Now showing items 1-10 of 10

    • Association between Virus-Specific T-Cell Responses and Plasma Viral Load in Human Immunodeficiency Virus Type 1 Subtype C Infection 

      Novitsky, Vladimir A.; Gilbert, P.; Peter, T.; McLane, Mary Frances; Gaolekwe, S.; Rybak, N.; Thior, Ibou; Ndung, T.; Marlink, Richard G.; Lee, Tae Ho; Essex, Myron Elmer (American Society for Microbiology, 2003)
      Virus-specific T-cell immune responses are important in restraint of human immunodeficiency virus type 1 (HIV-1) replication and control of disease. Plasma viral load is a key determinant of disease progression and ...
    • Effect of Micronutrient Supplementation on Disease Progression in Asymptomatic, Antiretroviral-Naive, HIV-Infected Adults in Botswana 

      Baum, Marianna K.; Campa, Adriana; Lai, Shenghan; Sales Martinez, Sabrina; Tsalaile, Lesedi; Burns, Patricia Jeanne; Farahani, Mansour Safaie; Li, Yinghui; van Widenfelt, Erik; Page, John Bryan; Bussmann, Hermann; Fawzi, Wafaie W.; Moyo, Sikhulele; Makhema, Joseph Moeketsi; Thior, Ibou; Essex, Myron Elmer; Marlink, Richard G. (American Medical Association (AMA), 2013)
      IMPORTANCE Micronutrient deficiencies occur early in human immunodeficiency virus (HIV) infection, and supplementation with micronutrients may be beneficial; however, its effectiveness has not been investigated early ...
    • Evaluation of the False Recent Classification Rates of Multiassay Algorithms in Estimating HIV Type 1 Subtype C Incidence 

      Moyo, Sikhulile; LeCuyer, Tessa; Wang, Rui; Gaseitsiwe, Simani; Weng, Jia; Musonda, Rosemary Mubanga; Bussmann, Hermann; Mine, Madisa; Engelbrecht, Susan; Makhema, Joseph Moeketsi; Marlink, Richard G.; Baum, Marianna K.; Novitsky, Vladimir A.; Essex, Myron Elmer (Mary Ann Liebert Inc, 2014)
      Laboratory cross-sectional assays are useful for the estimation of HIV incidence, but are known to misclassify individuals with long-standing infection as recently infected. The false recent rate (FRR) varies widely across ...
    • Gender-sensitive reporting in medical research 

      Heidari, Shirin; Abdool Karim, Quarraisha; Auerbach, Judith D.; Buitendijk, Simone E.; Cahn, Pedro; Curno, Mirjam J.; Hankins, Catherine; Katabira, Elly; Kippax, Susan; Marlink, Richard George; Marsh, Joan; Marusic, Ana; Nass, Heidi M.; Montaner, Julio; Pollitzer, Elizabeth; Ruiz-Cantero, Maria Teresa; Sherr, Lorraine; Sow, Papa Salif; Squires, Kathleen; Wainberg, Mark A. (BioMed Central, 2012)
      Sex and gender differences influence the health and wellbeing of men and women. Although studies have drawn attention to observed differences between women and men across diseases, remarkably little research has been ...
    • HIV-1 Subtype C-Infected Individuals Maintaining High Viral Load as Potential Targets for the “Test-and-Treat” Approach to Reduce HIV Transmission 

      Baum, Marianna; Thior, Ibou; Asmelash, Aida; Campa, Adriana; van Widenfelt, Erik; Mine, Madisa; Moffat, Claire; Mmalane, Mompati; Gilbert, Peter; Novitsky, Vladimir A.; Wang, Rui; Bussmann, Hermann; Lockman, Shahin; Shapiro, Roger L.; Wester, Carolyn Negley; Wester, C William; Ogwu, Anthony; Musonda, Rosemary Mubanga; Moyo, Sikhulile; Makhema, Joseph Moeketsi; Marlink, Richard George; Seage, George R.; De Gruttola, Victor Gerard; Essex, Myron Elmer (Public Library of Science, 2010)
      The first aim of the study is to assess the distribution of HIV-1 RNA levels in subtype C infection. Among 4,348 drug-naïve HIV-positive individuals participating in clinical studies in Botswana, the median baseline plasma ...
    • Immunohaematological reference values for HIV-negative healthy adults in Botswana 

      Mine, Madisa; Moyo, Sikhulile; Stevens, Penny; Michael, Kurt; Novitsky, Vladimir A.; Makhaola, Kgomotso; Asmelash, Aida; Molefhabangwe, S’khatele; Woldegabriel, Elias; Mothowaeng, Gaseboloke; Maruta, Talkmore; Kamhukamwe, Charity; Mangwendeza, Phibeon M.; Holmes-Pretorius, Molly; Mtoni, Isaac; Motswaledi, Modisa; Musonda, Rosemary Mubanga; Ndwapi, Ndwapi; Makhema, Joseph Moeketsi; Marlink, Richard G.; Seipone, Khumo; Gaolathe, Tendani; Essex, Myron Elmer (AOSIS, 2011)
      BACKGROUND: Clinical laboratories in Botswana have relied entirely on the reference intervals for normal immunohaematological values provided by manufacturers' kits and textbooks. OBJECTIVES: The aim of this study was to ...
    • Magnitude and Frequency of Cytotoxic T-Lymphocyte Responses: Identification of Immunodominant Regions of Human Immunodeficiency Virus Type 1 Subtype C 

      Novitsky, Vladimir A.; Cao, H.; Rybak, N.; Gilbert, P.; McLane, Mary Frances; Gaolekwe, S.; Peter, T.; Thior, I.; Ndung, T.; Marlink, Richard G.; Lee, Tae Ho; Essex, Myron Elmer (American Society for Microbiology, 2002)
      A systematic analysis of immune responses on a population level is critical for a human immunodeficiency virus type 1 (HIV-1) vaccine design. Our studies in Botswana on (i) molecular analysis of the HIV-1 subtype C (HIV-1C) ...
    • Molecular characterisation of hepatitis B virus in HIV-1 subtype C infected patients in Botswana 

      Anderson, Motswedi; Gaseitsiwe, Simani; Moyo, Sikhulile; Wessels, Matthijs J. C.; Mohammed, Terence; Sebunya, Theresa K.; Powell, Eleanor A.; Makhema, Joseph; Blackard, Jason T.; Marlink, Richard; Essex, Max; Musonda, Rosemary M. (BioMed Central, 2015)
      Background: Hepatitis B virus (HBV) is a major global health problem especially in sub-Saharan Africa and in East Asia. Ten hepatitis B virus genotypes have been described that differ by geographic distribution, disease ...
    • Risk Factors for Symptomatic Hyperlactatemia and Lactic Acidosis Among Combination Antiretroviral Therapy-Treated Adults in Botswana: Results from a Clinical Trial 

      Wester, C William; Eden, Svetlana K.; Shepherd, Bryan E.; Bussmann, Hermann; Novitsky, Vladimir A.; Samuels, David C.; Hendrickson, Sher L.; Winkler, Cheryl A.; O, Stephen J.; Essex, Myron Elmer; D, Richard T.; De Gruttola, Victor Gerard; Marlink, Richard G. (Mary Ann Liebert Inc., 2012)
      Nucleoside analogue reverse transcriptase inhibitors are an integral component of combination antiretroviral treatment regimens. However, their ability to inhibit polymerase-γ has been associated with several mitochondrial ...
    • Slow CD4+ T-Cell Recovery in Human Immunodeficiency Virus/Hepatitis B Virus-Coinfected Patients Initiating Truvada-Based Combination Antiretroviral Therapy in Botswana 

      Anderson, Motswedi; Gaseitsiwe, Simani; Moyo, Sikhulile; Thami, Kerapetse P.; Mohammed, Terence; Setlhare, Ditiro; Sebunya, Theresa K.; Powell, Eleanor A.; Makhema, Joseph; Blackard, Jason T.; Marlink, Richard; Essex, Max; Musonda, Rosemary M. (Oxford University Press, 2016)
      Background. Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) coinfection has emerged as an important cause of morbidity and mortality. We determined the response to Truvada-based first-line combination ...