Browsing by Author "Ricq, Emily"

Now showing items 1-4 of 4

    • Brain-Penetrant LSD1 Inhibitors Can Block Memory Consolidation 

      Neelamegam, Ramesh; Ricq, Emily Louise; Malvaez, Melissa; Patnaik, Debasis; Norton, Stephanie; Carlin, Stephen M.; Hill, Ian Thomas; Wood, Marcelo A.; Haggarty, Stephen John; Hooker, Jacob M (American Chemical Society (ACS), 2012)
      Modulation of histone modifications in the brain may represent a new mechanism for brain disorder therapy. Post-translational modifications of histones regulate gene expression, affecting major cellular processes such as ...

    • Chemical Neurobiology of the Histone Lysine Demethylase KDM1A 

      Ricq, Emily (2016-05-18)
      Epigenetic mechanisms regulate gene expression and mediate interactions between genetic factors and environmental exposures. The enzymes responsible for epigenetic regulation may thus be important therapeutic targets for ...

    • A Philosophy for CNS Radiotracer Design 

      Van de Bittner, Genevieve C.; Ricq, Emily L.; Hooker, Jacob M. (American Chemical Society, 2014)
      Conspectus Decades after its discovery, positron emission tomography (PET) remains the premier tool for imaging neurochemistry in living humans. Technological improvements in radiolabeling methods, camera design, and image ...

    • Plasticity of Ether Lipids Promotes Ferroptosis Susceptibility and Evasion 

      Zou, Yilong; Henry, Whitney S.; Ricq, Emily; Graham, Emily; Phadnis, Vaishnavi; Maretich, Pema; Paradkar, Sateja; Boehnke, Natalie; Deik, Amy; Reinhardt, Ferenc; Eaton, John K.; Ferguson, Bryan; Wang, Wenyu; Fairman, Joshua; Keys, Heather R.; Dančík, Vlado; Clish, Clary B.; Clemons, Paul; Hammond, Paula; Boyer, Laurie A.; Weinberg, Robert; Schreiber, Stuart L. (Springer Science and Business Media LLC, 2020-09-16)
      Ferroptosis, an iron-dependent, non-apoptotic cell death program, is involved in various degenerative diseases and represents a targetable vulnerability in certain cancers1. The ferroptosis-susceptible cell state can either ...