Now showing items 1-19 of 19

    • \(\beta\)-Cell Hyperplasia Induced by Hepatic Insulin Resistance 

      Escribano, Oscar; Guillén, Carlos; Nevado, Carmen; Gómez-Hernández, Almudena; Kahn, C. Ronald; Benito, Manuel (American Diabetes Association, 2009)
      Objective: Type 2 diabetes results from a combination of insulin resistance and impaired insulin secretion. To directly address the effects of hepatic insulin resistance in adult animals, we developed an inducible ...
    • Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction 

      Stoeckel, Luke E.; Arvanitakis, Zoe; Gandy, Sam; Small, Dana; Kahn, C. Ronald; Pascual-Leone, Alvaro; Pawlyk, Aaron; Sherwin, Robert; Smith, Philip (F1000Research, 2016)
      Scientific evidence has established several links between metabolic and neurocognitive dysfunction, and epidemiologic evidence has revealed an increased risk of Alzheimer’s disease and vascular dementia in patients with ...
    • Dietary Leucine - An Environmental Modifier of Insulin Resistance Acting on Multiple Levels of Metabolism 

      Macotela, Yazmin; Emanuelli, Brice; Bång, Anneli M.; Espinoza, Daniel O.; Boucher, Jeremie; Beebe, Kirk; Gall, Walter; Kahn, C. Ronald (Public Library of Science, 2011)
      Environmental factors, such as the macronutrient composition of the diet, can have a profound impact on risk of diabetes and metabolic syndrome. In the present study we demonstrate how a single, simple dietary factor—leucine—can ...
    • Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity 

      Vienberg, Sara Gry; Kleinridders, André; Suzuki, Ryo; Kahn, C. Ronald (Elsevier, 2014)
      Objective: Lipoprotein lipase (LPL) is a key regulator of circulating triglyceride rich lipoprotein hydrolysis. In brain LPL regulates appetite and energy expenditure. Angiopoietin-like 4 (Angptl4) is a secreted protein ...
    • Fat-specific Dicer deficiency accelerates aging and mitigates several effects of dietary restriction in mice 

      Reis, Felipe C. G.; Branquinho, Jéssica L. O.; Brandão, Bruna B.; Guerra, Beatriz A.; Silva, Ismael D.; Frontini, Andrea; Thomou, Thomas; Sartini, Loris; Cinti, Saverio; Kahn, C. Ronald; Festuccia, William T.; Kowaltowski, Alicia J.; Mori, Marcelo A. (Impact Journals LLC, 2016)
      Aging increases the risk of type 2 diabetes, and this can be prevented by dietary restriction (DR). We have previously shown that DR inhibits the downregulation of miRNAs and their processing enzymes - mainly Dicer - that ...
    • Impaired Thermogenesis and Adipose Tissue Development in Mice with Fat-Specific Disruption of Insulin and IGF-1 Signalling 

      Boucher, Jeremie; Mori, Marcelo A.; Lee, Kevin Y.; Smyth, Graham; Liew, Chong-Wee; Macotela, Yazmin; Rourk, Michael; Bluher, Matthias; Russell, Steven J.; Kahn, C. Ronald (Nature Publishing Group, 2012)
      Insulin and insulin-like growth factor 1 (IGF-1) play important roles in adipocyte differentiation, glucose tolerance and insulin sensitivity. Here, to assess how these pathways can compensate for each other, we created ...
    • Insulin Action in Brain Regulates Systemic Metabolism and Brain Function 

      Kleinridders, André; Ferris, Heather A.; Cai, Weikang; Kahn, C. Ronald (American Diabetes Association, 2014)
      Insulin receptors, as well as IGF-1 receptors and their postreceptor signaling partners, are distributed throughout the brain. Insulin acts on these receptors to modulate peripheral metabolism, including regulation of ...
    • Insulin Augmentation of Glucose-Stimulated Insulin Secretion Is Impaired in Insulin-Resistant Humans 

      Halperin, Florencia; Lopez, Ximena; Manning, Raquel; Kahn, C. Ronald; Kulkarni, Rohit Narayan; Goldfine, Allison Braunwald (American Diabetes Association, 2012)
      Type 2 diabetes (T2D) is characterized by insulin resistance and pancreatic β-cell dysfunction, the latter possibly caused by a defect in insulin signaling in β-cells. We hypothesized that insulin’s effect to potentiate ...
    • Insulin Resistance in Human iPS Cells Reduces Mitochondrial Size and Function 

      Burkart, Alison M.; Tan, Kelly; Warren, Laura; Iovino, Salvatore; Hughes, Katelyn J.; Kahn, C. Ronald; Patti, Mary-Elizabeth (Nature Publishing Group, 2016)
      Insulin resistance, a critical component of type 2 diabetes (T2D), precedes and predicts T2D onset. T2D is also associated with mitochondrial dysfunction. To define the cause-effect relationship between insulin resistance ...
    • Interactions between host genetics and gut microbiome in diabetes and metabolic syndrome 

      Ussar, Siegfried; Fujisaka, Shiho; Kahn, C. Ronald (Elsevier, 2016)
      Background: Diabetes, obesity, and the metabolic syndrome are multifactorial diseases dependent on a complex interaction of host genetics, diet, and other environmental factors. Increasing evidence places gut microbiota ...
    • Intrinsic Differences in Adipocyte Precursor Cells From Different White Fat Depots 

      Macotela, Yazmín; Emanuelli, Brice; Mori, Marcelo A.; Gesta, Stephane; Schulz, Tim J.; Tseng, Yu-Hua; Kahn, C. Ronald (American Diabetes Association, 2012)
      Obesity and body fat distribution are important risk factors for the development of type 2 diabetes and metabolic syndrome. Evidence has accumulated that this risk is related to intrinsic differences in behavior of adipocytes ...
    • Lessons on Conditional Gene Targeting in Mouse Adipose Tissue 

      Lee, Kevin Y.; Russell, Steven J.; Ussar, Siegfried; Boucher, Jeremie; Vernochet, Cecile; Mori, Marcelo A.; Smyth, Graham; Rourk, Michael; Cederquist, Carly; Rosen, Evan D.; Kahn, Barbara B.; Kahn, C. Ronald (American Diabetes Association, 2013)
      Conditional gene targeting has been extensively used for in vivo analysis of gene function in adipocyte cell biology but often with debate over the tissue specificity and the efficacy of inactivation. To directly compare ...
    • Loss of Insulin Receptor in Osteoprogenitor Cells Impairs Structural Strength of Bone 

      Thrailkill, Kathryn; Bunn, R. Clay; Lumpkin, Charles; Wahl, Elizabeth; Cockrell, Gael; Morris, Lindsey; Kahn, C. Ronald; Fowlkes, John; Nyman, Jeffry S. (Hindawi Publishing Corporation, 2014)
      Type 1 diabetes mellitus (T1D) is associated with decreased bone mineral density, a deficit in bone structure, and subsequently an increased risk of fragility fracture. These clinical observations, paralleled by animal ...
    • Loss of Insulin Signaling in Vascular Endothelial Cells Accelerates Atherosclerosis in Apolipoprotein E Null Mice 

      Rask-Madsen, Christian; Li, Qian; Freund, Bryn; Feather, Danielle; Abramov, Roman; Wu, I-Hsien; Chen, Kai; Yamamoto-Hiraoka, Junko; Goldenbogen, Jan; Sotiropoulos, Konstantinos B.; Clermont, Allen Charles; Geraldes, Pedro; Dall, Claudia; Wagers, Amy Jo; Huang, Paul Lee; Rekhter, Mark; Scalia, Rosario; Kahn, C. Ronald; King, George Liang (Elsevier BV, 2010)
      To determine whether insulin action on endothelial cells promotes or protects against atherosclerosis, we generated apolipoprotein E null mice in which the insulin receptor gene was intact or conditionally deleted in ...
    • Mitochondria, obesity and aging 

      Vernochet, Cecile; Kahn, C. Ronald (Impact Journals LLC, 2012)
    • Myeloid Cell-Restricted Insulin Receptor Deficiency Protects Against Obesity-Induced Inflammation and Systemic Insulin Resistance 

      Mauer, Jan; Chaurasia, Bhagirath; Plum, Leona; Quast, Thomas; Hampel, Brigitte; Blüher, Matthias; Kolanus, Waldemar; Kahn, C. Ronald; Brüning, Jens C. (Public Library of Science, 2010)
      A major component of obesity-related insulin resistance is the establishment of a chronic inflammatory state with invasion of white adipose tissue by mononuclear cells. This results in the release of pro-inflammatory ...
    • Reduction of the Cholesterol Sensor SCAP in the Brains of Mice Causes Impaired Synaptic Transmission and Altered Cognitive Function 

      Suzuki, Ryo; Ferris, Heather; Chee, Melissa; Maratos-Flier, Eleftheria; Kahn, C. Ronald (Public Library of Science, 2013)
      The sterol sensor SCAP is a key regulator of SREBP-2, the major transcription factor controlling cholesterol synthesis. Recently, we showed that there is a global down-regulation of cholesterol synthetic genes, as well as ...
    • Role of Vascular Endothelial Growth Factor Signaling in Brown Adipocyte Survival, Proliferation and Function 

      Bagchi, Mandrita (2013-03-15)
      Both white and brown adipose tissues exhibit extensive vascularity. Increased angiogenesis in brown adipose tissue (BAT) is crucial for brown fat activation and thermogenesis in animals during cold acclimation. BAT can be ...
    • Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism 

      Lee, Kevin Y.; Singh, Manvendra K.; Ussar, Siegfried; Wetzel, Petra; Hirshman, Michael F.; Goodyear, Laurie J.; Kispert, Andreas; Kahn, C. Ronald (Nature Pub. Group, 2015)
      Skeletal muscle is composed of both slow-twitch oxidative myofibers and fast-twitch glycolytic myofibers that differentially impact muscle metabolism, function and eventually whole-body physiology. Here we show that the ...