Browsing by Author "Kahle, Kristopher T."
Now showing items 1-14 of 14
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Bumetanide Enhances Phenobarbital Efficacy in a Rat Model of Hypoxic Neonatal Seizures
Cleary, Ryan T.; Sun, Hongyun; Huynh, Thanhthao; Manning, Simon; Li, Yijun; Rotenberg, Alexander; Talos, Delia M.; Kahle, Kristopher Thomas; Jackson, Michele; Rakhade, Sanjay N.; Berry, Gerard T.; Jensen, Frances Elizabeth (Public Library of Science, 2013)Neonatal seizures can be refractory to conventional anticonvulsants, and this may in part be due to a developmental increase in expression of the neuronal Na+-K+-2 Cl− cotransporter, NKCC1, and consequent paradoxical ... -
Cerebral edema and a transtentorial brain herniation syndrome associated with pandemic swine influenza A (H1N1) virus infection
Kahle, Kristopher; Walcott, Brian; Nahed, Brian Vala; Barnard, Zachary R.; Lo, Eng H.; Buonanno, Ferdinando Stelio; Venna, Nagagopal; Ning, MingMing (Elsevier BV, 2011)Acute encephalitis, encephalopathy, and seizures are known rare neurologic sequelae of respiratory tract infection with seasonal influenza A and B virus, but the neurological complications of the pandemic 2009 swine influenza ... -
Craniectomy for Malignant Cerebral Infarction: Prevalence and Outcomes in US Hospitals
Walcott, Brian; Kuklina, Elena V.; Nahed, Brian Vala; George, Mary G.; Kahle, Kristopher; Simard, J. Marc; Asaad, Wael F.; Coumans, Jean-Valery C E (Public Library of Science (PLoS), 2011)Object: Randomized trials have demonstrated the efficacy of craniectomy for the treatment of malignant cerebral edema following ischemic stroke. We sought to determine the prevalence and outcomes related to this by using ... -
Current view on the functional regulation of the neuronal K+-Cl− cotransporter KCC2
Medina, Igor; Friedel, Perrine; Rivera, Claudio; Kahle, Kristopher T.; Kourdougli, Nazim; Uvarov, Pavel; Pellegrino, Christophe (Frontiers Media S.A., 2014)In the mammalian central nervous system (CNS), the inhibitory strength of chloride (Cl−)-permeable GABAA and glycine receptors (GABAAR and GlyR) depends on the intracellular Cl− concentration ([Cl−]i). Lowering [Cl−]i ... -
Deep brain stimulation for medically refractory life-threatening status dystonicus in children
Walcott, Brian; Nahed, Brian Vala; Kahle, Kristopher; Duhaime, Ann-Christine; Sharma, Nutan; Eskandar, Emad (Journal of Neurosurgery Publishing Group (JNSPG), 2012)Generalized dystonic syndromes may escalate into persistent episodes of generalized dystonia known as status dystonicus that can be life-threatening due to dystonia-induced rhabdomyolysis and/or respiratory compromise. ... -
Glioblastoma Mimicking an Arteriovenous Malformation
Khanna, Arjun; Venteicher, Andrew S.; Walcott, Brian P.; Kahle, Kristopher T.; Mordes, Daniel A.; William, Christopher M.; Ghogawala, Zoher; Ogilvy, Christopher S. (Frontiers Media S.A., 2013)Abnormal cerebral vasculature can be a manifestation of a vascular malformation or a neoplastic process. We report the case of a patient with angiography-negative subarachnoid hemorrhage (SAH) who re-presented 3 years later ... -
Interfacility Helicopter Ambulance Transport of Neurosurgical Patients: Observations, Utilization, and Outcomes from a Quaternary Level Care Hospital
Walcott, Brian; Coumans, Jean-Valery C E; Mian, Matthew Kamal; Nahed, Brian Vala; Kahle, Kristopher (Public Library of Science (PLoS), 2011)Background: The clinical benefit of helicopter transport over ground transportation for interfacility transport is unproven. We sought to determine actual practice patterns, utilization, and outcomes of patients undergoing ... -
Limitations of Current GABA Agonists in Neonatal Seizures: Toward GABA Modulation Via the Targeting of Neuronal Cl− Transport
Khanna, Arjun; Walcott, Brian Patrick; Kahle, Kristopher T. (Frontiers Media S.A., 2013)Neonatal intensive care has advanced rapidly in the last 40 years, with dramatic decreases in mortality and morbidity; however, for neonatal seizures, neither therapies nor outcomes have changed significantly. Basic and ... -
Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizures
Puskarjov, Martin; Kahle, Kristopher T; Ruusuvuori, Eva; Kaila, Kai (BlackWell Publishing Ltd, 2014)Seizures are a common manifestation of acute neurologic insults in neonates and are often resistant to the standard antiepileptic drugs that are efficacious in children and adults. The paucity of evidence-based treatment ... -
Regulated phosphorylation of the K-Cl cotransporter KCC3 is a molecular switch of intracellular potassium content and cell volume homeostasis
Adragna, Norma C.; Ravilla, Nagendra B.; Lauf, Peter K.; Begum, Gulnaz; Khanna, Arjun R.; Sun, Dandan; Kahle, Kristopher T. (Frontiers Media S.A., 2015)The defense of cell volume against excessive shrinkage or swelling is a requirement for cell function and organismal survival. Cell swelling triggers a coordinated homeostatic response termed regulatory volume decrease ... -
Trends in inpatient setting laminectomy for excision of herniated intervertebral disc: Population-based estimates from the US nationwide inpatient sample
Walcott, Brian; Hanak, Brian W; Caracci, James R; Redjal, Navid; Nahed, Brian Vala; Kahle, Kristopher; Coumans, Jean-Valery C E (Medknow, 2011)Background: Herniated intervertebral discs can result in pain and neurological compromise. Treatment for this condition is categorized as surgical or non-surgical. We sought to identify trends in inpatient surgical management ... -
Trends in peptic ulcer disease and the identification of Helicobacter Pylori as a causative organism: Population-based estimates from the US nationwide inpatient sample
Walcott, Brian; Bashinskaya, Bronislava; Nahed, Brian Vala; Redjal, Navid; Kahle, Kristopher (Medknow, 2011)Background: Peptic ulcer disease can lead to serious complications including massive hemorrhage or bowel perforation. The modern treatment of peptic ulcer disease has transitioned from the control of gastric acid secretion ... -
Volumetric analysis of syringomyelia following hindbrain decompression for Chiari malformation Type I: syringomyelia resolution follows exponential kinetics
Coumans, Jean-Valery C E; Walcott, Brian; Butler, William Eugene; Nahed, Brian Vala; Kahle, Kristopher (Journal of Neurosurgery Publishing Group (JNSPG), 2011)Object: Resolution of syringomyelia is common following hindbrain decompression for Chiari malformation, yet little is known about the kinetics governing this process. The authors sought to establish the volumetric rate ... -
WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration
Zhu, Wen; Begum, Gulnaz; Pointer, Kelli; Clark, Paul A; Yang, Sung-Sen; Lin, Shih-Hua; Kahle, Kristopher T; Kuo, John S; Sun, Dandan (BioMed Central, 2014)Background: The bumetanide (BMT)-sensitive Na+-K+-2Cl- cotransporter isoform 1 (NKCC1) maintains cell volume homeostasis by increasing intracellular K+ and Cl- content via regulatory volume increase (RVI). Expression levels ...