Browsing by Author "Thanos, Aristomenis"
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AMP-activated Protein Kinase Suppresses Matrix Metalloproteinase-9 Expression in Mouse Embryonic Fibroblasts
Morizane, Y.; Thanos, Aristomenis; Takeuchi, K.; Murakami, Y.; Kayama, M.; Trichonas, G.; Miller, Joan Whitten; Foretz, M.; Viollet, B.; Vavvas, Demetrios (American Society for Biochemistry & Molecular Biology (ASBMB), 2011)Matrix metalloproteinase-9 (MMP-9) plays a critical role in tissue remodeling under both physiological and pathological conditions. Although MMP-9 expression is low in most cells and is tightly controlled, the mechanism ... -
Choroidal Neovascular Membrane Formation and Retinochoroidopathy in a Patient with Systemic Langerhans Cell Histiocytosis: A Case Report and Review of the Literature
Thanos, Aristomenis; Vavvas, Demetrios; Young, Lucy Hwa-Yue; Foster, Charles Stephen (S. Karger AG, 2012)We report a case of bilateral atrophic retinochoroidopathy with choroidal neovascular membrane (CNVM) formation in a patient with systemic Langerhans cell histiocytosis (LCH). A 35-year-old female, diagnosed with LCH at ... -
Etanercept, a Widely Used Inhibitor of Tumor Necrosis Factor-α (TNF- α), Prevents Retinal Ganglion Cell Loss in a Rat Model of Glaucoma
Roh, Miin; Zhang, Yan; Murakami, Yusuke; Thanos, Aristomenis; Lee, Sung Chul; Vavvas, Demetrios; Benowitz, Larry Ira; Miller, Joan Whitten (Public Library of Science, 2012)Background: Visual loss in glaucoma is associated with pathological changes in retinal ganglion cell (RGC) axons and a slow decline in the RGC population. Age and elevated intraocular pressure (IOP) are the main risk factors ... -
Evidence for Baseline Retinal Pigment Epithelium Pathology in the Trp1-Cre Mouse
Thanos, Aristomenis; Morizane, Yuki; Murakami, Yusuke; Giani, Andrea; Mantopoulos, Dimosthenis; Kayama, Maki; Roh, Mi In; Michaud, Norman; Pawlyk, Basil; Sandberg, Michael Arthur; Young, Lucy Hwa-Yue; Miller, Joan Whitten; Vavvas, Demetrios (Elsevier BV, 2012)The increasing popularity of the Cre/loxP recombination system has led to the generation of numerous transgenic mouse lines in which Cre recombinase is expressed under the control of organ- or cell-specific promoters. ... -
Mechanisms of Inflammation in Proliferative Vitreoretinopathy: From Bench to Bedside
Moysidis, Stavros N.; Thanos, Aristomenis; Vavvas, Demetrios (Hindawi Publishing Corporation, 2012)Proliferative vitreoretinopathy (PVR) is a vision-threatening disease and a common complication of surgery to correct rhegmatogenous retinal detachment (RRD). Several models of the pathogenesis of this disease have been ... -
Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration
Murakami, Y; Matsumoto, Hidetaka; Roh, Mi In; Giani, A; Kataoka, Keiko; Morizane, Y; Kayama, M; Thanos, Aristomenis; Nakatake, S; Notomi, S; Hisatomi, T; Ikeda, Y; Ishibashi, T; Connor, K M; Miller, Joan Whitten; Vavvas, Demetrios (Springer Nature, 2013)There is no known treatment for the dry form of an age-related macular degeneration (AMD). Cell death and inflammation are important biological processes thought to have central role in AMD. Here we show that receptor-interacting ... -
Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis
Trichonas, G.; Murakami, Y.; Thanos, Aristomenis; Morizane, Y.; Kayama, M.; Debouck, C. M.; Hisatomi, T.; Miller, Joan Whitten; Vavvas, Demetrios (Proceedings of the National Academy of Sciences, 2010)Apoptosis has been shown to be a significant form of cell loss in many diseases. Detachment of photoreceptors from the retinal pigment epithelium, as seen in various retinal disorders, causes photoreceptor loss and subsequent ... -
Therapeutic Interventions against Inflammatory and Angiogenic Mediators in Proliferative Diabetic Retinopathy
Gologorsky, Daniel; Thanos, Aristomenis; Vavvas, Demetrios (Hindawi Publishing Corporation, 2012)The global prevalence of diabetes is estimated to be 336 million people, with diabetic complications contributing to significant worldwide morbidity and mortality. Diabetic retinopathy results from cumulative microvascular ...