Browsing by Author "Crum, Christopher"

Now showing items 1-7 of 7

    • Activated networking of platelet activating factor receptor and FAK/STAT1 induces malignant potential in BRCA1-mutant at-risk ovarian epithelium 

      Zhang, Lifang; Wang, Dan; Jiang, Wei; Edwards, Dale; Qiu, Weiliang; Barroilhet, Lisa M; Rho, Jung-hyun; Jin, Lianjin; Seethappan, Vanitha; Vitonis, Allison; Wang, Jianliu; Mok, Samuel C; Crum, Christopher Paul; Cramer, Daniel William; Ye, Bin (Springer Science + Business Media, 2010)
      Objectives It is essential to understand the molecular basis of ovarian cancer etiology and tumor development to provide more effective preventive and therapeutic approaches to reduce mortality. Particularly, the molecular ...

    • CA125 Immune Complexes in Ovarian Cancer Patients with Low CA125 Concentrations 

      Cramer, Daniel William; O'Rourke, D. J.; Vitonis, A. F.; Matulonis, Ursula Anne; DiJohnson, D. A.; Sluss, Patrick M.; Crum, Christopher Paul; Liu, B. C.- S. (American Association for Clinical Chemistry (AACC), 2010)
      BACKGROUND About 20% of women with ovarian cancer have low concentrations of serum cancer antigen 125 (CA125), and this important tumor marker cannot be used to monitor their disease. The measured concentration for mucin ...

    • Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours 

      Ince, Tan A.; Sousa, Aurea D.; Jones, Michelle A.; Harrell, J. Chuck; Agoston, Elin S.; Krohn, Marit; Selfors, Laura M.; Liu, Wenbin; Chen, Ken; Yong, Mao; Buchwald, Peter; Wang, Bin; Hale, Katherine S.; Cohick, Evan; Sergent, Petra; Witt, Abigail; Kozhekbaeva, Zhanna; Gao, Sizhen; Agoston, Agoston T.; Merritt, Melissa A.; Foster, Rosemary; Rueda, Bo R.; Crum, Christopher P.; Brugge, Joan S.; Mills, Gordon B. (Nature Pub. Group, 2015)
      Currently available human tumour cell line panels consist of a small number of lines in each lineage that generally fail to retain the phenotype of the original patient tumour. Here we develop a cell culture medium that ...

    • Gene Expression Signature of Normal Cell-of-Origin Predicts Ovarian Tumor Outcomes 

      Merritt, Melissa A.; Bentink, Stefan; Schwede, Matthew; Iwanicki, Marcin P.; Quackenbush, John; Woo, Terri; Agoston, Elin S.; Reinhardt, Ferenc; Crum, Christopher P.; Berkowitz, Ross S.; Mok, Samuel C.; Witt, Abigail E.; Jones, Michelle A.; Wang, Bin; Ince, Tan A. (Public Library of Science, 2013)
      The potential role of the cell-of-origin in determining the tumor phenotype has been raised, but not adequately examined. We hypothesized that distinct cells-of-origin may play a role in determining ovarian tumor phenotype ...

    • Ovarian cancer risk factors by tumor dominance, a surrogate for cell of origin 

      Kotsopoulos, Joanne; Terry, Kathryn Lynne; Poole, Elizabeth M.; Rosner, Bernard Alfred; Murphy, Megan A.; Hecht, Jonathan Lewis; Crum, Christopher Paul; Missmer, Stacey Ann; Cramer, Daniel William; Tworoger, Shelley Slate (Wiley-Blackwell, 2013)
      Differentiating ovarian tumors based on developmental pathway may further our understanding of the disease. Traditionally, ovarian cancers were thought to arise from the ovarian surface epithelium; however, recent evidence ...

    • Peritoneal Dissemination Complicating Morcellation of Uterine Mesenchymal Neoplasms 

      Seidman, Michael A.; Oduyebo, Titilope; Muto, Michael George; Crum, Christopher Paul; Nucci, Marisa Rose; Quade, Bradley Joseph (Public Library of Science, 2012)
      Background: Power morcellation has become a common technique for the minimally invasive resection of uterine leiomyomas. This technique is associated with dissemination of cellular material throughout the peritoneum. When ...

    • Stromal Liver Kinase B1 [STK11] Signaling Loss Induces Oviductal Adenomas and Endometrial Cancer by Activating Mammalian Target of Rapamycin Complex 1 

      Tanwar, Pradeep; Kaneko-Tarui, Tomoko; Zhang, LiHua; Tanaka, Yoshihiro; Crum, Christopher Paul; Teixeira, Jose M. (Public Library of Science, 2012)
      Germline mutations of the Liver Kinase b1 (LKB1/STK11) tumor suppressor gene have been linked to Peutz-Jeghers Syndrome (PJS), an autosomal-dominant, cancer-prone disorder in which patients develop neoplasms in several ...