Browsing by Author "Choi, Jeong-Mo"
Now showing items 1-6 of 6
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Graph’s Topology and Free Energy of a Spin Model on the Graph
Choi, Jeong-Mo; Gilson, Amy Ilana; Shakhnovich, Eugene Isaacovitch (American Physical Society (APS), 2017)In this work we show that there is a direct relationship between a graph's topology and the free energy of a spin system on the graph. We develop a method of separating topological and enthalpic contributions to the free ... -
Influenza A H1N1 Pandemic Strain Evolution – Divergence and the Potential for Antigenic Drift Variants
Klein, Eili Y.; Serohijos, Adrian W. R.; Choi, Jeong-Mo; Shakhnovich, Eugene I.; Pekosz, Andrew (Public Library of Science, 2014)The emergence of a novel A(H1N1) strain in 2009 was the first influenza pandemic of the genomic age, and unprecedented surveillance of the virus provides the opportunity to better understand the evolution of influenza. We ... -
Multi-Scale Theoretical Investigations of Protein Interactions and Evolution
Choi, Jeong-Mo (2016-05-12)Evolution of biological systems requires players of multiple layers, from atoms and molecules to organisms and populations. Expression of a gene is operated by molecular machineries for transcription, translation, regulation, ... -
Protein Homeostasis Imposes a Barrier on Functional Integration of Horizontally Transferred Genes in Bacteria
Bershtein, Shimon; Serohijos, Adrian W. R.; Bhattacharyya, Sanchari; Manhart, Michael; Choi, Jeong-Mo; Mu, Wanmeng; Zhou, Jingwen; Shakhnovich, Eugene I. (Public Library of Science, 2015)Horizontal gene transfer (HGT) plays a central role in bacterial evolution, yet the molecular and cellular constraints on functional integration of the foreign genes are poorly understood. Here we performed inter-species ... -
Protein Homeostasis Imposes a Barrier on Functional Integration of Horizontally Transferred Genes in Bacteria
Bershtein, Shimon; Serohijos, Adrian W. R.; Bhattacharyya, Sanchari; Manhart, Michael; Choi, Jeong-Mo; Mu, Wanmeng; Zhou, Jingwen; Shakhnovich, Eugene I. (Public Library of Science, 2015)Horizontal gene transfer (HGT) plays a central role in bacterial evolution, yet the molecular and cellular constraints on functional integration of the foreign genes are poorly understood. Here we performed inter-species ... -
Systems-Level Response to Point Mutations in a Core Metabolic Enzyme Modulates Genotype-Phenotype Relationship
Bershtein, Shimon; Choi, Jeong-Mo; Bhattacharyya, Sanchari; Budnik, Bogdan; Shakhnovich, Eugene Isaacovitch (Elsevier BV, 2015)Linking the molecular effects of mutations to fitness is central to understanding evolutionary dynamics. Here we establish a quantitative relation between the global effect of mutations on the E. coli proteome and bacterial ...