Now showing items 1-20 of 165

    • 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) and mutagenic activity in Massachusetts drinking water. 

      Wright, J Michael; Schwartz, Joel David; Vartiainen, Terttu; Mäki-Paakkanen, Jorma; Altshul, Larisa M.; Harrington, Joseph J; Dockery, Douglas W. (2002)
      There is limited information on the prevalence of the potent mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in U.S. water supplies. We measured MX concentrations and mutagenic activity in tap water samples ...
    • Acclimatization across space and time in the effects of temperature on mortality: a time-series analysis 

      Lee, Mihye; Nordio, Francesco; Zanobetti, Antonella; Kinney, Patrick; Vautard, Robert; Schwartz, Joel (BioMed Central, 2014)
      Background: Climate change has increased the days of unseasonal temperature. Although many studies have examined the association between temperature and mortality, few have examined the timing of exposure where whether ...
    • Acute and Chronic Effects of Particles on Hospital Admissions in New England 

      Coull, Brent Andrew; Zanobetti, Antonella; Koutrakis, Petros; Schwartz, Joel David (Public Library of Science, 2012)
      Background: Many studies have reported significant associations between exposure to \(PM_{2.5}\) and hospital admissions, but all have focused on the effects of short-term exposure. In addition all these studies have relied ...
    • Air conditioning and source-specific particles as modifiers of the effect of PM(10) on hospital admissions for heart and lung disease. 

      Janssen, Nicole A H; Schwartz, Joel David; Zanobetti, Antonella; Suh MacIntosh, Helen H. (National Institute of Environmental Health Sciences, 2002)
      Studies on acute effects of particulate matter (PM) air pollution show significant variability in exposure-effect relations among cities. Recent studies have shown an influence of ventilation on personal/indoor-outdoor ...
    • Air Pollution and ST-Segment Depression in Elderly Subjects 

      MacCallum, Gail; Canner, Marina J.; Gold, Diane R.; Litonjua, Augusto Ampil; Zanobetti, Antonella; Coull, Brent Andrew; Schwartz, Joel David; Verrier, Richard Leonard; Nearing, Bruce David; Suh MacIntosh, Helen H.; Stone, Peter Howard (National Institue of Environmental Health Sciences, 2005)
      Increased levels of daily ambient particle pollution have been associated with increased risk of cardiovascular morbidity. Black carbon (BC) is a measure of the traffic-related component of particles. We investigated ...
    • Air pollution attributable postneonatal infant mortality in U.S. metropolitan areas: a risk assessment study 

      Kaiser, Reinhard; Romieu, Isabelle; Medina, Sylvia; Schwartz, Joel David; Krzyzanowski, Michal; Künzli, Nino (BioMed Central, 2004)
      Background: The impact of outdoor air pollution on infant mortality has not been quantified. Methods: Based on exposure-response functions from a U.S. cohort study, we assessed the attributable risk of postneonatal infant ...
    • Air Pollution Exposure and Abnormal Glucose Tolerance during Pregnancy: The Project Viva Cohort 

      Fleisch, Abby F.; Gold, Diane R.; Rifas-Shiman, Sheryl L.; Koutrakis, Petros; Schwartz, Joel D.; Kloog, Itai; Melly, Steven; Coull, Brent A.; Zanobetti, Antonella; Gillman, Matthew W.; Oken, Emily (National Institute of Environmental Health Sciences, 2014)
      Background: Exposure to fine particulate matter (PM with diameter ≤ 2.5 μm; PM2.5) has been linked to type 2 diabetes mellitus, but associations with hyperglycemia in pregnancy have not been well studied. Methods: We studied ...
    • Air pollution exposure and gestational diabetes mellitus among pregnant women in Massachusetts: a cohort study 

      Fleisch, Abby F.; Kloog, Itai; Luttmann-Gibson, Heike; Gold, Diane R.; Oken, Emily; Schwartz, Joel D. (BioMed Central, 2016)
      Background: Rodent and human studies suggest an association between air pollution exposure and type 2 diabetes mellitus, but the extent to which air pollution is associated with gestational diabetes mellitus (GDM) is less ...
    • Air pollution exposure and lung function in highly exposed subjects in Beijing, China: a repeated-measure study 

      Baccarelli, Andrea A; Zheng, Yinan; Zhang, Xiao; Chang, Dou; Liu, Lei; Wolf, Katherine Rose; Zhang, Zhou; McCracken, John P; Díaz, Anaité; Bertazzi, Pier Alberto; Schwartz, Joel; Wang, Sheng; Kang, Choong-Min; Koutrakis, Petros; Hou, Lifang (BioMed Central, 2014)
      Background: Exposure to ambient particulate matter (PM) has been associated with reduced lung function. Elemental components of PM have been suggested to have critical roles in PM toxicity, but their contribution to ...
    • Air Pollution, Smoking, and Plasma Homocysteine 

      Baccarelli, Andrea; Zanobetti, Antonella; Martinelli, Ida; Grillo, Paolo; Hou, Lifang; Lanzani, Guido; Mannucci, Pier Mannuccio; Bertazzi, Pier Alberto; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2006)
      Background: Mild hyperhomocysteinemia is independently associated with an increased risk of cardiovascular disease. Air pollution exposure induces short-term inflammatory changes that may determine hyperhomocysteinemia, ...
    • Airborne Particulate Matter and Mitochondrial Damage: A Cross-Sectional Study 

      Hou, Lifang; Zhu, Zhong-Zheng; Nordio, Francesco; Bonzini, Matteo; Hoxha, Mirjam; Dioni, Laura; Marinelli, Barbara; Pegoraro, Valeria; Apostoli, Pietro; Bertazzi, Pier Alberto; Zhang, Xiao; Schwartz, Joel David; Baccarelli, Andrea (BioMed Central, 2010)
      Background: Oxidative stress generation is a primary mechanism mediating the effects of Particulate Matter (PM) on human health. Although mitochondria are both the major intracellular source and target of oxidative stress, ...
    • Alert Threshold Algorithms and Malaria Epidemic Detection 

      Teklehaimanot, Hailay Desta; Teklehaimanot, Awash; Schwartz, Joel David; Lipsitch, Marc (Centers for Disease Control and Prevention, 2004)
      We describe a method for comparing the ability of different alert threshold algorithms to detect malaria epidemics and use it with a dataset consisting of weekly malaria cases collected from health facilities in 10 districts ...
    • Alu and LINE-1 methylation and lung function in the normative ageing study 

      Lange, Nancy E; Sordillo, Joanne; Tarantini, Letizia; Bollati, Valentina; Sparrow, David; Vokonas, Pantel; Zanobetti, Antonella; Schwartz, Joel David; Baccarelli, Andrea; Litonjua, Augusto Ampil; Demeo, Dawn Lisa (BMJ Publishing Group, 2012)
      Objectives: To investigate the association between methylation of transposable elements Alu and long-interspersed nuclear elements (LINE-1) and lung function. Design: Cohort study. Setting: Outpatient Veterans Administration ...
    • Ambient air pollution, lung function, and airway responsiveness in asthmatic children 

      Ierodiakonou, Despo; Zanobetti, Antonella; Coull, Brent Andrew; Melly, Steven John; Postma, Dirkje S.; Boezen, H. Marike; Vonk, Judith M.; Williams, Paul V.; Shapiro, Gail G.; McKone, Edward F.; Hallstrand, Teal S.; Koenig, Jane Q.; Schildcrout, Jonathan S.; Lumley, Thomas; Fuhlbrigge, Anne Louise; Koutrakis, Petros; Schwartz, Joel David; Weiss, Scott Tillman; Gold, Diane R. (Elsevier BV, 2016)
      Background: Although ambient air pollution has been linked to reduced lung function in healthy children, longitudinal analyses of pollution effects in asthma are lacking. Objective: To investigate pollution effects in ...
    • Ambient and Microenvironmental Particles and Exhaled Nitric Oxide Before and After a Group Bus Trip 

      Adar, Sara Dubowsky; Adamkiewicz, Gary; Gold, Diane R.; Schwartz, Joel David; Coull, Brent Andrew; Suh MacIntosh, Helen H. (National Institute of Environmental Health Sciences, 2007)
      Objectives: Airborne particles have been linked to pulmonary oxidative stress and inflammation. Because these effects may be particularly great for traffic-related particles, we examined associations between particle ...
    • Ambient particulate matter and microRNAs in extracellular vesicles: a pilot study of older individuals 

      Rodosthenous, Rodosthenis S.; Coull, Brent A.; Lu, Quan; Vokonas, Pantel S.; Schwartz, Joel D.; Baccarelli, Andrea A. (BioMed Central, 2016)
      Background: Air pollution from particulate matter (PM) has been linked to cardiovascular morbidity and mortality; however the underlying biological mechanisms remain to be uncovered. Gene regulation by microRNAs (miRNAs) ...
    • Annual Ambient Black Carbon Associated with Shorter Telomeres in Elderly Men: Veterans Affairs Normative Aging Study 

      Hoxha, Mirjam; Dioni, Laura; McCracken, John Patrick; Baccarelli, Andrea; Melly, Steven John; Coull, Brent Andrew; Suh MacIntosh, Helen H.; Vokonas, Pantel S; Schwartz, Joel David (National Institute of Environmental Health Sciences, 2010)
      Background: Telomere length reflects biological age and is inversely associated with risk of cardiovascular disease (CVD). Ambient air pollution is associated with CVD, but its effect on telomere length is unknown. Objective: ...
    • Association between hemochromatosis genotype and lead exposure among elderly men: the normative aging study. 

      Wright, Robert O.; Silverman, Edwin Kepner; Schwartz, Joel David; Tsaih, Shring-Wern; Senter, Jody; Sparrow, David; Weiss, Scott Tillman; Aro, Antonio; Hu, Howard (2004)
      Because body iron burden is inversely associated with lead absorption, genes associated with hemochromatosis may modify body lead burden. Our objective was to determine whether the C282Y and/or H63D hemochromatosis gene ...
    • Association between leukocyte telomere shortening and exposure to traffic pollution: a cross-sectional study on traffic officers and indoor office workers 

      Hoxha, Mirjam; Dioni, Laura; Bonzini, Matteo; Pesatori, Angela Cecilia; Fustinoni, Silvia; Cavallo, Domenico; Carugno, Michele; Albetti, Benedetta; Marinelli, Barbara; Bertazzi, Pier Alberto; Schwartz, Joel David; Baccarelli, Andrea (BioMed Central, 2009)
      Background: Telomere shortening in blood leukocytes has been associated with increased morbidity and death from cardiovascular disease and cancer, but determinants of shortened telomeres, a molecular feature of biological ...
    • Association between Traffic-Related Black Carbon Exposure and Lung Function among Urban Women 

      Suglia, Shakira Franco; Gryparis, Alexandros; Schwartz, Joel David; Wright, Rosalind Jo (National Institute of Environmental Health Sciences, 2008)
      Background: Although a number of studies have documented the relationship between lung function and traffic-related pollution among children, few have focused on adult lung function or examined community-based populations. ...