Now showing items 1-3 of 3

    • PD-L1 Regulates the Development, Maintenance, and Function of Induced Regulatory T Cells 

      Francisco, Loise Marie; Salinas, Victor H.; Brown, Keturah Elise; Vanguri, Vijay K.; Freeman, Gordon James; Kuchroo, Vijay Kumar; Sharpe, Arlene Helen (The Rockefeller University Press, 2009)
      Both the programmed death (PD) 1–PD-ligand (PD-L) pathway and regulatory T (T reg) cells are instrumental to the maintenance of peripheral tolerance. We demonstrate that PD-L1 has a pivotal role in regulating induced T reg ...
    • The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment 

      Sharma, Madhav D.; Shinde, Rahul; McGaha, Tracy L.; Huang, Lei; Holmgaard, Rikke B.; Wolchok, Jedd D.; Mautino, Mario R.; Celis, Esteban; Sharpe, Arlene H.; Francisco, Loise M.; Powell, Jonathan D.; Yagita, Hideo; Mellor, Andrew L.; Blazar, Bruce R.; Munn, David H. (American Association for the Advancement of Science, 2015)
      The tumor microenvironment is profoundly immunosuppressive. We show that multiple tumor types create intratumoral immune suppression driven by a specialized form of regulatory T cell (Treg) activation dependent on the PTEN ...
    • RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance 

      Xiao, Yanping; Yu, Sanhong; Zhu, Baogong; Bedoret, Denis; Bu, Xia; Francisco, Loise M.; Hua, Ping; Duke-Cohan, Jonathan S.; Umetsu, Dale T.; Sharpe, Arlene H.; DeKruyff, Rosemarie H.; Freeman, Gordon J. (The Rockefeller University Press, 2014)
      We report that programmed death ligand 2 (PD-L2), a known ligand of PD-1, also binds to repulsive guidance molecule b (RGMb), which was originally identified in the nervous system as a co-receptor for bone morphogenetic ...