Browsing by Author "Reddy, Vemuri"
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Cathepsin S Signals via PAR2 and Generates a Novel Tethered Ligand Receptor Agonist
Elmariah, Sarina B.; Reddy, Vemuri B.; Lerner, Ethan A. (Public Library of Science, 2014)Protease-activated receptor-2 is widely expressed in mammalian epithelial, immune and neural tissues. Cleavage of PAR2 by serine proteases leads to self-activation of the receptor by the tethered ligand SLIGRL. The ...