Browsing by Author "Chauhan, Sunil"

Now showing items 1-20 of 43

    • Alloimmunity and Tolerance in Corneal Transplantation 

      Amouzegar, Afsaneh; Chauhan, Sunil Kumar; Dana, Reza (The American Association of Immunologists, 2016)
      Corneal transplantation is one of the most prevalent and successful forms of solid tissue transplantation. Despite favorable outcomes, immune-mediated graft rejection still remains the major cause of corneal allograft ...

    • Amelioration of Murine Dry Eye Disease by Topical Antagonist to Chemokine Receptor 2 

      Goyal, Sunali; Chauhan, Sunil Kumar; Zhang, Qiang; Dana, Reza (American Medical Association (AMA), 2009)
      Objective To determine the effect of a topical antagonist to the chemokine receptor 2 (CCR2) in a murine model of dry eye disease. Methods The effects of a topical CCR2 antagonist and a vehicle control treatment were ...

    • Anti-angiogenesis Effect of the Novel Anti-inflammatory and Pro-resolving Lipid Mediators 

      Jin, Yiping; Arita, Makoto; Zhang, Qiang; Saban, Daniel R.; Chauhan, Sunil Kumar; Chiang, Nan; Serhan, Charles Nicholas; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2009)
      Purpose.Resolvins and lipoxins are lipid mediators generated from essential polyunsaturated fatty acids that are the first dual anti-inflammatory and pro-resolving signals identified in the resolution phase of inflammation. ...

    • Autoimmunity in Dry Eye Is Due to Resistance of Th17 to Treg Suppression 

      Chauhan, Sunil Kumar; El Annan, Jaafar; Ecoiffier, Tatiana; Goyal, Sunali; Zhang, Q.; Saban, Daniel R.; Dana, Reza (The American Association of Immunologists, 2009)
      Dry eye disease (DED), an inflammatory autoimmune disorder affecting the ocular surface, degrades visual performance and the quality of life of more than 10 million people in the United States alone. The primary limitation ...

    • b-FGF Induces Corneal Blood and Lymphatic Vessel Growth in a Spatially Distinct Pattern 

      Hajrasouliha, Amir R.; Sadrai, Zahra; Chauhan, Sunil Kumar; Dana, Reza (Ovid Technologies (Wolters Kluwer Health), 2012)
      Purpose To study the spatial variances in ligand expression and angiogenic effect in response to the inflammatory response induced by b-FGF. Methods b-FGF micropellets (80ng) were implanted in the temporal side ...

    • Blockade of Prolymphangiogenic Vascular Endothelial Growth Factor C in Dry Eye Disease 

      Goyal, Sunali; Chauhan, Sunil Kumar; Dana, Reza (American Medical Association (AMA), 2012)
      Objective To determine if blocking prolymphangiogenic factors like VEGF-C would suppress alloimmunity in dry eye disease (DED) using a murine model. Methods The effects of intraperitoneal injections of 400 μg of ...

    • CCL-21 Conditioned Regulatory T Cells Induce Allotolerance through Enhanced Homing to Lymphoid Tissue 

      Chauhan, Sunil Kumar; Saban, Daniel R.; Dohlman, Thomas H.; Dana, Reza (The American Association of Immunologists, 2013)
      Regulatory T cells (Tregs) are instrumental in the induction and maintenance of tolerance, including in transplantation. Tregs induce allotolerance by interacting with antigen-presenting cells (APC) and T cells, interactions ...

    • The CCR6/CCL20 Axis Mediates Th17 Cell Migration to the Ocular Surface in Dry Eye Disease 

      Dohlman, Thomas H.; Chauhan, Sunil Kumar; Kodati, Shilpa; Hua, Jing; Chen, Yihe; Omoto, Masahiro; Sadrai, Zahra; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2013)
      Purpose. Th17 cells are believed to be the primary effector cells in the pathogenesis of dry eye disease (DED). However, the mechanisms by which Th17 cells migrate from the lymphoid tissues to the ocular surface are ...

    • CCR7 Is Critical for the Induction and Maintenance of Th17 Immunity in Dry Eye Disease 

      Kodati, Shilpa; Chauhan, Sunil Kumar; Chen, Yihe; Dohlman, Thomas H.; Karimian, Parisa; Saban, Daniel; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2014)
      Purpose. We characterized antigen-presenting cell (APC)–relevant chemokine receptor expression in dry eye disease (DED), and investigated the effect of topical CC chemokine receptor (CCR)-7 blockade specifically on Th17 ...

    • Change in Prostaglandin Expression Levels and Synthesizing Activities in Dry Eye Disease 

      Shim, Jongwoo; Park, Changhun; Lee, Hyun Soo; Park, Min Soo; Lim, Hyung Taek; Chauhan, Sunil Kumar; Dana, Reza; Lee, Hyon; Lee, Hyung Keun (Elsevier BV, 2012)
      Objective To investigate the expression level of prostaglandins (PGs) and their de novo synthesis in dry eye (DE) disease. Design Cross-sectional case-control study and in vivo mouse experimental study. Parti ...

    • Characterization of Effector T Cells in Dry Eye Disease 

      Annan, Jaafar; Chauhan, Sunil; Ecoiffier, Tatiana; Zhang, Qiang; Saban, Daniel; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2009)
      purpose. Dry eye disease (DED) is associated with ocular surface inflammation that is thought to be mediated primarily by CD4 T cells. The purpose of this study was to investigate whether this T cell–mediated immune response ...

    • Characterization of Langerin-Expressing Dendritic Cell Subsets in the Normal Cornea 

      Hattori, Takaaki; Chauhan, Sunil Kumar; Lee, Hyunsoo; Ueno, Hiroki; Dana, Reza; Kaplan, Daniel H.; Saban, Daniel R. (Association for Research in Vision and Ophthalmology (ARVO), 2011)
      Purpose. In addition to Langerhans cells (LCs), other dendritic cells (CD11c+) have recently been shown to express Langerin (c-type lectin). In skin, (non-LC) Langerin+ dendritic cells initiate adaptive immunity. However, ...

    • ‘Chimeric’ Grafts Assembled from Multiple Allodisparate Donors Enjoy Enhanced Transplant Survival 

      Saban, Daniel R.; Chauhan, Sunil Kumar; Zhang, Xian; El-Annan, Jaafar; Jin, Y.; Dana, Reza (Wiley-Blackwell, 2009)
      Certain components of a graft that provoke alloimmunity may not be vital for graft function or critical as targets of rejection. Corneal transplantation is an example of this since graft epithelium plays a role in ...

    • Chronic Dry Eye Disease is Principally Mediated by Effector Memory Th17 Cells 

      Chen, Yihe; Chauhan, Sunil K.; Lee, Hyun Soo; Saban, Daniel R.; Dana, Reza (2013)
      Recent experimental and clinical data suggest that there is a link between dry eye disease (DED) and T cell-mediated immunity. However, whether these immune responses are a consequence or cause of ocular surface inflammation ...

    • Corneal Lymphatics: Role in Ocular Inflammation as Inducer and Responder of Adaptive Immunity 

      Chauhan, Sunil K.; Dohlman, Thomas H.; Dana, Reza (2014)
      The normal cornea is devoid of lymphatic and blood vessels, thus suppressing both the afferent (lymphatic) and efferent (vascular) arms of the immune response–contributing to its ‘immune privilege’. Inflammation, however, ...

    • Dependence of Corneal Stem/Progenitor Cells on Ocular Surface Innervation 

      Ueno, Hiroki; Ferrari, Giulio; Hattori, Takaaki; Saban, Daniel R.; Katikireddy, Kishore R.; Chauhan, Sunil Kumar; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2012)
      Purpose. Neurotrophic keratopathy (NK) is a corneal degeneration associated with corneal nerve dysfunction. It can cause corneal epithelial defects, stromal thinning, and perforation. However, it is not clear if and to ...

    • Depletion of Passenger Leukocytes from Corneal Grafts: An Effective Means of Promoting Transplant Survival? 

      Zhang, Xian; Shen, Linling; Jin, Yiping; Saban, Daniel R.; Chauhan, Sunil Kumar; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2009)
      Purpose To develop and compare effective strategies for depleting graft-derived passenger leukocytes which include antigen-presenting cells from corneal buttons, and to assess the effectiveness of this strategy in ...

    • Dry Eye Disease: an immune-mediated ocular surface disorder 

      Stevenson, William; Chauhan, Sunil Kumar; Dana, Reza (American Medical Association (AMA), 2012)
      Dry eye disease is a multifactorial disorder of the tears and ocular surface characterized by symptoms of dryness and irritation. Although the pathogenesis of dry eye disease is not fully understood, it is recognized that ...

    • E-Selectin Mediates Immune Cell Trafficking in Corneal Transplantation 

      Dohlman, Thomas H.; Di Zazzo, Antonio; Omoto, Masahiro; Hua, Jing; Ding, Julia; Hamrah, Pedram; Chauhan, Sunil Kumar; Dana, Reza (Ovid Technologies (Wolters Kluwer Health), 2016)
      Background Immune rejection continues to threaten all tissue transplants. Here we sought to determine whether P- and E- selectin mediate T cell recruitment in corneal transplantation and whether their blockade can reduce ...

    • Effect of Desiccating Environmental Stress Versus Systemic Muscarinic AChR Blockade on Dry Eye Immunopathogenesis 

      Chen, Yihe; Chauhan, Sunil Kumar; Lee, Hyun Soo; Stevenson, William; Schaumburg, Chris S.; Sadrai, Zahra; Saban, Daniel R.; Kodati, Shilpa; Stern, Michael E.; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2013)
      Purpose. A majority of experimental data on dry eye disease (DED) immunopathogenesis have been derived from a murine model of DED that combines desiccating environmental stress with systemic muscarinic acetylcholine ...