Browsing by Author "Brennan, Patrick"

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    • Regulatory iNKT cells lack PLZF expression and control Treg cell and macrophage homeostasis in adipose tissue 

      Lynch, Lydia; Michelet, Xavier; Zhang, Sai; Brennan, Patrick J.; Moseman, Ashley; Lester, Chantel; Besra, Gurdyal; Vomhof-Dekrey, Emilie E.; Tighe, Mike; Koay, Hui-Fern; Godfrey, Dale I.; Leadbetter, Elizabeth A.; Sant’Angelo, Derek B.; von Andrian, Ulrich; Brenner, Michael B. (2015)
      iNKT cells are CD1d-restricted lipid-sensing innate T cells that express the transcription factor PLZF. iNKT cells accumulate in adipose tissue, where they are anti-inflammatory, but the factors that contribute to their ...

    • Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells 

      Cohen, Nadia R.; Brennan, Patrick J.; Shay, Tal; Watts, Gerald F.; Brigl, Manfred; Kang, Joonsoo; Brenner, Michael B. (2013)
      Invariant natural killer T (iNKT) cells are innate-like T lymphocytes that act as critical regulators of the immune response. To better characterize this population, we profiled iNKT cell gene expression during ontogeny ...