Now showing items 1-10 of 10

    • B cell homeostasis and follicle confines are governed by fibroblastic reticular cells 

      Cremasco, Viviana; Woodruff, Matthew C.; Onder, Lucas; Cupovic, Jovana; Nieves-Bonilla, Janice M.; Schildberg, Frank A.; Chang, Jonathan; Cremasco, Floriana; Harvey, Christopher J.; Wucherpfennig, Kai; Ludewig, Burkhard; Carroll, Michael C.; Turley, Shannon J. (2014)
      Fibroblastic reticular cells (FRCs) are known to inhabit T cell-rich areas of lymphoid organs where they function to coordinate T cell and dendritic cell interactions. However, in vivo manipulation of FRCs has been limited ...
    • Bacteria activate sensory neurons that modulate pain and inflammation 

      Chiu, Isaac M.; Heesters, Balthasar A.; Ghasemlou, Nader; Von Hehn, Christian A.; Zhao, Fan; Tran, Johnathan; Wainger, Brian; Strominger, Amanda; Muralidharan, Sriya; Horswill, Alexander R.; Wardenburg, Juliane Bubeck; Hwang, Sun Wook; Carroll, Michael C.; Woolf, Clifford J. (2013)
      Summary Nociceptor sensory neurons are specialized to detect potentially damaging stimuli, protecting the organism by initiating the sensation of pain and eliciting defensive behaviors. Bacterial infections produce pain ...
    • Circulating C3 is Necessary and Sufficient for Induction of Autoantibody-Mediated Arthritis in a Mouse Model 

      Monach, Paul A; Verschoor, Admar; Jacobs, Jonathan P; Carroll, Michael C.; Wagers, Amy Jo; Benoist, Christophe O.; Mathis, Diane J. (John Wiley & Sons, 2007)
      Objective. For the inflammation characteristic of rheumatoid arthritis, the relative contribution of mediators produced locally in the synovium versus those circulating systemically is unknown. Complement factor C3 is made ...
    • The CLEC-2–podoplanin axis controls fibroblastic reticular cell contractility and lymph node microarchitecture 

      Astarita, Jillian L.; Cremasco, Viviana; Fu, Jianxin; Darnell, Max C.; Peck, James R.; Nieves-Bonilla, Janice M.; Song, Kai; Woodruff, Matthew C.; Gogineni, Alvin; Onder, Lucas; Ludewig, Burkhard; Weimer, Robby M.; Carroll, Michael C.; Mooney, David J.; Xia, Lijun; Turley, Shannon J. (2014)
      In lymph nodes, fibroblastic reticular cells (FRCs) form a collagen-based reticular network that supports migratory dendritic cells (DCs) and T cells and transports lymph. A hallmark of FRCs is their propensity to contract ...
    • Follicular Dendritic Cells Retain Infectious HIV in Cycling Endosomes 

      Heesters, Balthasar A.; Lindqvist, Madelene; Vagefi, Parsia A.; Scully, Eileen P.; Schildberg, Frank A.; Altfeld, Marcus; Walker, Bruce D.; Kaufmann, Daniel E.; Carroll, Michael C. (Public Library of Science, 2015)
      Despite the success of antiretroviral therapy (ART), it does not cure Human Immunodeficiency Virus (HIV) and discontinuation results in viral rebound. Follicular dendritic cells (FDC) are in direct contact with CD4+ T cells ...
    • Individual Microbes Shape Various Parts of the Immune System 

      Sefik, Esen (2015-09-22)
      The gastrointestinal tract, home to a vast number of bacteria, requires finely-tuned regulatory and effector immune mechanisms to maintain homeostasis and tolerance. In a large-scale screen, we studied the impacts of single ...
    • Regulation of Effector CD8+ T Cells During Mycobacterium Tuberculosis Infection 

      Booty, Matthew Gregory (2015-05-18)
      Approximately one-third of the world’s population is currently infected with Mycobacterium tuberculosis (Mtb), the bacillus that causes tuberculosis. Globally, it is the second leading cause of death by a single infectious ...
    • The Role of Sialic Acid Acetylesterase in the Maintenance of B Cell Self Tolerance 

      McQuay, Amy Brook (2015-03-25)
      Abstract Sialic acid acetylesterase (SIAE) removes 9-O-acetyl moieties from acetylated sialic acids. The B cell receptor (BCR) inhibitory receptor CD22 cannot bind 9-O-acetylated α2-6-linked sialic acid-containing ligands. ...
    • Trans-nodal migration of resident dendritic cells into medullary interfollicular regions initiates immunity to influenza vaccine 

      Woodruff, Matthew C.; Heesters, Balthasar A.; Herndon, Caroline N.; Groom, Joanna R.; Thomas, Paul G.; Luster, Andrew D.; Turley, Shannon J.; Carroll, Michael C. (The Rockefeller University Press, 2014)
      Dendritic cells (DCs) are well established as potent antigen-presenting cells critical to adaptive immunity. In vaccination approaches, appropriately stimulating lymph node–resident DCs (LNDCs) is highly relevant to effective ...
    • Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks 

      Malhotra, Deepali; Fletcher, Anne; Astarita, Jillian Leigh; Lukacs-Kornek, Veronika; Tayalia, Prakriti; Gonzalez, Santiago F.; Elpek, Kutlu G.; Chang, Sook Kyung; Knoblich, Konstantin; Hemler, Martin Edward; Brenner, Michael Barry; Carroll, Michael C.; Mooney, David J.; Turley, Shannon J. (Nature Publishing Group, 2012)
      Lymph node stromal cells (LNSCs) closely regulate immunity and self-tolerance, yet key aspects of their biology remain poorly illuminated. Comparative transcriptomic analyses of murine LNSC subsets revealed expression of ...