Browsing by Author "Najafian, Nader"
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Cellular and molecular immune profiles in renal transplant recipients after conversion from Tacrolimus to Sirolimus
Gallon, Lorenzo; Traitanon, Opas; Sustento-Reodica, Nedjema; Leventhal, Joseph; Ansari, M. Javeed; Gehrau, Ricardo C.; Ariyamuthu, Venkatesh; De Serres, Sacha A; Alvarado, Antonio; Chhabra, Darshika; Mathew, James M; Najafian, Nader; Mas, Valeria (2014)Tacrolimus and Sirolimus are commonly used maintenance immunesuppressants in kidney transplantation. Since their effects on immune cells and allograft molecular profiles have not been elucidated, we characterized the effects ... -
Immunophenotyping and Efficacy of Low Dose ATG in Non-Sensitized Kidney Recipients Undergoing Early Steroid Withdrawal: A Randomized Pilot Study
Grafals, Monica; Smith, Brian; Murakami, Naoka; Trabucco, Agnes; Hamill, Katherine; Marangos, Erick; Gilligan, Hannah; Pomfret, Elizabeth A.; Pomposelli, James J.; Simpson, Mary A.; Azzi, Jamil; Najafian, Nader; Riella, Leonardo V. (Public Library of Science, 2014)Rabbit antithymocyte globulin (ATG) is commonly used as an induction therapy in renal transplant recipients, but the ideal dosage in tacrolimus-based early steroid withdrawal protocols has not been established. The purpose ... -
Prolonged, Low-Dose Anti-Thymocyte Globulin, Combined with CTLA4-Ig, Promotes Engraftment in a Stringent Transplant Model
D’Addio, Francesca; Boenisch, Olaf; Magee, Ciara N; Yeung, Melissa; Yuan, Xueli; Mfarrej, Bechara; Vergani, Andrea; Ansari, Mohammed Javeed; Fiorina, Paolo; Najafian, Nader (Public Library of Science, 2013)Background: Despite significant nephrotoxicity, calcineurin inhibitors (CNIs) remain the cornerstone of immunosuppression in solid organ transplantation. We, along with others, have reported tolerogenic properties of ... -
The Role of Coinhibitory Signaling Pathways in Transplantation and Tolerance
McGrath, Martina M.; Najafian, Nader (Frontiers Research Foundation, 2012)Negative costimulatory molecules, acting through so-called inhibitory pathways, play a crucial role in the control of T cell responses. This negative “second signal” opposes T cell receptor activation and leads to ...