Now showing items 1-8 of 8

    • A Bayesian Approach for Fast and Accurate Gene Tree Reconstruction 

      Rasmussen, Matthew D.; Kellis, Manolis (Oxford University Press, 2011)
      Recent sequencing and computing advances have enabled phylogenetic analyses to expand to both entire genomes and large clades, thus requiring more efficient and accurate methods designed specifically for the phylogenomic ...
    • The Changing Face of Genomics 

      Kellis, Manolis (BioMed Central, 2004)
      A report on the 5th annual Advances in Genome Biology and Technology (AGBT) and Automation in DNA Mapping and Sequencing (AMS) meeting, Marco Island, USA, 4-7 February 2004.
    • Common Variants at 9p21 and 8q22 Are Associated with Increased Susceptibility to Optic Nerve Degeneration in Glaucoma 

      Yaspan, Brian L.; Hauser, Michael A.; Allingham, R. Rand; Olson, Lana M.; Abdrabou, Wael; Brodeur, Wendy; Budenz, Donald L.; Caprioli, Joseph; Crenshaw, Andrew; Crooks, Kristy; DelBono, Elizabeth; Doheny, Kimberly F.; Gaasterland, Douglas; Gaasterland, Terry; Laurie, Cathy; Lichter, Paul R.; Loomis, Stephanie; Liu, Yutao; Medeiros, Felipe A.; McCarty, Cathy; Mirel, Daniel; Moroi, Sayoko E.; Musch, David C.; Realini, Anthony; Rozsa, Frank W.; Schuman, Joel S.; Scott, Kathleen; Singh, Kuldev; Trager, Edward H.; VanVeldhuisen, Paul; Vollrath, Douglas; Wollstein, Gadi; Yoneyama, Sachiko; Zhang, Kang; Weinreb, Robert N.; Ernst, Jason; Masuda, Tomohiro; Zack, Don; Richards, Julia E.; Pericak-Vance, Margaret; Haines, Jonathan L.; Wiggs, Janey Lee; Kang, Jae Hee Hee; Fan, Baojian; Wang, Danyi; Friedman, David S.; Lee, Richard K.; Stein, Joshua D.; Kellis, Manolis; Pasquale, Louis (Public Library of Science, 2012)
      Optic nerve degeneration caused by glaucoma is a leading cause of blindness worldwide. Patients affected by the normal-pressure form of glaucoma are more likely to harbor risk alleles for glaucoma-related optic nerve ...
    • A Comprehensive Map of Insulator Elements for the Drosophila Genome 

      Nègre, Nicolas; Kheradpour, Pouya; Morrison, Carolyn A.; Henikoff, Jorja G.; Feng, Xin; Ahmad, Kami; Stein, Lincoln; Henikoff, Steven; White, Kevin P.; Brown, Christopher D.; Shah, Parantu; Russell, Steven; White, Robert A. H.; Kellis, Manolis (Public Library of Science, 2010)
      Insulators are DNA sequences that control the interactions among genomic regulatory elements and act as chromatin boundaries. A thorough understanding of their location and function is necessary to address the complexities ...
    • High Depth, Whole-Genome Sequencing of Cholera Isolates from Haiti and the Dominican Republic 

      Sealfon, Rachel; Gire, Stephen; Ellis, Crystal Nicole; Calderwood, Stephen Beaven; Qadri, Firdausi; Hensley, Lisa; Kellis, Manolis; Ryan, Edward Thomas; Larocque, Regina Celes; Harris, Jason B.; Sabeti, Pardis Christine (BioMed Central, 2012)
      Background: Whole-genome sequencing is an important tool for understanding microbial evolution and identifying the emergence of functionally important variants over the course of epidemics. In October 2010, a severe cholera ...
    • Large-scale discovery and validation of functional elements in the human genome 

      Bernstein, Bradley E.; Kellis, Manolis (BioMed Central, 2005)
      A report on the genomics workshop 'Identification of Functional Elements in Mammalian Genomes', Cold Spring Harbor, New York, 11-13 November 2004.
    • Performance and Scalability of Discriminative Metrics for Comparative Gene Identification in 12 Drosophila Genomes 

      Deoras, Ameya N.; Rasmussen, Matthew D.; Guigó, Roderic; Lin, Michael; Kellis, Manolis (Public Library of Science, 2008)
      Comparative genomics of multiple related species is a powerful methodology for the discovery of functional genomic elements, and its power should increase with the number of species compared. Here, we use 12 Drosophila ...
    • Sequences to Systems 

      Kellis, Manolis; Rinn, John L (BioMed Central, 2010)
      A report of the seventh annual meeting on Systems Biology: Global Regulation of Gene Expression, 23-27 March 2010, Cold Spring Harbor, USA.