Now showing items 1-6 of 6

    • AKAP9 regulates activation-induced retention of T lymphocytes at sites of inflammation 

      Herter, Jan M.; Grabie, Nir; Cullere, Xavier; Azcutia, Veronica; Rosetti, Florencia; Bennett, Paul; Herter-Sprie, Grit S.; Elyaman, Wassim; Luscinskas, Francis W.; Lichtman, Andrew H.; Mayadas, Tanya N. (Nature Publishing Group, 2015)
      The mechanisms driving T cell homing to lymph nodes and migration to tissue are well described but little is known about factors that affect T cell egress from tissues. Here, we generate mice with a T cell-specific deletion ...
    • ICER is requisite for Th17 differentiation 

      Yoshida, Nobuya; Comte, Denis; Mizui, Masayuki; Otomo, Kotaro; Rosetti, Florencia; Mayadas, Tanya N.; Crispín, José C.; Bradley, Sean J.; Koga, Tomohiro; Kono, Michihito; Karampetsou, Maria P.; Kyttaris, Vasileios C.; Tenbrock, Klaus; Tsokos, George C. (Nature Publishing Group, 2016)
      Inducible cAMP early repressor (ICER) has been described as a transcriptional repressor isoform of the cAMP response element modulator (CREM). Here we report that ICER is predominantly expressed in Th17 cells through the ...
    • Lactoferrin Suppresses Neutrophil Extracellular Traps Release in Inflammation 

      Okubo, Koshu; Kamiya, Mako; Urano, Yasuteru; Nishi, Hiroshi; Herter, Jan M.; Mayadas, Tanya; Hirohama, Daigoro; Suzuki, Kazuo; Kawakami, Hiroshi; Tanaka, Mototsugu; Kurosawa, Miho; Kagaya, Shinji; Hishikawa, Keiichi; Nangaku, Masaomi; Fujita, Toshiro; Hayashi, Matsuhiko; Hirahashi, Junichi (Elsevier, 2016)
      Neutrophils are central players in the innate immune system. They generate neutrophil extracellular traps (NETs), which protect against invading pathogens but are also associated with the development of autoimmune and/or ...
    • Neutrophil extracellular traps in thrombosis and inflammation 

      Martinod, Kim Lindsay (2014-10-21)
      Neutrophil extracellular traps (NETs), chromatin released by activated neutrophils, were first described for their antimicrobial properties. NETs have a backbone of DNA and histones lined with microbicidal proteins such ...
    • Neutrophil human Fcg Receptor IIA and the b2 integrin Mac-1 cross-talk in autoimmune disease 

      Rosetti Sciutto, Florencia (2014-06-06)
      Systemic lupus erythematosus (SLE) is a chronic multiorgan autoimmune disorder characterized by abundant immune complex (IC) deposition, with nephritis being a major cause of morbidity and mortality. Yet, IC deposition ...
    • Protection from septic peritonitis by rapid neutrophil recruitment through omental high endothelial venules 

      Buscher, Konrad; Wang, Huiyu; Zhang, Xueli; Striewski, Paul; Wirth, Benedikt; Saggu, Gurpanna; Lütke-Enking, Stefan; Mayadas, Tanya N.; Ley, Klaus; Sorokin, Lydia; Song, Jian (Nature Publishing Group, 2016)
      Acute peritonitis is a frequent medical condition that can trigger severe sepsis as a life-threatening complication. Neutrophils are first-responders in infection but recruitment mechanisms to the abdominal cavity remain ...