Browsing by Author "Groopman, Jerome"
Now showing items 1-7 of 7
-
Activation of the Connective Tissue Growth Factor (CTGF)-Transforming Growth Factor β 1 (TGF-β 1) Axis in Hepatitis C Virus-Expressing Hepatocytes
Nagaraja, Tirumuru; Chen, Li; Balasubramanian, Anuradha; Groopman, Jerome Elliot; Ghoshal, Kalpana; Jacob, Samson T.; Leask, Andrew; Brigstock, David R.; Anand, Appakkudal R.; Ganju, Ramesh K. (Public Library of Science, 2012)Background: The pro-fibrogenic cytokine connective tissue growth factor (CTGF) plays an important role in the development and progression of fibrosis in many organ systems, including liver. However, its role in the ... -
Cocaine Enhances DC to T-cell HIV-1 Transmission by Activating DC-SIGN/LARG/LSP1 Complex and Facilitating Infectious Synapse Formation
Prasad, Anil; Kulkarni, Rutuja; Jiang, Shuxian; Groopman, Jerome E. (Nature Publishing Group, 2017)DC-SIGN is a dendritic cell surface structure which participates in binding and transmission of HIV-1. Here, for the first time we demonstrate that cocaine induces over expression of DC-SIGN and significantly enhances virus ... -
Cocaine enhances HIV-1 gp120-induced lymphatic endothelial dysfunction in the lung
Zhang, Xuefeng; Jiang, Susan; Yu, Jinlong; Kuzontkoski, Paula M; Groopman, Jerome E (John Wiley & Sons, Ltd, 2015)Pulmonary complications are common in both AIDS patients and cocaine users. We addressed the cellular and molecular mechanisms by which HIV and cocaine may partner to induce their deleterious effects. Using primary lung ... -
Slit2/Robo4 Signaling Modulates HIV-1 gp120-Induced Lymphatic Hyperpermeability
Zhang, Xeufeng; Yu, JinLong; Kuzontkoski, Paula Marie; Zhu, Weiquan; Li, Dean Y.; Groopman, Jerome Elliot (Public Library of Science, 2012)Dissemination of HIV in the host involves transit of the virus and virus-infected cells across the lymphatic endothelium. HIV may alter lymphatic endothelial permeability to foster dissemination, but the mechanism is largely ... -
Slit2N and Robo4 regulate lymphangiogenesis through the VEGF-C/VEGFR-3 pathway
Yu, Jinlong; Zhang, Xuefeng; Kuzontkoski, Paula M; Jiang, Shuxian; Zhu, Weiquan; Li, Dean Y; Groopman, Jerome E (BioMed Central, 2014)Background: Signaling through vascular endothelial growth factor C (VEGF–C) and VEGF receptor 3 (VEGFR-3) plays a central role in lymphangiogenesis and the metastasis of several cancers via the lymphatics. Recently, the ... -
Slit2N Inhibits Transmission of HIV-1 from Dendritic Cells to T-cells by Modulating Novel Cytoskeletal Elements
Shrivastava, Ashutosh; Prasad, Anil; Kuzontkoski, Paula M.; Yu, Jinlong; Groopman, Jerome E. (Nature Publishing Group, 2015)Dendritic cells are among the first cells to encounter sexually acquired human immunodeficiency virus (HIV-1), in the mucosa, and they can transmit HIV-1 to CD4+ T-cells via an infectious synapse. Recent studies reveal ... -
Slit2N/Robo1 Inhibit HIV-gp120-Induced Migration and Podosome Formation in Immature Dendritic Cells by Sequestering LSP1 and WASp
Prasad, Anil; Kuzontkoski, Paula Marie; Shrivastava, Ashutosh; Zhu, Weiquan; Li, Dean Y.; Groopman, Jerome Elliot (Public Library of Science, 2012)Cell-mediated transmission and dissemination of sexually-acquired human immunodeficiency virus 1 (HIV-1) in the host involves the migration of immature dendritic cells (iDCs). iDCs migrate in response to the HIV-1 envelope ...