Now showing items 1-13 of 13

    • Antiproliferative Factor Signaling and Interstitial Cystitis/Painful Bladder Syndrome 

      Kim, Jayoung; Freeman, Michael R. (Korean Continence Society, 2011)
      A unique glycopeptide, antiproliferative factor (APF), has been suggested as a urinary biomarker and potential mediator of long-term bladder disorder Interstitial Cystitis/Painful Bladder Syndrome. There is no known cause ...
    • Assess the expression of ubiquitin specific protease USP2a for bladder cancer diagnosis 

      Jeong, Pildu; Ha, Yun-Sok; Yun, Seok-Joong; Yoon, Hyung Yoon; Freeman, Michael R.; Kim, Jayoung; Kim, Wun-Jae (BioMed Central, 2015)
      Background: Given that a deubiquitinating enzyme, ubiquitin-specific protease 2a (USP2a), regulates ubiquitination, trafficking, and degradation of EGFR, which plays a critical role in bladder cancer, in this study, we ...
    • DIAPH3 Governs the Cellular Transition to the Amoeboid Tumour Phenotype 

      Hager, Martin H; Morley, Samantha; Bielenberg, Diane R; Gao, Sizhen; Morello, Matteo; Holcomb, Ilona N; Liu, Wennuan; Mouneimne, Ghassan; Demichelis, Francesca; Kim, Jayoung; Solomon, Keith R; Adam, Rosalyn M; Isaacs, William B; Higgs, Henry N; Vessella, Robert L; Di Vizio, Dolores; Freeman, Michael R (WILEY-VCH Verlag, 2012)
      Therapies for most malignancies are generally ineffective once metastasis occurs. While tumour cells migrate through tissues using diverse strategies, the signalling networks controlling such behaviours in human tumours ...
    • Drug delivery systems in urology—getting “smarter” 

      Farokhzad, Omid Cameron; Dimitrakov, Jordan D.; Karp, Jeffrey MIchael; Khademhosseini, Ali; Freeman, Michael; Langer, Robert S. (Elsevier BV, 2006)
      Urology holds the most enviable position in the medical firmament. Unique among specialties in bringing the surgeon in contact with humans throughout the spectrum of human life—from newborn to geriatric patients—urologists ...
    • Impact of Circulating Cholesterol Levels on Growth and Intratumoral Androgen Concentration of Prostate Tumors 

      Mostaghel, Elahe A.; Solomon, Keith R.; Pelton, Kristine; Freeman, Michael R.; Montgomery, R. Bruce (Public Library of Science, 2012)
      Prostate cancer (PCa) is the second most common cancer in men. Androgen deprivation therapy (ADT) leads to tumor involution and reduction of tumor burden. However, tumors eventually reemerge that have overcome the absence ...
    • Integration of proteomic and transcriptomic profiles identifies a novel PDGF-MYC network in human smooth muscle cells 

      Yang, Wei; Ramachandran, Aruna; You, Sungyong; Jeong, HyoBin; Morley, Samantha; Mulone, Michelle D; Logvinenko, Tanya; Kim, Jayoung; Hwang, Daehee; Freeman, Michael R; Adam, Rosalyn M (BioMed Central, 2014)
      Background: Platelet-derived growth factor-BB (PDGF-BB) has been implicated in the proliferation, migration and synthetic activities of smooth muscle cells that characterize physiologic and pathologic tissue remodeling in ...
    • Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles 

      Minciacchi, Valentina R.; You, Sungyong; Spinelli, Cristiana; Morley, Samantha; Zandian, Mandana; Aspuria, Paul-Joseph; Cavallini, Lorenzo; Ciardiello, Chiara; Sobreiro, Mariana Reis; Morello, Matteo; Kharmate, Geetanjali; Jang, Su Chul; Kim, Dae-Kyum; Hosseini-Beheshti, Elham; Guns, Emma Tomlinson; Gleave, Martin; Gho, Yong Song; Mathivanan, Suresh; Yang, Wei; Freeman, Michael R.; Di Vizio, Dolores (Impact Journals LLC, 2015)
      Large oncosomes (LO) are atypically large (1-10μm diameter) cancer-derived extracellular vesicles (EVs), originating from the shedding of membrane blebs and associated with advanced disease. We report that 25% of the ...
    • Regulation of microtubule dynamics by DIAPH3 influences amoeboid tumor cell mechanics and sensitivity to taxanes 

      Morley, Samantha; You, Sungyong; Pollan, Sara; Choi, Jiyoung; Zhou, Bo; Hager, Martin H.; Steadman, Kenneth; Spinelli, Cristiana; Rajendran, Kavitha; Gertych, Arkadiusz; Kim, Jayoung; Adam, Rosalyn M.; Yang, Wei; Krishnan, Ramaswamy; Knudsen, Beatrice S.; Di Vizio, Dolores; Freeman, Michael R. (Nature Publishing Group, 2015)
      Taxanes are widely employed chemotherapies for patients with metastatic prostate and breast cancer. Here, we show that loss of Diaphanous-related formin-3 (DIAPH3), frequently associated with metastatic breast and prostate ...
    • The Response of the Prostate to Circulating Cholesterol: Activating Transcription Factor 3 (ATF3) as a Prominent Node in a Cholesterol-Sensing Network 

      Vizio, Dolores Di; Kim, Taek-Kyun; Kim, Jonghwan; Pelton, Kristine; Clinton, Steven K.; Hai, Tsonwin; Hwang, Daehee; Kim, Jayoung; Kim, Minjung; Solomon, Keith R.; Freeman, Michael R. (Public Library of Science, 2012)
      Elevated circulating cholesterol is a systemic risk factor for cardiovascular disease and metabolic syndrome, however the manner in which the normal prostate responds to variations in cholesterol levels is poorly understood. ...
    • Skp2 Expression is Associated with High Risk and Elevated Ki67 Expression in Gastrointestinal Stromal Tumours 

      Di Vizio, Dolores; Demichelis, Francesca; Simonetti, Sara; Pettinato, Guido; Terracciano, Luigi; Tornillo, Luigi; Freeman, Michael R.; Insabato, Luigi (BioMed Central, 2008)
      Background: Gastrointestinal stromal tumors (GIST) exhibit an unpredictable clinical course and can rapidly progress to lethality. Predictions about the biological behavior of GIST are based on a number of canonical clinical ...
    • A Synthetic Form of Frizzled 8-Associated Antiproliferative Factor Enhances p53 Stability through USP2a and MDM2 

      Kim, Jayoung; Keay, Susan K.; You, Sungyong; Loda, Massimo; Freeman, Michael R. (Public Library of Science, 2012)
      Frizzled 8-associated Antiproliferative Factor (APF) is a sialoglycopeptide urinary biomarker of interstitial cystitis/painful bladder syndrome (IC/PBS), a chronic condition of unknown etiology with variable symptoms that ...
    • Trading in your spindles for blebs: the amoeboid tumor cell phenotype in prostate cancer 

      Morley, Samantha; Hager, Martin H; Pollan, Sara G; Knudsen, Beatrice; Di Vizio, Dolores; Freeman, Michael R (Medknow Publications & Media Pvt Ltd, 2014)
      Prostate cancer (PCa) remains a principal cause of mortality in developed countries. Because no clinical interventions overcome resistance to androgen ablation therapy, management of castration resistance and metastatic ...
    • Urinary Metabolite Profiling Combined with Computational Analysis Predicts Interstitial Cystitis-Associated Candidate Biomarkers 

      Wen, He; Lee, Tack; You, Sungyong; Park, Soo-Hwan; Song, Hosook; Eilber, Karyn S.; Anger, Jennifer T.; Freeman, Michael R.; Park, Sunghyouk; Kim, Jayoung (American Chemical Society, 2014)
      Interstitial cystitis/painful bladder syndrome (IC) is a chronic syndrome of unknown etiology that presents with bladder pain, urinary frequency, and urgency. The lack of specific biomarkers and a poor understanding of ...