
41 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [50.0 406.968 338.432 418.968]
/C [0 0 0]
/Border [0 0 0]
/A 499 0 R
/H /I
/StructParent 1
>>
endobj
42 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [489.344 346.368 522.32 358.368]
/C [0 0 0]
/Border [0 0 0]
/A 500 0 R
/H /I
/StructParent 2
>>
endobj
43 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [50.0 331.968 427.448 343.968]
/C [0 0 0]
/Border [0 0 0]
/A 500 0 R
/H /I
/StructParent 3
>>
endobj
44 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [278.48 251.768 361.172 263.768]
/C [0 0 0]
/Border [0 0 0]
/A 501 0 R
/H /I
/StructParent 4
>>
endobj
45 0 obj
<<
/Type /Annot
/Subtype /Link
/Rect [50.0 217.368 115.424 229.368]
/C [0 0 0]
/Border [0 0 0]
/A 502 0 R
/H /I
/StructParent 5
>>
endobj
46 0 obj
<<
/Length 2447
/Filter /FlateDecode
>>
stream
x\Ko6б9T&OAy)&FZE?Q]vĈc3ș~9N@o_1ٙ͌C7?Co^vٳ/T *y!qeo>Sûë/= CtOj|swZQwx?|z88O#z+l31[㐍ӄI\4)NcC4$d߹84ӘHk.{lUic9+zO6q'L