Now showing items 1-13 of 13

    • A 44-year-old man with eye, kidney, and brain dysfunction 

      Vodopivec, Ivana; Oakley, Derek Hayden; Perugino, Cory Adam; Venna, Nagagopal; Hedley-Whyte, E. Tessa; Stone, John H (Wiley-Blackwell, 2016)
      Retinal vasculopathy with cerebral leukodystrophy (RVCL) is a rare, autosomal dominant condition caused by mutations of the three-prime repair exonuclease-1 (TREX1). The phenotypic expressions range from isolated retinal ...
    • Chronic Sclerosing Sialadenitis (Küttner Tumor) Is an IgG4-associated Disease 

      Geyer, Julia Turbiner; Ferry, Judith Ann; Harris, Nancy Lee; Stone, John H; Zukerberg, Lawrence R.; Lauwers, Gregory Y.; Pilch, Ben Z.; Deshpande, Vikram (Ovid Technologies (Wolters Kluwer Health), 2010)
      BACKGROUND: Chronic sclerosing sialadenitis is a fibroinflammatory disease of the salivary glands, characteristically of the submandibular gland. One prior Asian study proposed that chronic sclerosing sialadenitis is a ...
    • Consensus Statement on the Pathology of IgG4-Related Disease 

      Deshpande, Vikram; Zen, Yoh; Chan, John KC; Yi, Eunhee E; Sato, Yasuharu; Yoshino, Tadashi; Klöppel, Günter; Heathcote, J Godfrey; Khosroshahi, Arezou; Ferry, Judith Ann; Aalberse, Rob C; Bloch, Donald Bendit; Brugge, William Robert; Bateman, Adrian C; Carruthers, Mollie Nicole; Chari, Suresh T; Cheuk, Wah; Cornell, Lynn D; Fernandez-Del Castillo, Carlos F.; Forcione, David G.; Hamilos, Daniel L.; Kamisawa, Terumi; Kasashima, Satomi; Kawa, Shigeyuki; Kawano, Mitsuhiro; Lauwers, Gregory Y.; Masaki, Yasufumi; Nakanuma, Yasuni; Notohara, Kenji; Okazaki, Kazuichi; Ryu, Ji Kon; Saeki, Takako; Sahani, Dushyant V.; Smyrk, Thomas C; Stone, James Robert; Takahira, Masayuki; Webster, George J; Yamamoto, Motohisa; Zamboni, Giuseppe; Umehara, Hisanori; Stone, John H (Nature Publishing Group, 2012)
      IgG4-related disease is a newly recognized fibro-inflammatory condition characterized by several features: a tendency to form tumefactive lesions in multiple sites; a characteristic histopathological appearance; and—often ...
    • Design of the Tocilizumab in Giant Cell Arteritis Trial 

      Unizony, Sebastian; Dasgupta, Bhaskar; Fisheleva, Elena; Rowell, Lucy; Schett, Georg; Spiera, Robert; Zwerina, Jochen; Harari, Olivier; Stone, John H (Hindawi Publishing Corporation, 2013)
      Overview. The GiACTA trial is a multicenter, randomized, double-blind, and placebo-controlled study designed to test the ability of tocilizumab (TCZ), an interleukin (IL)-6 receptor antagonist, to maintain disease remission ...
    • Development and Implementation of a Double-Blind Corticosteroid-Tapering Regimen for a Clinical Trial 

      Collinson, Neil; Tuckwell, Katie; Habeck, Frank; Chapman, Monique; Klearman, Micki; Stone, John H. (Hindawi Publishing Corporation, 2015)
      We describe the design and operationalization of a blinded corticosteroid-tapering regimen for a randomized trial of tocilizumab in giant cell arteritis (GCA). To our knowledge, no clinical trial in any disease has ever ...
    • Development of an IgG4-RD Responder Index 

      Carruthers, Mollie Nicole; Stone, John H.; Deshpande, Vikram; Khosroshahi, Arezou (Hindawi Publishing Corporation, 2012)
      IgG4-related disease (IgG4-RD) is a multiorgan inflammatory disease in which diverse organ manifestations are linked by common histopathological and immunohistochemical features. Prospective studies of IgG4-RD patients are ...
    • Does Autoimmune Pancreatitis Increase the Risk of Pancreatic Carcinoma? 

      Gupta, Rajib; Khosroshahi, Arezou; Shinagare, Shweta; Fernandez, Carlos; Ferrone, Cristina Rosa; Lauwers, Gregory Y.; Stone, John H; Deshpande, Vikram (Ovid Technologies (Wolters Kluwer Health), 2013)
      OBJECTIVES: To estimate the risk of malignancy in autoimmune pancreatitis (AIP). METHODS: We examined resected pancreata to compare the prevalence of pancreatic intraepithelial neoplasia (PanIN) in 28 cases of AIP and ...
    • IgG4-Related Disease and Hypertrophic Pachymeningitis 

      Wallace, Zachary S.; Carruthers, Mollie N.; Khosroshahi, Arezou; Carruthers, Robert; Shinagare, Shweta; Stemmer-Rachamimov, Anat; Deshpande, Vikram; Stone, John H. (Wolters Kluwer Health, 2013)
      Abstract Hypertrophic pachymeningitis (HP) is an inflammatory condition in which the dura mater of the cranium or spine becomes thickened, leading to symptoms that result from mass effect, nerve compression, or vascular ...
    • IgG4-Related Disease Is Not Associated with Antibody to the Phospholipase A2 Receptor 

      Khosroshahi, Arezou; Ayalon, Rivka; Beck, Laurence H.; Salant, David J.; Bloch, Donald Bendit; Stone, John H. (Hindawi Publishing Corporation, 2012)
      Patients with IgG4-related disease (IgG4-RD) share histopathological characteristics that are similar across affected organs. The finding of infiltration with IgG4+ plasma cells in the proper clinical and histopathological ...
    • Rethinking Ormond’s Disease: “Idiopathic” Retroperitoneal Fibrosis in the Era of IgG4-Related Disease 

      Khosroshahi, Arezou; Carruthers, Mollie N.; Stone, John H.; Shinagare, Shweta; Sainani, Nisha; Hasserjian, Robert P.; Deshpande, Vikram (Wolters Kluwer Health, 2013)
      Abstract Idiopathic retroperitoneal fibrosis (RPF) is a periaortic sclerotic disease that encases adjacent retroperitoneal structures, particularly the ureters. A subset of idiopathic RPF cases can be associated with ...
    • Subclassification of Autoimmune Pancreatitis: A Histologic Classification With Clinical Significance 

      Deshpande, Vikram; Gupta, Rajib; Sainani, Nisha I.; Sahani, Dushyant V.; Virk, Renu; Ferrone, Cristina Rosa; Khosroshahi, Arezou; Stone, John H; Lauwers, Gregory Y. (Ovid Technologies (Wolters Kluwer Health), 2011)
      Autoimmune pancreatitis (AIP) is a chronic inflammatory disease of the pancreas. Examination of pancreatic resection specimens from patients with AIP has shown that there are 2 subclasses of this disease. However, there ...
    • Therapeutic approach to IgG4-related disease: A systematic review 

      Brito-Zerón, Pilar; Kostov, Belchin; Bosch, Xavier; Acar-Denizli, Nihan; Ramos-Casals, Manuel; Stone, John H. (Wolters Kluwer Health, 2016)
      Abstract To review the reported evidence on the therapeutic management of IgG4-related disease (IgG4-RD) in clinical practice. A systematic search of the literature was conducted. The primary outcome measured was the rate ...
    • Tissue IgG4-Positive Plasma Cells in Inflammatory Bowel Disease: A Study of 88 Treatment-Naive Biopsies of Inflammatory Bowel Disease 

      Virk, Renu; Shinagare, Shweta; Lauwers, Gregory Y.; Yajnik, Vijay; Stone, John H; Deshpande, Vikram (Nature Publishing Group, 2014)
      The distinction of Crohn's disease from ulcerative colitis is based on clinical, endoscopic, radiological, and histological findings, a paradigm that remains unchanged despite the advent of new understanding of the ...