Browsing by Author "Maruvka, Yosef"

Now showing items 1-5 of 5

    • Analysis of Somatic Microsatellite Indels Identifies Driver Events in Human Tumors 

      Maruvka, Yosef; Mouw, Kent; Karlic, Rosa; Parasuraman, Prasanna; Kamburov, Atanas; Polak, Paz; Haradhvala, Nicholas; Hess, Julian; Rheinbay, Esther; Brody, Yehuda; Koren, Amnon; Braunstein, Lior; D'Andrea, Alan; Lawrence, Michael; Bass, Adam; Bernards, Andre; Michor, Franziska; Getz, Gad (Springer Science and Business Media LLC, 2017-09-11)
      Microsatellites (MSs) are tracts of variable-length repeats of short DNA motifs that exhibit high rates of mutation in the form of insertions or deletions (indels) of the repeated motif. Despite their prevalence, the ...

    • Stochastic Tunneling of Two Mutations in a Population of Cancer Cells 

      Haeno, Hiroshi; Maruvka, Yosef E.; Iwasa, Yoh; Michor, Franziska (Public Library of Science, 2013)
      Cancer initiation, progression, and the emergence of drug resistance are driven by specific genetic and/or epigenetic alterations such as point mutations, structural alterations, DNA methylation and histone modification ...

    • Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition 

      Hata, Aaron N; Niederst, Matthew J; Archibald, Hannah L; Gomez-Caraballo, Maria; Siddiqui, Faria M; Mulvey, Hillary E; Maruvka, Yosef E; Ji, Fei; Bhang, Hyo-eun C; Radhakrishna, Viveksagar Krishnamurthy; Siravegna, Giulia; Hu, Haichuan; Raoof, Sana; Lockerman, Elizabeth; Kalsy, Anuj; Lee, Dana; Keating, Celina L; Ruddy, David A; Damon, Leah J; Crystal, Adam S; Costa, Carlotta; Piotrowska, Zofia; Bardelli, Alberto; Iafrate, Anthony J; Sadreyev, Ruslan I; Stegmeier, Frank; Getz, Gad; Sequist, Lecia V; Faber, Anthony C; Engelman, Jeffrey A (2016)
      Although mechanisms of acquired resistance of EGFR mutant non-small cell lung cancers to EGFR inhibitors have been identified, little is known about how resistant clones evolve during drug therapy. Here, we observe that ...

    • WRN Helicase is a Synthetic Lethal Target in Microsatellite Unstable Cancers 

      Bass, Adam; Chan, Edmond; Shibue, Tsukasa; McFarland, James; Gaeta, Benjamin; Ghandi, Mahmoud; Dumont, Nancy; Gonzalez, Alfredo; McPartlan, Justine; Li, Tianxia; Zhang, Yanxi; Liu, Jie Bin; Lazaro, Jean-Bernard; Gu, Peili; Piett, Cortt; Apffel, Annie; Ali, Syed Omar; Deasy, Rebecca; Keskula, Paula; Ng, Raymond; Roberts, Emma; Reznichenko, Elizaveta; Leung, Lisa; Alimova, Maria; Schenone, Monica; Islam, Manirul; Maruvka, Yosef; Liu, Yang; Roper, Jatin; Raghavan, Srivatsan; Giannakis, Marios; Tseng, Yuen-Yi; Nagel, Zachary; D’Andrea, Alan; Root, David; Boehm, Jesse; Getz, Gad; Chang, Sandy; Golub, Todd; Tsherniak, Aviad; Vazquez, Francisca (Cold Spring Harbor Laboratory, 2018-12-21)
      Synthetic lethality, an interaction whereby the co-occurrence of two genetic events leads to cell death but one event alone does not, can be exploited for cancer therapeutics1. DNA repair processes represent attractive ...

    • You Name It – How Memory and Delay Govern First Name Dynamics 

      Kessler, David A.; Maruvka, Yosef E.; Ouren, Jøergen; Shnerb, Nadav M. (Public Library of Science, 2012)
      The adoption and abandonment of first names through time is a fascinating phenomenon that may shed light on social dynamics and the forces that determine cultural taste in general. Here we show that baby name dynamics is ...