Browsing by Author "Vasdev, Neil"
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11CO2 Fixation: A Renaissance in PET Radiochemistry
Rotstein, Benjamin H; Liang, Steven; Holland, Jason P; Collier, Thomas L; Hooker, Jacob M; Wilson, Alan A.; Vasdev, Neil (Royal Society of Chemistry, 2013)Carbon-11 labelled carbon dioxide is the cyclotron-generated feedstock reagent for most positron emission tomography (PET) tracers using this radionuclide. Most carbon-11 labels, however, are installed using derivative ... -
Alantolactone selectively ablates acute myeloid leukemia stem and progenitor cells
Ding, Yahui; Gao, Huier; Zhang, Yu; Li, Ye; Vasdev, Neil; Gao, Yingdai; Chen, Yue; Zhang, Quan (BioMed Central, 2016)Background: The poor outcomes for patients diagnosed with acute myeloid leukemia (AML) are largely attributed to leukemia stem cells (LSCs) which are difficult to eliminate with conventional therapy and responsible for ... -
Design and Prototype of an Automated Column-Switching HPLC System for Radiometabolite Analysis
Vasdev, Neil; Collier, Thomas Lee (MDPI, 2016)Column-switching high performance liquid chromatography (HPLC) is extensively used for the critical analysis of radiolabeled ligands and their metabolites in plasma. However, the lack of streamlined apparatus and consequently ... -
PET Imaging of Fatty Acid Amide Hydrolase with [18F]DOPP in Nonhuman Primates
Rotstein, Benjamin H.; Wey, Hsiao-Ying; Shoup, Timothy M.; Wilson, Alan A.; Liang, Steven H.; Hooker, Jacob M.; Vasdev, Neil (American Chemical Society, 2014)Fatty acid amide hydrolase (FAAH) regulates endocannabinoid signaling. [11C]CURB, an irreversibly binding FAAH inhibitor, has been developed for clinical research imaging with PET. However, no fluorine-18 labeled radiotracer ... -
Practical Radiosynthesis and Preclinical Neuroimaging of [11C]isradipine, A Calcium Channel Antagonist
Rotstein, Benjamin H.; Liang, Steven H.; Belov, Vasily V.; Livni, Eli; Levine, Dylan B.; Bonab, Ali A.; Papisov, Mikhail I.; Perlis, Roy H.; Vasdev, Neil (2016)In the interest of developing in vivo positron emission tomography (PET) probes for neuroimaging of calcium channels, we have prepared a carbon-11 isotopologue of a dihydropyridine Ca2+-channel antagonist, isradipine. ... -
Synthesis and Preclinical Evaluation of Sulfonamido-based [11C-Carbonyl]-Carbamates and Ureas for Imaging Monoacylglycerol Lipase
Wang, Lu; Mori, Wakana; Cheng, Ran; Yui, Joji; Hatori, Akiko; Ma, Longle; Zhang, Yiding; Rotstein, Benjamin H.; Fujinaga, Masayuki; Shimoda, Yoko; Yamasaki, Tomoteru; Xie, Lin; Nagai, Yuji; Minamimoto, Takafumi; Higuchi, Makoto; Vasdev, Neil; Zhang, Ming-Rong; Liang, Steven H. (Ivyspring International Publisher, 2016)Monoacylglycerol lipase (MAGL) is a 33 kDa member of the serine hydrolase superfamily that preferentially degrades 2-arachidonoylglycerol (2-AG) to arachidonic acid in the endocannabinoid system. Inhibition of MAGL is not ... -
Synthesis of [ 11 C]Bexarotene by Cu-Mediated [ 11 C]Carbon Dioxide Fixation and Preliminary PET Imaging
Rotstein, Benjamin H; Hooker, Jacob M; Woo, Jiyeon; Collier, Thomas L; Brady, Thomas Joseph; Liang, Steven; Vasdev, Neil (American Chemical Society (ACS), 2014)