Browsing by Author "Kelley, John"

Now showing items 1-11 of 11

    • Active Albuterol or Placebo, Sham Acupuncture, or No Intervention in Asthma 

      Wechsler, Michael E.; Kelley, John; Boyd, Ingrid O.E.; Dutile, Stefanie; Marigowda, Gautham; Kirsch, Irving; Israel, Elliot; Kaptchuk, Ted (Massachusetts Medical Society, 2011-07-14)
      BACKGROUND In prospective experimental studies in patients with asthma, it is difficult to determine whether responses to placebo differ from the natural course of physiological changes that occur without any intervention. ...

    • Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in Irritable Bowel Syndrome 

      Hall, Kathryn Tayo; Lembo, Anthony J.; Kirsch, Irving; Ziogas, Dimitrios C.; Douaiher, Jeffrey; Jensen, Karin; Conboy, Lisa Ann; Kelley, John Michael; Kokkotou, Efi G.; Kaptchuk, Ted Jack (Public Library of Science, 2012)
      Identifying patients who are potential placebo responders has major implications for clinical practice and trial design. Catechol-O-methyltransferase (COMT), an important enzyme in dopamine catabolism plays a key role in ...

    • Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome 

      Kaptchuk, Ted Jack; Kelley, John; Conboy, Lisa Ann; Kerr, Catherine; Davis, Roger B.; Jacobson, Eric Emil; Kirsch, Irving; Schyner, R. N; Nam, B. H.; Nguyen, L. T; Park, Min Hi; Rivers, A. L; McManus, C.; Kokkotou, Efi G.; Drossman, D. A; Goldman, Peter; Lembo, Anthony J. (BMJ, 2008)
      Objective To investigate whether placebo effects can experimentally be separated into the response to three components—assessment and observation, a therapeutic ritual (placebo treatment), and a supportive patient-practitioner ...

    • Conscientiousness is modified by genetic variation in catechol-O-methyltransferase to reduce symptom complaints in IBS patients 

      Hall, Kathryn T; Tolkin, Benjamin R; Chinn, Garrett M; Kirsch, Irving; Kelley, John M; Lembo, Anthony J; Kaptchuk, Ted J; Kokkotou, Efi; Davis, Roger B; Conboy, Lisa A (BlackWell Publishing Ltd, 2014)
      Background: Attention to and perception of physical sensations and somatic states can significantly influence reporting of complaints and symptoms in the context of clinical care and randomized trials. Although anxiety and ...

    • Effects of placebos without deception compared with no treatment: protocol for a systematic review and meta-analysis 

      Petkovic, Grace; Charlesworth, James E G; Kelley, John; Miller, Franklin; Roberts, Nia; Howick, Jeremy (BMJ Publishing Group, 2015)
      Introduction: Placebos have long provided a robust control for evaluating active pharmacological preparations, but frequently demonstrate a variable therapeutic effect when delivered in double-blinded placebo-controlled ...

    • The Influence of the Patient-Clinician Relationship on Healthcare Outcomes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials 

      Kelley, John M.; Kraft-Todd, Gordon; Schapira, Lidia; Kossowsky, Joe; Riess, Helen (Public Library of Science, 2014)
      Objective: To determine whether the patient-clinician relationship has a beneficial effect on either objective or validated subjective healthcare outcomes. Design: Systematic review and meta-analysis. Data Sources Electronic ...

    • “Maybe I Made Up the Whole Thing”: Placebos and Patients’ Experiences in a Randomized Controlled Trial 

      Kaptchuk, Ted Jack; Shaw, Jessica; Kerr, Catherine; Conboy, Lisa Ann; Kelley, John Michael; Csordas, Thomas J.; Lembo, Anthony J.; Jacobson, Eric Emil (Springer Verlag, 2009)
      Patients in the placebo arms of randomized controlled trials (RCT) often experience positive changes from baseline. While multiple theories concerning such “placebo effects” exist, peculiarly, none has been informed by ...

    • Patient and Practitioner Influences on the Placebo Effect in Irritable Bowel Syndrome 

      Kelley, John Michael; Lembo, Anthony J.; Ablon, John Stuart; Villanueva, Joel J.; Conboy, Lisa Ann; Levy, Raymond Arthur; Marci, Carl David; Kerr, Catherine; Kirsch, Irving; Jacobson, Eric Emil; Riess, Helen; Kaptchuk, Ted Jack (Ovid Technologies (Wolters Kluwer Health), 2009)
      Objective: To determine whether placebo responses can be explained by characteristics of the patient, the practitioner, or their interpersonal interaction. Methods: We performed an analysis of videotape and psychometric ...

    • Placebo acupuncture as a form of ritual touch healing: A neurophenomenological model 

      Kerr, Catherine; Shaw, Jessica R.; Conboy, Lisa Ann; Kelley, John Michael; Jacobson, Eric Emil; Kaptchuk, Ted Jack (Elsevier BV, 2011)
      Evidence that placebo acupuncture is an effective treatment for chronic pain presents a puzzle: how do placebo needles appearing to patients to penetrate the body, but instead sitting on the skin’s surface in the manner ...

    • Placebos without Deception: A Randomized Controlled Trial in Irritable Bowel Syndrome 

      Kaptchuk, Ted Jack; Friedlander, Elizabeth; Kelley, John Michael; Sanchez, M. Norma; Kokkotou, Efi G.; Singer, Joyce P.; Kowalczykowski, Magda; Miller, Franklin G.; Kirsch, Irving; Lembo, Anthony J. (Public Library of Science, 2010)
      Background: Placebo treatment can significantly influence subjective symptoms. However, it is widely believed that response to placebo requires concealment or deception. We tested whether open-label placebo (non-deceptive ...

    • A Treatment Trial of Acupuncture in IBS Patients 

      Lembo, Anthony J.; Conboy, Lisa Ann; Kelley, John Michael; Schnyer, Rosa S; McManus, Claire A; Quilty, Mary T; Kerr, Catherine; Drossman, Doug; Jacobson, Eric Emil; Davis, Roger B.; Kaptchuk, Ted Jack (Nature Publishing Group, 2009)
      Objective: To compare the effects of true and sham acupuncture in relieving symptoms of IBS. Methods: A total of 230 adult IBS patients (75% females, average age 38.4 yrs) were randomly assigned to 3 weeks of true or sham ...