Now showing items 1-7 of 7

    • Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity 

      Bartelt, Alexander; Widenmaier, Scott Bradley; Schlein, Christian; Johann, Kornelia; Goncalves, Renata L.S.; Eguchi, Kosei; Fischer, Alexander W; Parlakgul, Gunes; Snyder, Nicole; Nguyen, Truc B; Bruns, Oliver T; Franke, Daniel; Bawendi, Moungi G; Lynes, Matthew David; Leiria, Luiz O; Tseng, Yu-Hua; Inouye, Karen; Arruda, Ana Paula; Hotamisligil, Gokhan S. (Springer Nature, 2018)
      Objective Brown adipose tissue (BAT) generates heat in response to cold, and low BAT activity has been linked to obesity. However, recent studies were inconclusive as to whether BAT is involved in diet‐induced thermogenesis ...
    • Clonal analyses and gene profiling identify genetic biomarkers of human brown and white preadipocyte thermogenic potential 

      Xue, Ruidan; Lynes, Matthew D.; Dreyfuss, Jonathan M.; Shamsi, Farnaz; Schulz, Tim J.; Zhang, Hongbin; Huang, Tian Lian; Townsend, Kristy L.; Li, Yiming; Takahashi, Hirokazu; Weiner, Lauren S.; White, Andrew P.; Lynes, Maureen S.; Rubin, Lee L.; Goodyear, Laurie J.; Cypess, Aaron M.; Tseng, Yu-Hua (2015)
      Targeting brown adipose tissue (BAT) content or activity has therapeutic potential for treating obesity and the metabolic syndrome by increasing energy expenditure. Both inter- and intra-individual differences contribute ...
    • The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue 

      Lynes, Matthew David; Leiria, Luiz; Lundh, Morten; Bartelt, Alexander; Shamsi, Farnaz; Huang, Tianwen; Takahashi, Hirokazu; Hirshman, Michael F; Schlein, Christian; Lee, Alexandra; Baer, Lisa A; May, Francis J; Gao, Fei; Narain, Niven R; Chen, Emily Y; Kiebish, Michael A; Cypess, Aaron; Blüher, Matthias; Goodyear, Laurie Joy; Hotamisligil, Gokhan S.; Stanford, Kristin I; Tseng, Yu-Hua (Springer Nature, 2017)
      Brown adipose tissue (BAT) and beige adipose tissue combust fuels for heat production in adult humans, and so constitute an appealing target for the treatment of metabolic disorders such as obesity, diabetes and ...
    • Curcumin analogues as selective fluorescence imaging probes for brown adipose tissue and monitoring browning 

      Zhang, Xueli; Tian, Yanli; Zhang, Hongbin; Kavishwar, Amol; Lynes, Matthew; Brownell, Anna-Liisa; Sun, Hongbin; Tseng, Yu-Hua; Moore, Anna; Ran, Chongzhao (Nature Publishing Group, 2015)
      Manipulation of brown adipose tissue (BAT) and browning of white adipose tissue (WAT) can be promising new approaches to counter metabolic disorder diseases in humans. Imaging probes that could consistently monitor BAT ...
    • Isolation of Progenitors that Exhibit Myogenic/Osteogenic Bipotency In Vitro by Fluorescence-Activated Cell Sorting from Human Fetal Muscle 

      Castiglioni, Alessandra; Hettmer, Simone; Lynes, Matthew David; Rao, Tata Nageswara; Tchessalova, Daria; Sinha, Indranil; Lee, Bernard Travis; Tseng, Yu-Hua; Wagers, Amy Jo (Elsevier BV, 2014)
      Fluorescence-activated cell sorting (FACS) strategies to purify distinct cell types from the pool of fetal human myofiber-associated (hMFA) cells were developed. We demonstrate that cells expressing the satellite cell ...
    • Loss of BMP receptor type 1A in murine adipose tissue attenuates age-related onset of insulin resistance 

      Schulz, Tim J.; Graja, Antonia; Huang, Tian Lian; Xue, Ruidan; An, Ding; Poehle-Kronawitter, Sophie; Lynes, Matthew D.; Tolkachov, Alexander; O’Sullivan, Lindsay E.; Hirshman, Michael F.; Schupp, Michael; Goodyear, Laurie J.; Mishina, Yuji; Tseng, Yu-Hua (Springer Berlin Heidelberg, 2016)
      Aims/hypothesis Adipose tissue dysfunction is a prime risk factor for the development of metabolic disease. Bone morphogenetic proteins (BMPs) have previously been implicated in adipocyte formation. Here, we investigate ...
    • Monoacylglycerol Analysis Using MS/MSALL Quadruple Time of Flight Mass Spectrometry 

      Gao, Fei; McDaniel, Justice; Chen, Emily Y.; Rockwell, Hannah; Lynes, Matthew D.; Tseng, Yu-Hua; Sarangarajan, Rangaprasad; Narain, Niven R.; Kiebish, Michael A. (MDPI, 2016)
      Monoacylglycerols (MAGs) are structural and bioactive metabolites critical for biological function. Development of facile tools for measuring MAG are essential to understand its role in different diseases and various ...