Now showing items 1-4 of 4

    • Context influences on TALE–DNA binding revealed by quantitative profiling 

      Rogers, Julia M.; Barrera, Luis A.; Reyon, Deepak; Sander, Jeffry D.; Kellis, Manolis; Joung, J Keith; Bulyk, Martha L. (Nature Pub. Group, 2015)
      Transcription activator-like effector (TALE) proteins recognize DNA using a seemingly simple DNA-binding code, which makes them attractive for use in genome engineering technologies that require precise targeting. Although ...
    • EpiFire: An Open Source C++ Library and Application for Contact Network Epidemiology 

      Hladish, Thomas; Melamud, Eugene; Barrera, Luis Alberto; Galvani, Alison; Meyers, Lauren Ancel (BioMed Central, 2012)
      Background: Contact network models have become increasingly common in epidemiology, but we lack a flexible programming framework for the generation and analysis of epidemiological contact networks and for the simulation ...
    • Highly parallel assays of tissue-specific enhancers in whole Drosophila embryos 

      Gisselbrecht, Stephen S.; Barrera, Luis A.; Porsch, Martin; Aboukhalil, Anton; Estep, Preston W.; Vedenko, Anastasia; Palagi, Alexandre; Kim, Yongsok; Zhu, Xianmin; Busser, Brian W.; Gamble, Caitlin E.; Iagovitina, Antonina; Singhania, Aditi; Michelson, Alan M.; Bulyk, Martha L. (2013)
      Transcriptional enhancers are a primary mechanism by which tissue-specific gene expression is achieved. Despite the importance of these regulatory elements in development, responses to environmental stresses, and disease, ...
    • Towards a Systematic Approach for Characterizing Regulatory Variation 

      Barrera, Luis A. (2015-11-03)
      A growing body of evidence suggests that genetic variants that alter gene expression are responsible for many phenotypic differences across individuals, particularly for the risk of developing common diseases. However, the ...