Now showing items 1-5 of 5

• #### Expression-Guided in Silico Evaluation of Candidate Cis Regulatory Codes for Drosophila Muscle Founder Cells ﻿

(Public Library of Science, 2006)
While combinatorial models of transcriptional regulation can be inferred for metazoan systems from a priori biological knowledge, validation requires extensive and time-consuming experimental work. Thus, there is a need ...
• #### Inferring Condition-Specific Transcription Factor Function from DNA Binding and Gene Expression Data ﻿

(2007)
Numerous genomic and proteomic datasets are permitting the elucidation of transcriptional regulatory networks in the yeast Saccharomyces cerevisiae. However, predicting the condition dependence of regulatory network ...
• #### A Map of Human Genome Variation from Population Scale Sequencing ﻿

(Nature Publishing Group, 2010)
The 1000 Genomes Project aims to provide a deep characterization of human genome sequence variation as a foundation for investigating the relationship between genotype and phenotype. Here we present results of the pilot ...
• #### Mapping Copy Number Variation by Population Scale Genome Sequencing ﻿

(Nature Publishing Group, 2011)
Genomic structural variants (SVs) are abundant in humans, differing from other forms of variation in extent, origin and functional impact. Despite progress in SV characterization, the nucleotide resolution architecture of ...
• #### Predicting the Binding Preference of Transcription Factors to Individual DNA $\kappa$-mers ﻿

(Oxford University Press, 2008)
Motivation: Recognition of specific DNA sequences is a central mechanism by which transcription factors (TFs) control gene expression. Many TF-binding preferences, however, are unknown or poorly characterized, in part due ...