Now showing items 1-4 of 4

    • CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation 

      Hayakawa, Kazuhide; Pham, Loc-Duyen; Seo, Ji-Hae; Miyamoto, Nobukazu; Maki, Takakuni; Sakadzic, Sava; Boas, David A.; van Leyen, Klaus J.; Waeber, Christian; Kim, Kyu-Won; Arai, Ken; Lo, Eng H. (SAGE Publications, 2016)
      There are numerous barriers to white matter repair after CNS injury and the underlying mechanisms remain to be fully understood. In this study, we propose the hypothesis that inflammatory macrophages in damaged white matter ...
    • Mechanisms of oligodendrocyte regeneration from ventricular-subventricular zone-derived progenitor cells in white matter diseases 

      Maki, Takakuni; Liang, Anna C.; Miyamoto, Nobukazu; Lo, Eng H.; Arai, Ken (Frontiers Media S.A., 2013)
      White matter dysfunction is an important part of many CNS disorders including multiple sclerosis (MS) and vascular dementia. Within injured areas, myelin loss and oligodendrocyte death may trigger endogenous attempts at ...
    • Oligodendrocyte Precursor Cells Support Blood-Brain Barrier Integrity via TGF-β Signaling 

      Seo, Ji Hae; Maki, Takakuni; Maeda, Mitsuyo; Miyamoto, Nobukazu; Liang, Anna C.; Hayakawa, Kazuhide; Pham, Loc-Duyen D.; Suwa, Fumihiko; Taguchi, Akihiko; Matsuyama, Tomohiro; Ihara, Masafumi; Kim, Kyu-Won; Lo, Eng H.; Arai, Ken (Public Library of Science, 2014)
      Trophic coupling between cerebral endothelium and their neighboring cells is required for the development and maintenance of blood-brain barrier (BBB) function. Here we report that oligodendrocyte precursor cells (OPCs) ...
    • Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β-amyloid 

      Maki, Takakuni; Okamoto, Yoko; Carare, Roxana O; Hase, Yoshiki; Hattori, Yorito; Hawkes, Cheryl A; Saito, Satoshi; Yamamoto, Yumi; Terasaki, Yasukazu; Ishibashi-Ueda, Hatsue; Taguchi, Akihiko; Takahashi, Ryosuke; Miyakawa, Taihei; Kalaria, Raj N; Lo, Eng H; Arai, Ken; Ihara, Masafumi (Blackwell Publishing Ltd, 2014)
      Objective: Brain amyloidosis is a key feature of Alzheimer's disease (AD). It also incorporates cerebrovascular amyloid β (Aβ) in the form of cerebral amyloid angiopathy (CAA) involving neurovascular dysfunction. We have ...