Now showing items 1-8 of 8

    • Arthritis Imaging Using a Near-Infrared Fluorescence Folate-Targeted Probe 

      Chen, Wei-Tsung; Mahmood, Umar; Weissleder, Ralph; Tung, Ching-Hsuan (BioMed Central, 2005)
      A recently developed near-infrared fluorescence-labeled folate probe (NIR2-folate) was tested for in vivo imaging of arthritis using a lipopolysaccharide intra-articular injection model and a KRN transgenic mice serum ...
    • An EGFR Targeted PET Imaging Probe for the Detection of Colonic Adenocarcinomas in the Setting of Colitis 

      Turker, N. Selcan; Heidari, Pedram; Kucherlapati, Raju; Kucherlapati, Melanie; Mahmood, Umar (Ivyspring International Publisher, 2014)
      Colorectal cancer is a serious complication associated with inflammatory bowel disease, often indistinguishable by screening with conventional FDG PET probes. We have developed an alternative EGFR-targeted PET imaging probe ...
    • Genotype Directed Therapy in Murine Mismatch Repair Deficient Tumors 

      Kucherlapati, Melanie H.; Esfahani, Shadi; Habibollahi, Peiman; Wang, Junning; Still, Eric R.; Bronson, Roderick T.; Mahmood, Umar; Kucherlapati, Raju S. (Public Library of Science, 2013)
      The PI3K/AKT/mTOR pathway has frequently been found activated in human tumors. We show that in addition to Wnt signaling dysfunction, the PI3K/AKT/mTOR pathway is often upregulated in mouse Msh2−/− initiated intestinal ...
    • A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis 

      Zadra, Giorgia; Photopoulos, Cornelia; Tyekucheva, Svitlana; Heidari, Pedram; Weng, Qing Ping; Fedele, Giuseppe; Liu, Hong; Scaglia, Natalia; Priolo, Carmen; Sicinska, Ewa; Mahmood, Umar; Signoretti, Sabina; Birnberg, Neal; Loda, Massimo (Backwell Publishing Ltd, 2014)
      5′AMP-activated kinase (AMPK) constitutes a hub for cellular metabolic and growth control, thus representing an ideal therapeutic target for prostate cancers (PCas) characterized by increased lipogenesis and activation of ...
    • Optical Imaging of Mesenchymal Epithelial Transition Factor (MET) for Enhanced Detection and Characterization of Primary and Metastatic Hepatic Tumors 

      Esfahani, Shadi A.; Heidari, Pedram; Kim, Sun A.; Ogino, Shuji; Mahmood, Umar (Ivyspring International Publisher, 2016)
      Purpose: To assess optical imaging of Mesenchymal-Epithelial Transition factor (MET) for delineation and characterization of intrahepatic models of human hepatocellular carcinoma (HCC) and metastatic colorectal cancer ...
    • Optical Imaging with a Cathepsin B Activated Probe for the Enhanced Detection of Esophageal Adenocarcinoma by Dual Channel Fluorescent Upper GI Endoscopy 

      Habibollahi, Peiman; Figueiredo, Jose-Luiz; Heidari, Pedram; Dulak, Austin M; Imamura, Yu; Bass, Adam Joel; Ogino, Shuji; Chan, Andrew Tan; Mahmood, Umar (Ivyspring International Publisher, 2012)
      Despite significant advances in diagnosis and treatment, the prognosis of esophageal adenocarcinoma remains poor highlighting the importance of early detection. Although white light (WL) upper endoscopy can be used for ...
    • Systems-Level Modeling of Cancer-Fibroblast Interaction 

      Wadlow, Raymond C; Wittner, Ben; Finley, S. Aidan; Bergquist, Henry; Upadhyay, Rabi; Finn, Stephen; Loda, Massimo; Mahmood, Umar; Ramaswamy, Sridhar (Public Library of Science, 2009)
      Cancer cells interact with surrounding stromal fibroblasts during tumorigenesis, but the complex molecular rules that govern these interactions remain poorly understood thus hindering the development of therapeutic strategies ...
    • Targeted Nanoparticles for Imaging Incipient Pancreatic Ductal Adenocarcinoma 

      Kelly, Kimberly A.; Bardeesy, Nabeel; Anbazhagan, Rajesh; Gurumurthy, Sushma; Berger, Justin; Alencar, Herlen; DePinho, Ronald A.; Mahmood, Umar; Weissleder, Ralph (Public Library of Science, 2008)
      Background: Pancreatic ductal adenocarcinoma (PDAC) carries an extremely poor prognosis, typically presenting with metastasis at the time of diagnosis and exhibiting profound resistance to existing therapies. The development ...