Browsing by Author "Liang, Huan"
Now showing items 1-5 of 5
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A Highly Specific Probe for Sensing Hydrogen Sulfide in Live Cells Based on Copper-Initiated Fluorogen with Aggregation-Induced Emission Characteristics
Li, Xin; Yang, Chengyu; Wu, Kai; Hu, Yongzhou; Han, Yifeng; Liang, Steven H. (Ivyspring International Publisher, 2014)Here we reported the first fluorescent probe with aggregation-induced emission characteristics, namely AIE-S, for the detection of hydrogen sulfide (H2S) in live cells. The detection system is selective for complicated ... -
Imaging hydrogen peroxide in Alzheimer’s disease via cascade signal amplification
Yang, Jian; Yang, Jing; Liang, Steven H.; Xu, Yungen; Moore, Anna; Ran, Chongzhao (Nature Publishing Group, 2016)In brains of Alzheimer’s disease (AD), reactive oxygen species (ROS) levels are significantly higher than that of healthy brains. Evidence suggests that, during AD onset and progression, a vicious cycle revolves around ... -
PET Imaging of Fatty Acid Amide Hydrolase with [18F]DOPP in Nonhuman Primates
Rotstein, Benjamin H.; Wey, Hsiao-Ying; Shoup, Timothy M.; Wilson, Alan A.; Liang, Steven H.; Hooker, Jacob M.; Vasdev, Neil (American Chemical Society, 2014)Fatty acid amide hydrolase (FAAH) regulates endocannabinoid signaling. [11C]CURB, an irreversibly binding FAAH inhibitor, has been developed for clinical research imaging with PET. However, no fluorine-18 labeled radiotracer ... -
Practical Radiosynthesis and Preclinical Neuroimaging of [11C]isradipine, A Calcium Channel Antagonist
Rotstein, Benjamin H.; Liang, Steven H.; Belov, Vasily V.; Livni, Eli; Levine, Dylan B.; Bonab, Ali A.; Papisov, Mikhail I.; Perlis, Roy H.; Vasdev, Neil (2016)In the interest of developing in vivo positron emission tomography (PET) probes for neuroimaging of calcium channels, we have prepared a carbon-11 isotopologue of a dihydropyridine Ca2+-channel antagonist, isradipine. ... -
Synthesis and Preclinical Evaluation of Sulfonamido-based [11C-Carbonyl]-Carbamates and Ureas for Imaging Monoacylglycerol Lipase
Wang, Lu; Mori, Wakana; Cheng, Ran; Yui, Joji; Hatori, Akiko; Ma, Longle; Zhang, Yiding; Rotstein, Benjamin H.; Fujinaga, Masayuki; Shimoda, Yoko; Yamasaki, Tomoteru; Xie, Lin; Nagai, Yuji; Minamimoto, Takafumi; Higuchi, Makoto; Vasdev, Neil; Zhang, Ming-Rong; Liang, Steven H. (Ivyspring International Publisher, 2016)Monoacylglycerol lipase (MAGL) is a 33 kDa member of the serine hydrolase superfamily that preferentially degrades 2-arachidonoylglycerol (2-AG) to arachidonic acid in the endocannabinoid system. Inhibition of MAGL is not ...