Browsing by Author "Kirsch, Irving"
Now showing items 1-13 of 13
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Are All Placebo Effects Equal? Placebo Pills, Sham Acupuncture, Cue Conditioning and Their Association
Kong, Jian; Spaeth, Rosa; Cook, Amanda; Kirsch, Irving; Claggett, Brian; Vangel, Mark; Gollub, Randy L.; Smoller, Jordan W.; Kaptchuk, Ted J. (Public Library of Science, 2013)Placebo treatments and healing rituals have been used to treat pain throughout history. The present within-subject crossover study examines the variability in individual responses to placebo treatment with verbal suggestion ... -
Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in Irritable Bowel Syndrome
Hall, Kathryn Tayo; Lembo, Anthony J.; Kirsch, Irving; Ziogas, Dimitrios C.; Douaiher, Jeffrey; Jensen, Karin; Conboy, Lisa Ann; Kelley, John Michael; Kokkotou, Efi G.; Kaptchuk, Ted Jack (Public Library of Science, 2012)Identifying patients who are potential placebo responders has major implications for clinical practice and trial design. Catechol-O-methyltransferase (COMT), an important enzyme in dopamine catabolism plays a key role in ... -
Conscientiousness is modified by genetic variation in catechol-O-methyltransferase to reduce symptom complaints in IBS patients
Hall, Kathryn T; Tolkin, Benjamin R; Chinn, Garrett M; Kirsch, Irving; Kelley, John M; Lembo, Anthony J; Kaptchuk, Ted J; Kokkotou, Efi; Davis, Roger B; Conboy, Lisa A (BlackWell Publishing Ltd, 2014)Background: Attention to and perception of physical sensations and somatic states can significantly influence reporting of complaints and symptoms in the context of clinical care and randomized trials. Although anxiety and ... -
Default mode network connectivity encodes clinical pain: An arterial spin labeling study
Loggia, Marco Luciano; Kim, Jieun; Gollub, Randy Lyanne; Vangel, Mark G.; Kirsch, Irving; Kong, Jian; Wasan, Ajay D.; Napadow, Vitaly J. (Ovid Technologies (Wolters Kluwer Health), 2013)Neuroimaging studies have suggested the presence of alterations in the anatomo-functional properties of the brain of patients with chronic pain. However, investigation of the brain circuitry supporting the perception of ... -
Effectiveness of Non-Benzodiazepine Hypnotics in Treatment of Adult Insomnia: Meta-Analysis of Data Submitted to the Food and Drug Administration
Huedo-Medina, Tania B; Kirsch, Irving; Middlemass, Jo; Klonizakis, Markos; Siriwardena, A Niroshan (BMJ Publishing Group Ltd., 2012)Objectives: To investigate the effectiveness of non-benzodiazepine hypnotics (Z drugs) and associated placebo responses in adults and to evaluate potential moderators of effectiveness in a dataset used to approve these ... -
The Efficacy of Paroxetine and Placebo in Treating Anxiety and Depression: A Meta-Analysis of Change on the Hamilton Rating Scales
Sugarman, Michael A.; Loree, Amy M.; Baltes, Boris B.; Grekin, Emily R.; Kirsch, Irving (Public Library of Science, 2014)Background: Previous meta-analyses of published and unpublished trials indicate that antidepressants provide modest benefits compared to placebo in the treatment of depression; some have argued that these benefits are not ... -
A Neural Mechanism for Nonconscious Activation of Conditioned Placebo and Nocebo Responses
Jensen, Karin B.; Kaptchuk, Ted J.; Chen, Xiaoyan; Kirsch, Irving; Ingvar, Martin; Gollub, Randy L.; Kong, Jian (Oxford University Press, 2014)Fundamental aspects of human behavior operate outside of conscious awareness. Yet, theories of conditioned responses in humans, such as placebo and nocebo effects on pain, have a strong emphasis on conscious recognition ... -
Not seeing or feeling is still believing: conscious and non-conscious pain modulation after direct and observational learning
Egorova, Natalia; Park, Joel; Orr, Scott P.; Kirsch, Irving; Gollub, Randy L.; Kong, Jian (Nature Publishing Group, 2015)Our experience with the world is shaped not only directly through personal exposure but also indirectly through observing others and learning from their experiences. Using a conditioning paradigm, we investigated how ... -
Open-label placebo treatment in chronic low back pain: a randomized controlled trial
Carvalho, Cláudia; Caetano, Joaquim Machado; Cunha, Lidia; Rebouta, Paula; Kaptchuk, Ted J.; Kirsch, Irving (Wolters Kluwer, 2016)Abstract This randomized controlled trial was performed to investigate whether placebo effects in chronic low back pain could be harnessed ethically by adding open-label placebo (OLP) treatment to treatment as usual (TAU) ... -
Patient and Practitioner Influences on the Placebo Effect in Irritable Bowel Syndrome
Kelley, John Michael; Lembo, Anthony J.; Ablon, John Stuart; Villanueva, Joel J.; Conboy, Lisa Ann; Levy, Raymond Arthur; Marci, Carl David; Kerr, Catherine; Kirsch, Irving; Jacobson, Eric Emil; Riess, Helen; Kaptchuk, Ted Jack (Ovid Technologies (Wolters Kluwer Health), 2009)Objective: To determine whether placebo responses can be explained by characteristics of the patient, the practitioner, or their interpersonal interaction. Methods: We performed an analysis of videotape and psychometric ... -
Placebo Responses in Genetically Determined Intellectual Disability: A Meta-Analysis
Curie, Aurore; Yang, Kathy; Kirsch, Irving; Gollub, Randy L.; des Portes, Vincent; Kaptchuk, Ted J.; Jensen, Karin B. (Public Library of Science, 2015)Background: Genetically determined Intellectual Disability (ID) is an intractable condition that involves severe impairment of mental abilities such as learning, reasoning and predicting the future. As of today, little is ... -
A Systematic Review of Comparative Efficacy of Treatments and Controls for Depression
Khan, Arif; Faucett, James; Lichtenberg, Pesach; Kirsch, Irving; Brown, Walter A. (Public Library of Science, 2012)Background: Although previous meta-analyses have examined effects of antidepressants, psychotherapy, and alternative therapies for depression, the efficacy of these treatments alone and in combination has not been ... -
Well-Loved Music Robustly Relieves Pain: A Randomized, Controlled Trial
Hsieh, Christine; Kong, Jian; Kirsch, Irving; Edwards, Robert R.; Jensen, Karin B.; Kaptchuk, Ted J.; Gollub, Randy L. (Public Library of Science, 2014)Music has pain-relieving effects, but its mechanisms remain unclear. We sought to verify previously studied analgesic components and further elucidate the underpinnings of music analgesia. Using a well-characterized ...