Browsing by Author "Khurana, Vikram"
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Lysosomal Dysfunction Promotes Cleavage and Neurotoxicity of Tau In Vivo
Khurana, Vikram; Elson-Schwab, Ilan; Fulga, Tudor Alexandru; Sharp, Katherine A.; Loewen, Carin A.; Mulkearns, Erin; Tyynelä, Jaana; Scherzer, Clemens; Feany, Mel B. (Public Library of Science, 2010)Expansion of the lysosomal system, including cathepsin D upregulation, is an early and prominent finding in Alzheimer's disease brain. Cell culture studies, however, have provided differing perspectives on the lysosomal ...