Browsing by Author "Hayakawa, Kazuhide"

Now showing items 1-6 of 6

    • CD200 increases alternatively activated macrophages through cAMP-response element binding protein - C/EBP-beta signaling 

      Hayakawa, Kazuhide; Wang, Xiaohua; Lo, Eng H. (Wiley, 2016)
      The concept of macrophage polarization toward different phenotypes after CNS injury has been increasingly discussed. Here, we propose that CD200 treatment may help shift pro-inflammatory macrophages to an arginase 1 (Arg1)-, ...

    • CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation 

      Hayakawa, Kazuhide; Pham, Loc-Duyen; Seo, Ji-Hae; Miyamoto, Nobukazu; Maki, Takakuni; Sakadzic, Sava; Boas, David A.; van Leyen, Klaus J.; Waeber, Christian; Kim, Kyu-Won; Arai, Ken; Lo, Eng H. (SAGE Publications, 2016)
      There are numerous barriers to white matter repair after CNS injury and the underlying mechanisms remain to be fully understood. In this study, we propose the hypothesis that inflammatory macrophages in damaged white matter ...

    • Neuroglobin-overexpression reduces traumatic brain lesion size in mice 

      Zhao, Song; Yu, Zhanyang; Xing, Changhong; Hayakawa, Kazuhide; Whalen, Michael Jerome; Lok, Josephine M.; Lo, Eng H.; Wang, Xiaoying (BioMed Central, 2012)
      Background: Accumulating evidence has demonstrated that over-expression of Neuroglobin (Ngb) is neuroprotective against hypoxic/ischemic brain injuries. In this study we tested the neuroprotective effects of Ngb over-expression ...

    • Oligodendrocyte Precursor Cells Support Blood-Brain Barrier Integrity via TGF-β Signaling 

      Seo, Ji Hae; Maki, Takakuni; Maeda, Mitsuyo; Miyamoto, Nobukazu; Liang, Anna C.; Hayakawa, Kazuhide; Pham, Loc-Duyen D.; Suwa, Fumihiko; Taguchi, Akihiko; Matsuyama, Tomohiro; Ihara, Masafumi; Kim, Kyu-Won; Lo, Eng H.; Arai, Ken (Public Library of Science, 2014)
      Trophic coupling between cerebral endothelium and their neighboring cells is required for the development and maintenance of blood-brain barrier (BBB) function. Here we report that oligodendrocyte precursor cells (OPCs) ...

    • Potential Circadian Effects on Translational Failure for Neuroprotection 

      Esposito, Elga; Li, Wenlu; Mandeville, Emiri; Park, Ji-Hyun; Sencan, Ikbal; Guo, Shuzhen; Shi, Jingfei; Lan, Jing; Lee, Janice; Hayakawa, Kazuhide; Sakadzic, Sava; Ji, Xunming; Lo, Eng (Springer Science and Business Media LLC, 2020-06-03)
      Neuroprotectant strategies that have worked in rodent models of stroke have failed to provide protection in clinical trials. Here we show that the opposite circadian cycles in nocturnal rodents versus diurnal humans may ...

    • Transfer of mitochondria from astrocytes to neurons after stroke 

      Hayakawa, Kazuhide; Esposito, Elga; Wang, Xiaohua; Terasaki, Yasukazu; Liu, Yi; Xing, Changhong; Ji, Xunming; Lo, Eng H. (2016)
      Recently, it was suggested that neurons can release and transfer damaged mitochondria to astrocytes for disposal and recycling 1. This ability to exchange mitochondria may represent a potential mode of cell-cell signaling ...