Now showing items 1-7 of 7

    • Connectomes across development reveal principles of brain maturation 

      Witvliet, Daniel; Mulcahy, Ben; Mitchell, James; Meirovitch, Yaron; Berger, Daniel; Wu, Yuelong; Liu, Yufang; Koh, Wan Xian; Parvathala, Rajeev; Holmyard, Douglas; Schalek, Richard; Shavit, Nir; Chisholm, Andrew; Lichtman, Jeff; Samuel, Aravi; Zhen, Mei (Cold Spring Harbor Laboratory, 2020-04-30)
      From birth to adulthood, an animal’s nervous system changes as its body grows and its behaviours mature. The form and extent of circuit remodelling across the connectome is unknown. We used serial-section electron microscopy ...
    • Connexin43 Inhibition Prevents Human Vein Grafts Intimal Hyperplasia 

      Longchamp, Alban; Allagnat, Florent; Alonso, Florian; Kuppler, Christopher; Dubuis, Céline; Ozaki, Charles-Keith; Mitchell, James R.; Berceli, Scott; Corpataux, Jean-Marc; Déglise, Sébastien; Haefliger, Jacques-Antoine (Public Library of Science, 2015)
      Venous bypass grafts often fail following arterial implantation due to excessive smooth muscle cells (VSMC) proliferation and consequent intimal hyperplasia (IH). Intercellular communication mediated by Connexins (Cx) ...
    • Dietary restriction protects against experimental cerebral malaria via leptin modulation and T cell mTORC1 suppression 

      Mejia, Pedro; Treviño-Villarreal, J. Humberto; Hine, Christopher; Harputlugil, Eylul; Lang, Samantha; Calay, Ediz; Rogers, Rick; Wirth, Dyann; Duraisingh, Manoj T.; Mitchell, James R. (2014)
      Host nutrition can affect the outcome of parasitic diseases through metabolic effects on host immunity and/or the parasite. Here we show that modulation of mouse immunometabolism through brief restriction of food intake ...
    • The First International Mini-Symposium on Methionine Restriction and Lifespan 

      Ables, Gene P.; Brown-Borg, Holly M.; Buffenstein, Rochelle; Church, Christopher D.; Elshorbagy, Amany K.; Gladyshev, Vadim N.; Huang, Tsang-hai; Miller, Richard A.; Mitchell, James R.; Richie, John P.; Rogina, Blanka; Stipanuk, Martha H.; Orentreich, David S.; Orentreich, Norman (Frontiers Media S.A., 2014)
      It has been 20 years since the Orentreich Foundation for the Advancement of Science, under the leadership Dr. Norman Orentreich, first reported that low methionine (Met) ingestion by rats extends lifespan (Orentreich et ...
    • Interventions to Slow Aging in Humans: Are We Ready? 

      Longo, Valter D; Antebi, Adam; Bartke, Andrzej; Barzilai, Nir; Brown-Borg, Holly M; Caruso, Calogero; Curiel, Tyler J; de Cabo, Rafael; Franceschi, Claudio; Gems, David; Ingram, Donald K; Johnson, Thomas E; Kennedy, Brian K; Kenyon, Cynthia; Klein, Samuel; Kopchick, John J; Lepperdinger, Guenter; Madeo, Frank; Mirisola, Mario G; Mitchell, James R; Passarino, Giuseppe; Rudolph, Karl L; Sedivy, John M; Shadel, Gerald S; Sinclair, David A; Spindler, Stephen R; Suh, Yousin; Vijg, Jan; Vinciguerra, Manlio; Fontana, Luigi (John Wiley & Sons, Ltd, 2015)
      The workshop entitled ‘Interventions to Slow Aging in Humans: Are We Ready?’ was held in Erice, Italy, on October 8–13, 2013, to bring together leading experts in the biology and genetics of aging and obtain a consensus ...
    • Microbiome-Targeted Interventions for Colitis-Associated Bacteria 

      Rooks, Michelle Gabrielle (2016-05-06)
      Complex interactions between mammalian hosts and their gut microbes have evolved over many millennia and have established a sophisticated communication system that is essential for symbiosis and mutualism. Perturbations ...
    • Short-term Preoperative Dietary Restriction Is Neuroprotective in a Rat Focal Stroke Model 

      Varendi, Kärt; Airavaara, Mikko; Anttila, Jenni; Vose, Sarah; Planken, Anu; Saarma, Mart; Mitchell, James R.; Andressoo, Jaan-Olle (Public Library of Science, 2014)
      Stroke is a major complication of cardiovascular surgery, resulting in over 100,000 deaths and over a million postoperative encephalopathies annually in the US and Europe. While mitigating damage from stroke after it occurs ...