Browsing by Author "Osaki, Hikari"

Now showing items 1-1 of 1

    • A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression 

      Giotopoulos, George; van der Weyden, Louise; Osaki, Hikari; Rust, Alistair G.; Gallipoli, Paolo; Meduri, Eshwar; Horton, Sarah J.; Chan, Wai-In; Foster, Donna; Prinjha, Rab K.; Pimanda, John E.; Tenen, Daniel G.; Vassiliou, George S.; Koschmieder, Steffen; Adams, David J.; Huntly, Brian J.P. (The Rockefeller University Press, 2015)
      The introduction of highly selective ABL-tyrosine kinase inhibitors (TKIs) has revolutionized therapy for chronic myeloid leukemia (CML). However, TKIs are only efficacious in the chronic phase of the disease and effective ...