Now showing items 1-5 of 5

    • Fixation in finite populations evolving in fluctuating environments 

      Ashcroft, Peter; Altrock, Philipp M.; Galla, Tobias (The Royal Society, 2014)
      The environment in which a population evolves can have a crucial impact on selection. We study evolutionary dynamics in finite populations of fixed size in a changing environment. The population dynamics are driven by birth ...
    • Mathematical Modeling of Erythrocyte Chimerism Informs Genetic Intervention Strategies for Sickle Cell Disease 

      Brendel, Christian; Renella, Raffaele; Michor, Franziska; Altrock, Philipp; Orkin, Stuart; Williams, David (Wiley, 2016-07-14)
      Recent advances in gene therapy and genome-engineering technologies offer the opportunity to correct sickle cell disease (SCD), a heritable disorder caused by a point mutation in the beta-globin gene. The developmental ...
    • Non-cell autonomous tumor-growth driving supports sub-clonal heterogeneity 

      Marusyk, Andriy; Tabassum, Doris P.; Altrock, Philipp M.; Almendro, Vanessa; Michor, Franziska; Polyak, Kornelia (2014)
      SUMMARY Cancers arise through a process of somatic evolution that can result in substantial sub-clonal heterogeneity within tumors. The mechanisms responsible for the coexistence of distinct sub-clones and the biological ...
    • Universality of weak selection 

      Bin Wu; Altrock, Philipp Martin; Wang, Long; Traulsen, Arne (American Physical Society (APS), 2010)
      Weak selection, which means a phenotype is slightly advantageous over another, is an important limiting case in evolutionary biology. Recently, it has been introduced into evolutionary game theory. In evolutionary game ...
    • Which games are growing bacterial populations playing? 

      Li, Xiang-Yi; Pietschke, Cleo; Fraune, Sebastian; Altrock, Philipp M.; Bosch, Thomas C. G.; Traulsen, Arne (The Royal Society, 2015)
      Microbial communities display complex population dynamics, both in frequency and absolute density. Evolutionary game theory provides a natural approach to analyse and model this complexity by studying the detailed interactions ...