Now showing items 1-20 of 20

    • Caveolin-1 Associated Adenovirus Entry into Human Corneal Cells 

      Yousuf, Mohammad A.; Zhou, Xiaohong; Mukherjee, Santanu; Chintakuntlawar, Ashish V.; Lee, Jeong Yoon; Ramke, Mirja; Chodosh, James; Rajaiya, Jaya (Public Library of Science, 2013)
      The cellular entry of viruses represents a critical area of study, not only for viral tropism, but also because viral entry dictates the nature of the immune response elicited upon infection. Epidemic keratoconjunctivitis ...
    • A comparison of retrokeratoprosthetic membrane and conjunctival inflammatory responses to silicone oil 

      Gilbert, Aubrey L; Jakobiec, Frederick A; Chodosh, James; Eliott, Dean (Springer, 2014)
      Silicone oil continues to be an important aid in retinal detachment surgery. We report a case in which disparate responses to silicone oil were noted in the conjunctiva and intraocularly. Intraocularly, the oil permeated ...
    • Computational and Serologic Analysis of Novel and Known Viruses in Species Human Adenovirus D in Which Serology and Genomics Do Not Correlate 

      Liu, Elizabeth B.; Wadford, Debra A.; Seto, Jason; Vu, Maria; Hudson, Nolan Ryan; Thrasher, Lisa; Torres, Sarah; Dyer, David W.; Seto, Donald; Jones, Morris S.; Chodosh, James (Public Library of Science, 2012)
      In November of 2007 a human adenovirus (HAdV) was isolated from a bronchoalveolar lavage (BAL) sample recovered from a biopsy of an AIDS patient who presented with fever, cough, tachycardia, and expiratory wheezes. To ...
    • Degeneration and Regeneration of Subbasal Corneal Nerves after Infectious Keratitis 

      Müller, Rodrigo T.; Abedi, Farshad; Cruzat, Andrea; Witkin, Deborah; Baniasadi, Neda; Cavalcanti, Bernardo M.; Jamali, Arsia; Chodosh, James; Dana, Reza; Pavan-Langston, Deborah; Hamrah, Pedram (Elsevier BV, 2015)
      Purpose To investigate the longitudinal alterations of subbasal corneal nerves in patients with infectious keratitis (IK) during acute phase, cessation of treatment and recovery phase by in vivo confocal microscopy ...
    • A Drug Delivery System for Administration of Anti–TNF-α Antibody 

      Robert, Marie-Claude; Frenette, Mathieu; Zhou, Chengxin; Yan, Yueran; Chodosh, James; Jakobiec, Frederick A.; Stagner, Anna M.; Vavvas, Demetrios; Dohlman, Claes H.; Paschalis, Eleftherios I. (The Association for Research in Vision and Ophthalmology, 2016)
      Purpose To describe the fabrication, evaluation, and preliminary in vivo safety of a new drug delivery system (DDS) for topical anti–TNF-α antibody administration. Methods: A DDS was fabricated using inverse template ...
    • Epidemic Keratoconjunctivitis-Causing Adenoviruses Induce MUC16 Ectodomain Release To Infect Ocular Surface Epithelial Cells 

      Menon, Balaraj B.; Zhou, Xiaohong; Spurr-Michaud, Sandra; Rajaiya, Jaya; Chodosh, James; Gipson, Ilene K. (American Society for Microbiology, 2016)
      ABSTRACT Human adenoviruses (HAdV), species D in particular (HAdV-D), are frequently associated with epidemic keratoconjunctivitis (EKC). Although the infection originates at the ocular surface epithelium, the mechanisms ...
    • Evidence of Molecular Evolution Driven by Recombination Events Influencing Tropism in a Novel Human Adenovirus that Causes Epidemic Keratoconjunctivitis 

      Walsh, Michael P.; Chintakuntlawar, Ashish; Harrach, Balázs; Hudson, Nolan R.; Schnurr, David; Heim, Albert; Seto, Donald; Jones, Morris S.; Robinson, Christopher; Madisch, Ijad; Chodosh, James (Public Library of Science, 2009)
      In 2005, a human adenovirus strain (formerly known as HAdV-D22/H8 but renamed here HAdV-D53) was isolated from an outbreak of epidemic keratoconjunctititis (EKC), a disease that is usually caused by HAdV-D8, -D19, or -D37, ...
    • Fatal Community-acquired Pneumonia in Children Caused by Re-emergent Human Adenovirus 7d Associated with Higher Severity of Illness and Fatality Rate 

      Yu, Zhiwu; Zeng, Zhiwei; Zhang, Jing; Pan, Yuxian; Chen, Manjun; Guo, Yonghui; Yu, Nan; Chodosh, James; Fu, Ning; Che, Xiaoyan; Zhang, Qiwei (Nature Publishing Group, 2016)
      Human adenoviruses (HAdVs) are highly contagious pathogens causing acute respiratory disease (ARD), such as community-acquired pneumonia. HAdV-7d, a re-emergent genomic variant, has been recently reported in Asia and the ...
    • Inflammation and the Nervous System: The Connection in the Cornea in Patients with Infectious Keratitis 

      Cruzat, Andrea; Witkin, Deborah; Baniasadi, Neda; Zheng, Lixin; Ciolino, Joseph B; Jurkunas, Ula V.; Chodosh, James; Pavan-Langston, Deborah; Dana, Reza; Hamrah, Pedram (Association for Research in Vision and Ophthalmology (ARVO), 2011)
      Purpose.: To investigate the ability of bevacizumab to penetrate the cornea after topical application or subconjunctival injection. Methods.: Bevacizumab 1% was topically applied three times a day to the corneas of mice ...
    • Inflammation and the Nervous System: The Connection in the Cornea in Patients with Infectious Keratitis 

      Cruzat, Andrea; Witkin, Deborah; Baniasadi, Neda; Zheng, Lixin; Ciolino, Joseph B; Jurkunas, Ula V.; Chodosh, James; Pavan-Langston, Deborah; Dana, Reza; Hamrah, Pedram (Association for Research in Vision and Ophthalmology (ARVO), 2011)
      Purpose. To study the density and morphologic characteristics of epithelial dendritic cells, as correlated to subbasal corneal nerve alterations in acute infectious keratitis (IK) by in vivo confocal microscopy ...
    • Molecular evolution of human adenoviruses 

      Robinson, Christopher; Singh, Gurdeep; Lee, Jeong Yoon; Dehghan, Shoaleh; Rajaiya, Jaya; Liu, Elizabeth B.; Yousuf, Mohammad Abu; Betensky, Rebecca Aubrey; Jones, Morris S.; Dyer, David W.; Seto, Donald; Chodosh, James (Nature Publishing Group, 2013)
      The recent emergence of highly virulent human adenoviruses (HAdVs) with new tissue tropisms underscores the need to determine their ontogeny. Here we report complete high quality genome sequences and analyses for all the ...
    • A Novel Implantable Glaucoma Valve Using Ferrofluid 

      Paschalis, Eleftherios I.; Chodosh, James; Sperling, Ralph A.; Salvador-Culla, Borja; Dohlman, Claes (Public Library of Science, 2013)
      Purpose To present a novel design of an implantable glaucoma valve based on ferrofluidic nanoparticles and to compare it with a well-established FDA approved valve. Setting: Massachusetts Eye & Ear Infirmary, Boston, USA. ...
    • Oral Acetazolamide after Boston Keratoprosthesis in Stevens Johnson Syndrome 

      Kumar, Radhika; Dohlman, Claes Henrik; Chodosh, James (BioMed Central, 2012)
      Background: Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare but severe and sometimes fatal condition associated with exposure to medications; sulfamethoxazole is among the most common causes. We ...
    • Predicting the Next Eye Pathogen: Analysis of a Novel Adenovirus 

      Robinson, Christopher; Zhou, Xiaohong; Rajaiya, Jayabarathy; Yousuf, Mohammad Abu; Singh, Gurdeep; DeSerres, Joshua J.; Walsh, Michael P.; Wong, Sallene; Seto, Donald; Dyer, David W.; Chodosh, James; Jones, Morris S. (American Society of Microbiology, 2013)
      For DNA viruses, genetic recombination, addition, and deletion represent important evolutionary mechanisms. Since these genetic alterations can lead to new, possibly severe pathogens, we applied a systems biology approach ...
    • Safety and Efficacy of the Multitargeted Receptor Kinase Inhibitor Pazopanib in the Treatment of Corneal Neovascularization 

      Amparo, Francisco; Sadrai, Zahra; Jin, Yiping; Alfonso-Bartolozzi, Belen; Wang, Haobing; Shikari, Hasanain; Ciolino, Joseph B; Chodosh, James; Jurkunas, Ula V.; Schaumberg, Debra Ann; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2013)
      Purpose. To evaluate the safety and efficacy of topical pazopanib in the treatment of corneal neovascularization (CNV). Methods. Twenty eyes of 20 patients with stable CNV were enrolled in a prospective, open ...
    • Specific NFκB Subunit Activation and Kinetics of Cytokine Induction in Adenoviral Keratitis 

      Rajaiya, Jayabarathy; Sadeghi, Neda; Chodosh, James (Molecular Vision, 2009)
      Purpose: Corneal inflammation associated with ocular adenoviral infection is caused by leukocytic infiltration of the subepithelial stroma in response to expression of interleukin-8 (IL-8) and monocyte chemoattractant ...
    • Titanium Coating of the Boston Keratoprosthesis 

      Salvador-Culla, Borja; Jeong, Kyung Jae; Kolovou, Paraskevi Evi; Chiang, Homer H.; Chodosh, James; Dohlman, Claes H.; Kohane, Daniel S. (The Association for Research in Vision and Ophthalmology, 2016)
      Purpose We tested the feasibility of using titanium to enhance adhesion of the Boston Keratoprosthesis (B-KPro), ultimately to decrease the risk of implant-associated complications. Methods: Cylindrical rods were made of ...
    • UBIAD1 Mutation Alters a Mitochondrial Prenyltransferase to Cause Schnyder Corneal Dystrophy 

      Nickerson, Michael L.; Kostiha, Brittany N.; Brandt, Wolfgang; Fredericks, William; Xu, Ke-Ping; Yu, Fu-Shin; Gold, Bert; Yamada, Masakazu; Tervo, Timo M.; Grutzmacher, Richard; Croasdale, Chris; Hoeltzenbein, Maria; Sutphin, John; Malkowicz, S. Bruce; Wessjohann, Ludger; Kruth, Howard S.; Dean, Michael; Weiss, Jayne S.; Chodosh, James; Goldberg, Marc; Lu, Da Wen (Public Library of Science, 2010)
      Background: Mutations in a novel gene, UBIAD1, were recently found to cause the autosomal dominant eye disease Schnyder corneal dystrophy (SCD). SCD is characterized by an abnormal deposition of cholesterol and phospholipids ...
    • Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren’s syndrome 

      Lessard, Christopher J.; Li, He; Adrianto, Indra; Ice, John A.; Rasmussen, Astrid; Grundahl, Kiely M.; Kelly, Jennifer A.; Dozmorov, Mikhail G.; Miceli-Richard, Corinne; Bowman, Simon; Lester, Sue; Eriksson, Per; Eloranta, Maija-Leena; Brun, Johan G.; Gøransson, Lasse G.; Harboe, Erna; Guthridge, Joel M.; Kaufman, Kenneth M.; Kvarnström, Marika; Jazebi, Helmi; Graham, Deborah S. Cunninghame; Grandits, Martha E.; Nazmul-Hossain, Abu N. M.; Patel, Ketan; Adler, Adam J.; Maier-Moore, Jacen S.; Farris, A. Darise; Brennan, Michael T.; Lessard, James A.; Chodosh, James; Gopalakrishnan, Rajaram; Hefner, Kimberly S.; Houston, Glen D.; Huang, Andrew J.W.; Hughes, Pamela J.; Lewis, David M.; Radfar, Lida; Rohrer, Michael D.; Stone, Donald U.; Wren, Jonathan D.; Vyse, Timothy J.; Gaffney, Patrick M.; James, Judith A.; Omdal, Roald; Wahren-Herlenius, Marie; Illei, Gabor G.; Witte, Torsten; Jonsson, Roland; Rischmueller, Maureen; Rönnblom, Lars; Nordmark, Gunnel; Ng, Wan-Fai; Mariette, Xavier; Anaya, Juan-Manuel; Rhodus, Nelson L.; Segal, Barbara M.; Scofield, R. Hal; Montgomery, Courtney G.; Harley, John B.; Sivils, Kathy L. Moser (2013)
      Sjögren’s syndrome is a common autoimmune disease (~0.7% of European Americans) typically presenting as keratoconjunctivitis sicca and xerostomia. In addition to strong association within the HLA region at 6p21 ...
    • Viral Capsid Is a Pathogen-Associated Molecular Pattern in Adenovirus Keratitis 

      Chintakuntlawar, Ashish V.; Zhou, Xiaohong; Rajaiya, Jayabarathy; Chodosh, James (Public Library of Science, 2010)
      Human adenovirus (HAdV) infection of the human eye, in particular serotypes 8, 19 and 37, induces the formation of corneal subepithelial leukocytic infiltrates. Using a unique mouse model of adenovirus keratitis, we studied ...