Now showing items 1-20 of 41

    • Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release 

      Ilyinskii, Petr O.; Roy, Christopher J.; O’Neil, Conlin P.; Browning, Erica A.; Pittet, Lynnelle A.; Altreuter, David H.; Alexis, Frank; Tonti, Elena; Shi, Jinjun; Basto, Pamela A.; Iannacone, Matteo; Radovic-Moreno, Aleksandar F.; Langer, Robert S.; Farokhzad, Omid Cameron; von Andrian, Ulrich H.; Johnston, Lloyd P.M.; Kishimoto, Takashi Kei (Elsevier BV, 2014)
      Augmentation of immunogenicity can be achieved by particulate delivery of an antigen and by its co-administration with an adjuvant. However, many adjuvants initiate strong systemic inflammatory reactions in vivo, leading ...
    • Annexin A1–containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair 

      Leoni, Giovanna; Neumann, Philipp-Alexander; Kamaly, Nazila; Quiros, Miguel; Nishio, Hikaru; Jones, Hefin R.; Sumagin, Ronen; Hilgarth, Roland S.; Alam, Ashfaqul; Fredman, Gabrielle; Argyris, Ioannis; Rijcken, Emile; Kusters, Dennis; Reutelingsperger, Chris; Perretti, Mauro; Parkos, Charles A.; Farokhzad, Omid Cameron; Neish, Andrew S.; Nusrat, Asma (American Society for Clinical Investigation, 2015)
      Epithelial restitution is an essential process that is required to repair barrier function at mucosal surfaces following injury. Prolonged breaches in epithelial barrier function result in inflammation and further damage; ...
    • Biofunctionalized targeted nanoparticles for therapeutic applications 

      Wang, Andrew Z; Gu, Frank; Zhang, Liangfang; Chan, Juliana M; Radovic-Moreno, Aleksander; Shaikh, Mariam R; Farokhzad, Omid Cameron (Informa Healthcare, 2008)
      Background: The development of nanoparticles for the delivery of therapeutic agents has introduced new opportunities for improvement in medical treatment. Recent efforts have focused on developing targeted nanoparticles ...
    • Cancer Nanomedicine: From Targeted Delivery to Combination Therapy 

      Xu, Xiaoyang; Ho, William; Zhang, Xueqing; Bertrand, Nicolas; Farokhzad, Omid (2015)
      The advent of nanomedicine marks an unparalleled opportunity to advance the treatment of a variety of diseases, including cancer. The unique properties of nanoparticles, such as large surface-to volume ratio, small size, ...
    • Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology 

      Bertrand, Nicolas; Wu, Jun; Xu, Xiaoyang; Kamaly, Nazila; Farokhzad, Omid Cameron (Elsevier BV, 2014)
      Cancer nanotherapeutics are progressing at a steady rate; research and development in the field has experienced an exponential growth since early 2000’s. The path to the commercialization of oncology drugs is long and ...
    • CD43 gene expression is mediated by a nuclear factor which binds pyrimidine-rich single-stranded DNA 

      Farokhzad, Omid Cameron (Oxford University Press (OUP), 2000)
      CD43 is a leukocyte-specific surface molecule which plays an important role both in adhesion and signal transduction. We have identified a site spanning nucleotides +18 to +39 within the human CD43 gene promoter which in ...
    • ChemoRad nanoparticles: a novel multifunctional nanoparticle platform for targeted delivery of concurrent chemoradiation 

      Wang, Andrew Z; Yuet, Kai; Zhang, Liangfang; Gu, Frank X; Huynh-Le, Minh; Radovic-Moreno, Aleksandar F; Kantoff, Philip Wayne; Bander, Neil H; Langer, Robert S.; Farokhzad, Omid Cameron (Future Medicine Ltd, 2010)
      Aim: The development of chemoradiation – the concurrent administration of chemotherapy and radiotherapy – has led to significant improvements in local tumor control and survival. However, it is limited by its high toxicity. ...
    • Development of Multinuclear Polymeric Nanoparticles as Robust Protein Nanocarriers 

      Wu, Jun; Kamaly, Nazila; Shi, Jinjun; Zhao, Lili; Xiao, Zeyu; Hollett, Geoffrey; John, Rohit; Ray, Shaunak; Xu, Xiaoyang; Zhang, Xueqing; Kantoff, Philip Wayne; Farokhzad, Omid Cameron (Wiley-Blackwell, 2014)
      One limitation of current biodegradable polymeric nanoparticles is their inability to effectively encapsulate and sustainably release proteins while maintaining protein bioactivity. Here we report the engineering of a ...
    • Differentially Charged Hollow Core/Shell Lipid-Polymer-Lipid Hybrid Nanoparticles for Small Interfering RNA Delivery 

      Shi, Jinjun; Xiao, Zeyu; Votruba, Alexander R.; Vilos, Cristian; Farokhzad, Omid Cameron (Wiley-Blackwell, 2011)
      Speedy delivery: Biodegradable and biocompatible polymers and lipids form hybrid core/shell nanoparticles (see picture, left) that show promising in vitro and in vivo results for delivering siRNA. The unique lipid–polymer–lipid ...
    • DNA Self-Assembly of Targeted Near-Infrared-Responsive Gold Nanoparticles for Cancer Thermo-Chemotherapy 

      Xiao, Zeyu; Ji, Changwei; Shi, Jinjun; Pridgen, Eric M; Frieder, Jillian; Farokhzad, Omid Cameron (WILEY-VCH Verlag, 2012)
      Targeted Cancer Therapy: Inspired by the ability of DNA hybridization, a targeted near-infrared (NIR) light-responsive delivery system has been developed through simple DNA self-assembly (PEG=polyethylene glycol). This ...
    • Drug delivery systems in urology—getting “smarter” 

      Farokhzad, Omid Cameron; Dimitrakov, Jordan D.; Karp, Jeffrey MIchael; Khademhosseini, Ali; Freeman, Michael; Langer, Robert S. (Elsevier BV, 2006)
      Urology holds the most enviable position in the medical firmament. Unique among specialties in bringing the surgeon in contact with humans throughout the spectrum of human life—from newborn to geriatric patients—urologists ...
    • Effect of PEG Pairing on the Efficiency of Cancer-Targeting Liposomes 

      Saw, Phei Er; Park, Jinho; Lee, Eunbeol; Ahn, Sukyung; Lee, Jinju; Kim, Hyungjun; Kim, Jinjoo; Choi, Minsuk; Farokhzad, Omid C.; Jon, Sangyong (Ivyspring International Publisher, 2015)
      Standardized poly(ethylene glycol)-modified (PEGylated) liposomes, which have been widely used in research as well as in pre-clinical and clinical studies, are typically constructed using PEG with a molecular weight of ...
    • Effects of ligands with different water solubilities on self-assembly and properties of targeted nanoparticles 

      Valencia, Pedro M.; Hanewich-Hollatz, Mikhail H.; Gao, Weiwei; Karim, Fawziya; Langer, Robert S.; Karnik, Rohit; Farokhzad, Omid Cameron (Elsevier BV, 2011)
      The engineering of drug-encapsulated targeted nanoparticles (NPs) has the potential to revolutionize drug therapy. A major challenge for the smooth translation of targeted NPs to the clinic has been developing methods for ...
    • Emerging nanotechnology approaches for HIV/AIDS treatment and prevention 

      Mamo, Tewodros; Moseman, E Ashley; Kolishetti, Nagesh; Salvador-Morales, Carolina; Shi, Jinjun; Kuritzkes, Daniel Robert; Langer, Robert S.; Andrian, Ulrich von; Farokhzad, Omid Cameron (Future Medicine Ltd, 2010)
      Currently, there is no cure and no preventive vaccine for HIV/AIDS. Combination antiretroviral therapy has dramatically improved treatment, but it has to be taken for a lifetime, has major side effects and is ineffective ...
    • Engineering of lipid-coated PLGA nanoparticles with a tunable payload of diagnostically active nanocrystals for medical imaging 

      Mieszawska, Aneta J.; Gianella, Anita; Cormode, David P.; Zhao, Yiming; Meijerink, Andries; Langer, Robert S.; Farokhzad, Omid Cameron; Fayad, Zahi A.; Mulder, Willem J. M. (Royal Society of Chemistry (RSC), 2012)
      Polylactic-co-glycolic acid (PLGA) based nanoparticles are biocompatible and biodegradable and therefore have been extensively investigated as therapeutic carriers. Here, we engineered diagnostically active PLGA nanoparticles ...
    • Formulation of functionalized PLGA–PEG nanoparticles for in vivo targeted drug delivery 

      Cheng, Jianjun; Teply, Benjamin; Sherifi, Ines; Sung, Josephine; Luther, Gaurav; Gu, Frank; Levy-Nissenbaum, Etgar; Rodovic-Moreno, Aleksandar; Langer, Robert S.; Farokhzad, Omid Cameron (Elsevier BV, 2007)
      Nanoparticle (NP) size has been shown to significantly effect the biodistribution of targeted and non-targeted NPs in an organ specific manner. Herein we have developed NPs from carboxy-terminated poly (d,l-lactide-co-gl ...
    • Formulation/Preparation of Functionalized Nanoparticles for In Vivo Targeted Drug Delivery 

      Gu, Frank; Langer, Robert S.; Farokhzad, Omid Cameron (Springer Science + Business Media, 2009)
      Targeted cancer therapy allows the delivery of therapeutic agents to cancer cells without incurring undesirable side effects on the neighboring healthy tissues. Over the past decade, there has been an increasing interest ...
    • HER-2-Targeted Nanoparticle-Affibody Bioconjugates for Cancer Therapy 

      Alexis, Frank; Basto, Pamela; Levy-Nissenbaum, Etgar; Radovic-Moreno, Aleksandar F.; Zhang, Liangfang; Pridgen, Eric; Wang, Andrew Z.; Marein, Shawn L.; Westerhof, Katrina; Molnar, Linda K.; Farokhzad, Omid Cameron (Wiley-Blackwell, 2008)
      Affibodies are a class of polypeptide ligands that are potential candidates for cell- or tissue-specific targeting of drug-encapsulated controlled release polymeric nanoparticles (NPs). Here we report the development of ...
    • Hybrid lipid–polymer nanoparticles for sustained siRNA delivery and gene silencing 

      Shi, Jinjun; Xu, Yingjie; Xu, Xiaoyang; Zhu, Xi; Pridgen, Eric; Wu, Jun; Votruba, Alexander R.; Swami, Archana; Zetter, Bruce Robert; Farokhzad, Omid Cameron (Elsevier BV, 2014)
      The development of controlled-release nanoparticle (NP) technologies has great potential to further improve the therapeutic efficacy of RNA interference (RNAi), by prolonging the release of small interfering RNA (siRNA) ...
    • Immunocompatibility properties of lipid–polymer hybrid nanoparticles with heterogeneous surface functional groups 

      Salvador-Morales, Carolina; Zhang, Liangfang; Langer, Robert S.; Farokhzad, Omid Cameron (Elsevier BV, 2009)
      Here we report the immunological characterization of lipid-polymer hybrid nanoparticles (NPs) and propose a method to control the levels of complement activation induced by these NPs. This method consists of the highly ...