Now showing items 1-3 of 3

    • G3BP–Caprin1–USP10 complexes mediate stress granule condensation and associate with 40S subunits 

      Kedersha, Nancy; Panas, Marc D.; Achorn, Christopher A.; Lyons, Shawn; Tisdale, Sarah; Hickman, Tyler; Thomas, Marshall; Lieberman, Judy; McInerney, Gerald M.; Ivanov, Pavel; Anderson, Paul (The Rockefeller University Press, 2016)
      Mammalian stress granules (SGs) contain stalled translation preinitiation complexes that are assembled into discrete granules by specific RNA-binding proteins such as G3BP. We now show that cells lacking both G3BP1 and ...
    • Vinca alkaloid drugs promote stress-induced translational repression and stress granule formation 

      Szaflarski, Witold; Fay, Marta M.; Kedersha, Nancy; Zabel, Maciej; Anderson, Paul; Ivanov, Pavel (Impact Journals LLC, 2016)
      Resistance to chemotherapy drugs is a serious therapeutic problem and its underlying molecular mechanisms are complex. Stress granules (SGs), cytoplasmic ribonucleoprotein complexes assembled in cells exposed to stress, ...
    • YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression 

      Lyons, Shawn M.; Achorn, Chris; Kedersha, Nancy L.; Anderson, Paul J.; Ivanov, Pavel (Oxford University Press, 2016)
      Stress-induced angiogenin (ANG)-mediated tRNA cleavage promotes a cascade of cellular events that starts with production of tRNA-derived stress-induced RNAs (tiRNAs) and culminates with enhanced cell survival. This stress ...