Now showing items 1-3 of 3

    • The Epithelial-Mesenchymal Transition Factor SNAIL Paradoxically Enhances Reprogramming 

      Unternaehrer, Juli J.; Zhao, Rui; Kim, Kitai; Cesana, Marcella; Powers, John T.; Ratanasirintrawoot, Sutheera; Onder, Tamer; Shibue, Tsukasa; Weinberg, Robert A.; Daley, George Q. (Elsevier, 2014)
      Summary Reprogramming of fibroblasts to induced pluripotent stem cells (iPSCs) entails a mesenchymal to epithelial transition (MET). While attempting to dissect the mechanism of MET during reprogramming, we observed that ...
    • Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma 

      Powers, John T; Tsanov, Kaloyan M; Pearson, Daniel S; Roels, Frederik; Spina, Catherine S; Ebright, Richard; Seligson, Marc; de Soysa, Yvanka; Cahan, Patrick; Theiβen, Jessica; Tu, Ho-Chou; Han, Areum; Kurek, Kyle C; LaPier, Grace S; Osborne, Jihan K; Ross, Samantha J; Cesana, Marcella; Collins, James J; Berthold, Frank; Daley, George Q (2016)
      Poor prognosis in neuroblastoma is associated with genetic amplification of MYCN. MYCN is itself a target of let-7, a tumor suppressor family of microRNAs implicated in numerous cancers. LIN28B, an inhibitor of let-7 ...
    • Transcriptional and Chromatin Dynamics of Muscle Regeneration after Severe Trauma 

      Aguilar, Carlos A.; Pop, Ramona; Shcherbina, Anna; Watts, Alain; Matheny, Ronald W.; Cacchiarelli, Davide; Han, Woojin M.; Shin, Eunjung; Nakhai, Shadi A.; Jang, Young C.; Carrigan, Christopher T.; Gifford, Casey A.; Kottke, Melissa A.; Cesana, Marcella; Lee, Jackson; Urso, Maria L.; Meissner, Alexander (Elsevier, 2016)
      Summary Following injury, adult skeletal muscle undergoes a well-coordinated sequence of molecular and physiological events to promote repair and regeneration. However, a thorough understanding of the in vivo epigenomic ...