Now showing items 1-10 of 10

    • Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1–Specific CD8+ T Cells 

      Brumme, Zabrina L; Anastario, Michael; Cohen, Kristin W; Jolin, Jonathan S; Brumme, Chanson J; Streeck, Hendrik; Meier, Angela; Rosenberg, Eric Scott; Alter, Galit; Allen, Todd; Walker, Bruce David; Altfeld, Marcus (Public Library of Science, 2008)
      Background: Virus-specific CD8+ T lymphocytes play a key role in the initial reduction of peak viremia during acute viral infections, but display signs of increasing dysfunction and exhaustion under conditions of chronic ...
    • Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence 

      Schulze zur Wiesch, Julian; Ciuffreda, Donatella; Lewis-Ximenez, Lia; Kasprowicz, Victoria Olivia; Nolan, Brian E.; Streeck, Hendrik; Aneja, Jasneet; Reyor, Laura L.; Allen, Todd; Lohse, Ansgar W.; McGovern, Barbara; Chung, Raymond Taeyong; Kwok, William W.; Kim, Arthur Yu-Shin; Lauer, Georg (The Rockefeller University Press, 2012)
      Vigorous proliferative CD4+ T cell responses are the hallmark of spontaneous clearance of acute hepatitis C virus (HCV) infection, whereas comparable responses are absent in chronically evolving infection. Here, we ...
    • HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1 

      Kalife, Elizabeth T; Qi, Ying; Johnston, Mary N; Burgett, Nicole; Swartz, Martha E; Yang, Amy; Rockstroh, Juergen K; Jessen, Heiko; Carrington, Mary; Altfeld, Marcus; Streeck, Hendrik; Lichterfeld, Mathias; Alter, Galit; Yu, Xu; Meier, Angela; Allen, Todd; Rosenberg, Eric Scott; Walker, Bruce David (Public Library of Science, 2006)
      Background: Very little is known about the immunodominance patterns of HIV-1-specific T cell responses during primary HIV-1 infection and the reasons for human lymphocyte antigen (HLA) modulation of disease progression. ...
    • Immune-Driven Recombination and Loss of Control after HIV Superinfection 

      Streeck, Hendrik; Li, Bin; Poon, Art F. Y.; Schneidewind, Anne; Gladden, Adrianne D.; Power, Karen A.; Daskalakis, Demetre; Bazner, Suzane; Zuniga, Rosario; Brander, Christian; Rosenberg, Eric Scott; Frost, Simon D. W.; Altfeld, Marcus; Allen, Todd (The Rockefeller University Press, 2008)
      After acute HIV infection, CD8^{+} T cells are able to control viral replication to a set point. This control is often lost after superinfection, although the mechanism behind this remains unclear. In this study, we ...
    • Immunodominant HIV-1 Cd4+ T Cell Epitopes in Chronic Untreated Clade C HIV-1 Infection 

      Ramduth, Danni; Day, Cheryl L.; Thobakgale, Christina F.; Mkhwanazi, Nompumelelo P.; de Pierres, Chantal; Reddy, Sharon; van der Stok, Mary; Mncube, Zenele; Nair, Kriebashne; Moodley, Eshia S.; Coovadia, Hoosen M.; Kiepiela, Photini; Kaufmann, Daniel; Streeck, Hendrik; Goulder, Philip J.; Walker, Bruce David (Public Library of Science, 2009)
      Background: A dominance of Gag-specific CD8+ T cell responses is significantly associated with a lower viral load in individuals with chronic, untreated clade C human immunodeficiency virus type 1 (HIV-1) infection. This ...
    • OA031-04. Impairment of HIV-1-specific CD8+ T cell function by soluble epithelial adhesion molecules 

      Trocha, K; Chevalier, M; Caron, T; Pyo, A; Toth, I; Rodig, SJ; Streeck, Hendrik; Kwon, Douglas; Jolin, Julie Ann; Law, Kayee; Kaufmann, Daniel; Walker, Bruce David; Altfeld, Marcus (BioMed Central, 2009)
    • P09-20 LB. Ultra-Deep Sequencing of Full-Length HIV-1 Genomes Identifies Rapid Viral Evolution During Acute Infection 

      Henn, MR; Lennon, N; Malboeuf, C; Charlebois, P; Philips, L; Berical, A; Erlich, R; Kemper, M; Axten, K; Brumme, Z; Brumme, C; Jessen, H; Nusbaum, C; Birren, B; Allen, TM; Boutwell, Christian Lane; Power, K; Gladden, Andrew B; Levin, Jonathan M.; Casali, Monica; Berlin, A; Anderson, S; Streeck, Hendrik; Ryan, Edward Thomas; Wang, Y; Green, L; Russ, Christiana Marie; Rosenberg, Eric Scott; Altfeld, Marcus; Walker, Bruce David (BioMed Central, 2009)
    • P16-18. Regulatory T Cell Frequencies Correlate With T Cell Activation in Chronic HIV-1 Infection 

      Pyo, A; Trocha, A; Toth, I; Addo, MM; Angin, Mathieu; Streeck, Hendrik; Pereyra, Florencia M.; Walker, Bruce David; Altfeld, Marcus; Alter, G; Kwon, D; Wen, F (BioMed Central, 2009)
    • P16-31. Skewed HIV-1-Specific CD4+ Th2 Helper Cell Contribution in Progressive HIV-1 Infection 

      Chevalier, M; Pyo, A; Jolin, J. S.; Addo, Marylyn Martina; Kwon, DS; Toth, I; Walker, Bruce David; Streeck, Hendrik (BioMed Central, 2009)
    • Whole Genome Deep Sequencing of HIV-1 Reveals the Impact of Early Minor Variants Upon Immune Recognition During Acute Infection 

      Henn, Matthew R.; Charlebois, Patrick; Lennon, Niall J.; Power, Karen A.; Macalalad, Alexander R.; Berlin, Aaron M.; Malboeuf, Christine M.; Gnerre, Sante; Erlich, Rachel L.; Green, Lisa M.; Berical, Andrew; Wang, Yaoyu; Newman, Ruchi; Axten, Karen L.; Gladden, Adrianne D.; Battis, Laura; Kemper, Michael; Zeng, Qiandong; Shea, Terrance P.; Gujja, Sharvari; Zedlack, Carmen; Gasser, Olivier; Brander, Christian; Günthard, Huldrych F.; Brumme, Zabrina L.; Brumme, Chanson J.; Bazner, Suzane; Rychert, Jenna; Tinsley, Jake P.; Levin, Joshua Z.; Jessen, Heiko; Birren, Bruce W.; Boutwell, Christian Lane; Ryan, Elizabeth M.; Zody, Michael C.; Casali, Monica; Streeck, Hendrik; Bloom, Allyson Kelly; Dudek, Timothy E.; Tully, Damien C.; Hess, Christoph; Mayer, Kenneth Hugh; Rosenberg, Eric Scott; Pereyra, Florencia M.; Young, Sarah K.; Altfeld, Marcus; Walker, Bruce David; Allen, Todd (Public Library of Science, 2012)
      Deep sequencing technologies have the potential to transform the study of highly variable viral pathogens by providing a rapid and cost-effective approach to sensitively characterize rapidly evolving viral quasispecies. ...