Browsing by Author "Hubbard, Troy P."
Now showing items 1-3 of 3
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Chemoproteomic profiling of host and pathogen enzymes active in cholera
Hatzios, Stavroula K.; Abel, Sören; Martell, Julianne; Hubbard, Troy; Sasabe, Jumpei; Munera, Diana; Clark, Lars; Bachovchin, Daniel A.; Qadri, Firdausi; Ryan, Edward T.; Davis, Brigid M.; Weerapana, Eranthie; Waldor, Matthew K. (2016)Activity-based protein profiling (ABPP) is a chemoproteomic tool for detecting active enzymes in complex biological systems. We used ABPP to identify secreted bacterial and host serine hydrolases that are active in animals ... -
Comparative RNA-Seq based dissection of the regulatory networks and environmental stimuli underlying Vibrio parahaemolyticus gene expression during infection
Livny, Jonathan; Zhou, Xiaohui; Mandlik, Anjali; Hubbard, Troy; Davis, Brigid M.; Waldor, Matthew K. (Oxford University Press, 2014)Vibrio parahaemolyticus is the leading worldwide cause of seafood-associated gastroenteritis, yet little is known regarding its intraintestinal gene expression or physiology. To date, in vivo analyses have focused on ... -
The Nucleoid Binding Protein H-NS Biases Genome-Wide Transposon Insertion Landscapes
Kimura, Satoshi; Hubbard, Troy P.; Davis, Brigid M.; Waldor, Matthew K. (American Society for Microbiology, 2016)ABSTRACT Transposon insertion sequencing (TIS; also known as TnSeq) is a potent approach commonly used to comprehensively define the genetic loci that contribute to bacterial fitness in diverse environments. A key presumption ...