Browsing by Author "Burstein, Rami"
Now showing items 1-10 of 10
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Altered Hypothalamic Functional Connectivity with Autonomic Circuits and the Locus Coeruleus in Migraine
Moulton, Eric A.; Becerra, Lino; Johnson, Adriana; Burstein, Rami; Borsook, David (Public Library of Science, 2014)The hypothalamus has been implicated in migraine based on the manifestation of autonomic symptoms with the disease, as well as neuroimaging evidence of hypothalamic activation during attacks. Our objective was to determine ... -
Brain Changes in Responders vs. Non-Responders in Chronic Migraine: Markers of Disease Reversal
Hubbard, Catherine S.; Becerra, Lino; Smith, Jonathan H.; DeLange, Justin M.; Smith, Ryan M.; Black, David F.; Welker, Kirk M.; Burstein, Rami; Cutrer, Fred M.; Borsook, David (Frontiers Media S.A., 2016)The aim of this study was to identify structural and functional brain changes that accompanied the transition from chronic (CM; ≥15 headache days/month) to episodic (EM; <15 headache days/month) migraine following prophylactic ... -
Cortico–Cortical Connections of Primary Sensory Areas and Associated Symptoms in Migraine
Hodkinson, Duncan J.; Veggeberg, Rosanna; Kucyi, Aaron; van Dijk, Koene R. A.; Wilcox, Sophie L.; Scrivani, Steven J.; Burstein, Rami; Becerra, Lino; Borsook, David (Society for Neuroscience, 2016)Abstract Migraine is a recurring, episodic neurological disorder characterized by headache, nausea, vomiting, and sensory disturbances. These events are thought to arise from the activation and sensitization of neurons ... -
Excitatory Neurotransmitters in Brain Regions in Interictal Migraine Patients
Prescot, Andrew; Becerra, Lino Renan; Pendse, Gautam; Tully, Shannon; Jensen, Eric; Hargreaves, Richard; Renshaw, Perry Franklin; Burstein, Rami; Borsook, David (BioMed Central, 2009)Objective: To examine biochemical differences in the anterior cingulate cortex (ACC) and insula during the interictal phase of migraine patients. We hypothesized that there may be differences in levels of excitatory amino ... -
Extracranial injections of botulinum neurotoxin type A inhibit intracranial meningeal nociceptors’ responses to stimulation of TRPV1 and TRPA1 channels: Are we getting closer to solving this puzzle?
Zhang, XiChun; Strassman, Andrew M; Novack, Victor; Brin, Mitchell F; Burstein, Rami (SAGE Publications, 2016)Background: Administration of onabotulinumtoxinA (BoNT-A) to peripheral tissues outside the calvaria reduces the number of days chronic migraine patients experience headache. Because the headache phase of a migraine attack, ... -
Increased Functional Activation of Limbic Brain Regions during Negative Emotional Processing in Migraine
Wilcox, Sophie L.; Veggeberg, Rosanna; Lemme, Jordan; Hodkinson, Duncan J.; Scrivani, Steven; Burstein, Rami; Becerra, Lino; Borsook, David (Frontiers Media S.A., 2016)Pain is both an unpleasant sensory and emotional experience. This is highly relevant in migraine where cortical hyperexcitability in response to sensory stimuli (including pain, light, and sound) has been extensively ... -
Interictal dysfunction of a brainstem descending modulatory center in migraine patients
Tully, Shannon; Hargreaves, Richard; Matsunami, Hiroaki; Moulton, Eric Alan; Burstein, Rami; Becerra, Lino Renan; Borsook, David (Public Library of Science, 2008)Background: The brainstem contains descending circuitry that can modulate nociceptive processing (neural signals associated with pain) in the dorsal horn of the spinal cord and the medullary dorsal horn. In migraineurs, ... -
Neurochemical Pathways That Converge on Thalamic Trigeminovascular Neurons: Potential Substrate for Modulation of Migraine by Sleep, Food Intake, Stress and Anxiety
Noseda, Rodrigo; Kainz, Vanessa; Borsook, David; Burstein, Rami (Public Library of Science, 2014)Dynamic thalamic regulation of sensory signals allows the cortex to adjust better to rapidly changing behavioral, physiological and environmental demands. To fulfill this role, thalamic neurons must themselves be subjected ... -
Primary Somatosensory Cortices Contain Altered Patterns of Regional Cerebral Blood Flow in the Interictal Phase of Migraine
Hodkinson, Duncan J.; Veggeberg, Rosanna; Wilcox, Sophie L.; Scrivani, Steven; Burstein, Rami; Becerra, Lino; Borsook, David (Public Library of Science, 2015)The regulation of cerebral blood flow (CBF) is a complex integrated process that is critical for supporting healthy brain function. Studies have demonstrated a high incidence of alterations in CBF in patients suffering ... -
Sensitization of the Trigeminovascular Pathway: Perspective and Implications to Migraine Pathophysiology
Bernstein, Carolyn A.; Burstein, Rami (Korean Neurological Association, 2012)Migraine headache is commonly associated with signs of exaggerated intracranial and extracranial mechanical sensitivities. Patients exhibiting signs of intracranial hypersensitivity testify that their headache throbs and ...