Browsing by Author "Bakshi, Rohit"
Now showing items 1-20 of 24
-
A 3T MR Imaging Investigation of the Topography of Whole Spinal Cord Atrophy in Multiple Sclerosis
Klein, Joshua Peter; Arora, A.; Neema, M; Healy, Brian Curran; Tauhid, Shahamat Syed; Goldberg-Zimring, D.; Chavarro-Nieto, C.; Stankiewicz, James; Cohen, Adam Brian; Buckle, G. J.; Houtchens, Maria K.; Ceccarelli, A.; Dell, E.; Guttmann, Charles R.G.; Alsop, David C.; Hackney, David Brian; Bakshi, Rohit (American Society of Neuroradiology (ASNR), 2011)Background and Purpose: Spinal cord atrophy is a common feature of MS. However, it is unknown which cord levels are most susceptible to atrophy. We performed whole cord imaging to identify the levels most susceptible to ... -
3 T MRI relaxometry detects T2 prolongation in the cerebral normal-appearing white matter in multiple sclerosis
Neema, Mohit; Goldberg-Zimring, Daniel; Guss, Zachary D.; Healy, Brian; Guttmann, Charles; Houtchens, Maria; Weiner, Howard; Horsfield, Mark A.; Hackney, David; Alsop, David; Bakshi, Rohit (Elsevier BV, 2009-07-01)MRI at 3 T has increased sensitivity in detecting overt multiple sclerosis (MS) brain lesions; a growing body of data suggests clinically relevant damage occurs in the normal-appearing white matter (NAWM). We tested a novel ... -
Brain MRI Lesion Load at 1.5T and 3T versus Clinical Status in Multiple Sclerosis
Stankiewicz, James; Glanz, Bonnie; Healy, Brian Curran; Arora, Ashish; Neema, Mohit; Benedict, Ralph H.B.; Guss, Zachary D.; Tauhid, Shahamat Syed; Buckle, Guy J.; Houtchens, Maria K.; Khoury, Samia Joseph; Weiner, Howard Lee; Guttmann, Charles R.G.; Bakshi, Rohit (Wiley-Blackwell, 2011)Background/Purpose: To assess correlation between brain lesions and clinical status with 1.5T and 3T magnetic resonance imaging (MRI). Methods: Brain MRI fluid-attenuated inversion-recovery (FLAIR) sequences were performed ... -
Brain MRI lesions and atrophy are associated with employment status in patients with multiple sclerosis
Tauhid, Shahamat; Chu, Renxin; Sasane, Rahul; Glanz, Bonnie I.; Neema, Mohit; Miller, Jennifer R.; Kim, Gloria; Signorovitch, James E.; Healy, Brian C.; Chitnis, Tanuja; Weiner, Howard L.; Bakshi, Rohit (Springer Berlin Heidelberg, 2015)Multiple sclerosis (MS) commonly affects occupational function. We investigated the link between brain MRI and employment status. Patients with MS (n = 100) completed a Work Productivity and Activity Impairment (WPAI) ... -
The Contribution of Cortical Lesions to a Composite MRI Scale of Disease Severity in Multiple Sclerosis
Yousuf, Fawad; Kim, Gloria; Tauhid, Shahamat; Glanz, Bonnie I.; Chu, Renxin; Tummala, Subhash; Healy, Brian C.; Bakshi, Rohit (Frontiers Media S.A., 2016)Objective: To test a new version of the Magnetic Resonance Disease Severity Scale (v.3 = MRDSS3) for multiple sclerosis (MS), incorporating cortical gray matter lesions (CLs) from 3T magnetic resonance imaging (MRI). ... -
The Effect of Dimethyl Fumarate on Cerebral Gray Matter Atrophy in Multiple Sclerosis
Dupuy, Sheena L.; Tauhid, Shahamat; Hurwitz, Shelley; Chu, Renxin; Yousuf, Fawad; Bakshi, Rohit (Springer Healthcare, 2016)Introduction: The objective of this pilot study was to compare cerebral gray matter (GM) atrophy over 1 year in patients starting dimethyl fumarate (DMF) for multiple sclerosis (MS) to that of patients on no disease-modifying ... -
The Effect of Fingolimod on Conversion of Acute Gadolinium-Enhancing Lesions to Chronic T1 Hypointensities in Multiple Sclerosis
Oommen Vinit, V; Tauhid, Shahamat; Healy Brian, C; Chua Alicia, S; Malik, MT; Diaz-Cruz, Camilo; Dupuy Sheena, L; Weiner Howard, L; Chitnis, Tanuja; Bakshi, Rohit (Wiley-Blackwell, 2015)BACKGROUND: Brain lesions converting to chronic T1 hypointensities (“chronic black holes” [CBH]), indicate severe tissue destruction (axonal loss and irreversible demyelination) in multiple sclerosis (MS). Two mechanisms ... -
The effect of intramuscular interferon beta-1a on spinal cord volume in relapsing-remitting multiple sclerosis
Dupuy, Sheena L.; Khalid, Fariha; Healy, Brian C.; Bakshi, Sonya; Neema, Mohit; Tauhid, Shahamat; Bakshi, Rohit (BioMed Central, 2016)Background: Spinal cord atrophy occurs early in multiple sclerosis (MS) and impacts disability. The therapeutic effect of interferon beta-1a (IFNβ-1a) on spinal cord atrophy in patients with relapsing-remitting (RR) MS has ... -
An expanded composite scale of MRI-defined disease severity in multiple sclerosis: MRDSS2
Bakshi, Rohit; Neema, Mohit; Tauhid, Shahamat; Healy, Brian C.; Glanz, Bonnie I.; Kim, Gloria; Miller, Jennifer; Berkowitz, Julia L.; Bove, Riley; Houtchens, Maria K.; Severson, Christopher; Stankiewicz, James M.; Stazzone, Lynn; Chitnis, Tanuja; Guttmann, Charles R.G.; Weiner, Howard L.; Ceccarelli, Antonia (Lippincott Williams & Wilkins, 2014)The objective of this study was to test a new version of the Magnetic Resonance Disease Severity Scale (MRDSS2), incorporating cerebral gray matter (GM) and spinal cord involvement from 3 T MRI, in modeling the relationship ... -
Fludarabine add-on therapy in interferon-beta-treated patients with multiple sclerosis experiencing breakthrough disease
Greenberg, Steven A.; Zivadinov, R.; Lee-Kwen, P.; Sharma, Jitendra; Planter, M.; Umhauer, M.; Glenister, N.; Bakshi, Rohit (SAGE Publications, 2016)Background: Patients with relapsing–remitting multiple sclerosis (RRMS) may experience breakthrough disease despite effective interferon beta (IFNβ) therapy. Fludarabine (FLU) is a chemotherapeutic agent used in ... -
Handling changes in MRI acquisition parameters in modeling whole brain lesion volume and atrophy data in multiple sclerosis subjects: Comparison of linear mixed-effect models
Chua, Alicia S.; Egorova, Svetlana; Anderson, Mark C.; Polgar-Turcsanyi, Mariann; Chitnis, Tanuja; Weiner, Howard L.; Guttmann, Charles R.G.; Bakshi, Rohit; Healy, Brian C. (Elsevier, 2015)Magnetic resonance imaging (MRI) of the brain provides important outcome measures in the longitudinal evaluation of disease activity and progression in MS subjects. Two common measures derived from brain MRI scans are the ... -
Identification and Clinical Impact of Multiple Sclerosis Cortical Lesions as Assessed by Routine 3T MR Imaging
Mike, A.; Glanz, Bonnie; Hildenbrand, Peter G.; Meier, D; Bolden, K.; Liguori, M.; Dell, E.; Healy, Brian Curran; Bakshi, Rohit; Guttmann, Charles R.G. (American Society of Neuroradiology (ASNR), 2011)Background and Purpose: Histopathologic studies have reported widespread cortical lesions in MS; however, in vivo detection by using routinely available pulse sequences is challenging. We investigated the relative frequency ... -
The Impact of Lesion In-Painting and Registration Methods on Voxel-Based Morphometry in Detecting Regional Cerebral Gray Matter Atrophy in Multiple Sclerosis
Ceccarelli, A.; Jackson, J. S.; Tauhid, S.; Arora, A; Gorky, J.; Dell, E.; Bakshi, A.; Chitnis, Tanuja; Khoury, Samia Joseph; Weiner, Howard Lee; Guttmann, Charles R.G.; Bakshi, Rohit; Neema, Mohit (American Society of Neuroradiology (ASNR), 2012)Background and Purpose: VBM has been widely used to study GM atrophy in MS. MS lesions lead to segmentation and registration errors that may affect the reliability of VBM results. Improved segmentation and registration ... -
Microstructural Changes in the Striatum and Their Impact on Motor and Neuropsychological Performance in Patients with Multiple Sclerosis
Cavallari, Michele; Ceccarelli, Antonia; Wang, Guang-Yi; Moscufo, Nicola; Hannoun, Salem; Matulis, Christina R.; Jackson, Jonathan S.; Glanz, Bonnie I.; Bakshi, Rohit; Neema, Mohit; Guttmann, Charles R. G. (Public Library of Science, 2014)Grey matter (GM) damage is a clinically relevant feature of multiple sclerosis (MS) that has been previously assessed with diffusion tensor imaging (DTI). Fractional anisotropy (FA) of the basal ganglia and thalamus might ... -
MRI detection of hypointense brain lesions in patients with multiple sclerosis: T1 spin-echo vs. gradient-echo
Dupuy, Sheena; Tauhid, Shahamat Syed; Kim, Gloria; Chu, Renxin; Tummala, Subhash; Hurwitz, Shelley; Bakshi, Rohit (Elsevier BV, 2015)Objective Compare T1 spin-echo (T1SE) and T1 gradient-echo (T1GE) sequences in detecting hypointense brain lesions in multiple sclerosis (MS). Background Chronic hypointense lesions on T1SE MRI scans are a surrogate ... -
MRI phenotypes based on cerebral lesions and atrophy in patients with multiple sclerosis
Tauhid, Shahamat Syed; Neema, Mohit; Healy, Brian Curran; Weiner, Howard Lee; Bakshi, Rohit (Elsevier BV, 2014)Background: While disease categories (i.e. clinical phenotypes) of multiple sclerosis (MS) are established, there remains MRI heterogeneity among patients within those definitions. MRI-defined lesions and atrophy show only ... -
An MRI-defined measure of cerebral lesion severity to assess therapeutic effects in multiple sclerosis
Kim, Gloria; Tauhid, Shahamat; Dupuy, Sheena L.; Tummala, Subhash; Khalid, Fariha; Healy, Brian C.; Bakshi, Rohit (Springer Berlin Heidelberg, 2016)Assess the sensitivity of the Magnetic Resonance Disease Severity Scale (MRDSS), based on cerebral lesions and atrophy, for treatment monitoring of glatiramer acetate (GA) in relapsing-remitting multiple sclerosis (MS). ... -
Normal Findings on Brain Fluid-Attenuated Inversion Recovery MR Images at 3T
Neema, M; Guss, Z.D.; Stankiewicz, James; Arora, A; Healy, Brian Curran; Bakshi, Rohit (American Society of Neuroradiology (ASNR), 2009)Background and Purpose: Fluid attenuated inversion recovery (FLAIR) MR imaging of the brain has become a routine tool for assessing lesions in patients with suspected neurologic disorders. There is growing interest in 3T ... -
Quantification of Global Cerebral Atrophy in Multiple Sclerosis from 3T MRI Using SPM: The Role of Misclassification Errors
Dell’Oglio, Elisa; Ceccarelli, Antonia; Glanz, Bonnie I; Healy, Brian C; Tauhid, Shahamat; Arora, Ashish; Saravanan, Nikila; Bruha, Matthew J; Vartanian, Alexander V; Dupuy, Sheena L; Benedict, Ralph HB; Bakshi, Rohit; Neema, Mohit (BlackWell Publishing Ltd, 2014)Purpose We tested the validity of a freely available segmentation pipeline to measure compartmental brain volumes from 3T MRI in patients with multiple sclerosis (MS). Our primary focus was methodological to explore the ... -
The Relationships among MRI-Defined Spinal Cord Involvement, Brain Involvement, and Disability in Multiple Sclerosis
Cohen, Adam B.; Neema, Mohit; Arora, Ashish; Dell’Oglio, Elisa; Benedict, Ralph H. B.; Tauhid, Shahamat; Goldberg-Zimring, Daniel; Chavarro-Nieto, Christian; Ceccarelli, Antonella; Klein, Joshua; Stankiewicz, James M.; Houtchens, Maria; Buckle, Guy J.; Alsop, David; Guttmann, Charles; Bakshi, Rohit (Wiley, 2012-04)Objective To determine the inter-relationships between MRI-defined lesion and atrophy measures of spinal cord involvement and brain involvement and their relationships to disability in a small cohort of patients with ...