Browsing by Author "Rabkin, Samuel"
Now showing items 1-10 of 10
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Cancer Stem Cell-Like Cells Derived from Malignant Peripheral Nerve Sheath Tumors
Spyra, Melanie; Kluwe, Lan; Hagel, Christian; Nguyen, Rosalyn T.; Panse, Jens; Kurtz, Andreas; Mautner, Victor Felix; Rabkin, Samuel David; Demestre, Maria (Public Library of Science, 2011)This study aims to examine whether or not cancer stem cells exist in malignant peripheral nerve sheath tumors (MPNST). Cells of established lines, primary cultures and freshly dissected tumors were cultured in serum free ... -
Combination of vinblastine and oncolytic herpes simplex virus vector expressing IL-12 therapy increases antitumor and antiangiogenic effects in prostate cancer models
Passer, Brent J.; Cheema, Tooba; Wu, Shulin; Wu, Chen-lee; Rabkin, Samuel D.; Martuza, Robert L. (2013)Oncolytic herpes simplex virus-1 (oHSV)–based vectors selectively replicate in tumor cells causing direct killing, ie., oncolysis, while sparing normal cells. oHSV’sare promising anticancer agents, but their efficacy, when ... -
Designing herpes viruses as oncolytics
Peters, Cole; Rabkin, Samuel D (Nature Publishing Group, 2015)Oncolytic herpes simplex virus (oHSV) was one of the first genetically-engineered oncolytic viruses. Because HSV is a natural human pathogen that can cause serious disease, it is incumbent that it can be genetically-engineered ... -
Flip-Flop HSV-BAC: Bacterial Artificial Chromosome Based System for Rapid Generation of Recombinant Herpes Simplex Virus Vectors Using Two Independent Site-specific Recombinases
Kuroda, Toshihiko; Martuza, Robert Lawrence; Todo, Tomoki; Rabkin, Samuel David (BioMed Central, 2006)Background: Oncolytic herpes simplex virus (HSV) vectors that specifically replicate in and kill tumor cells sparing normal cells are a promising cancer therapy. Traditionally, recombinant HSV vectors have been generated ... -
Immunovirotherapy for the treatment of glioblastoma
Cheema, Tooba A; Fecci, Peter E; Ning, Jianfang; Rabkin, Samuel D (Landes Bioscience, 2014)We have recently described a new murine model of glioblastoma, generated by the implantation of syngeneic glioblastoma stem cells into immunocompetent mice, that recapitulates the salient histopathological and immunological ... -
Oncolytic viruses on the cusp of success?: proceedings of the 9th International Conference on Oncolytic Virus Therapeutics
Peters, Cole; Nigim, Fares; Chiocca, E Antonio; Rabkin, Samuel D (Nature Publishing Group, 2016)Boston, Massachusetts, was the site of the 9th International Conference on Oncolytic Virus Therapeutics held 13–16 June 2015. An overarching theme of the meeting was the continued development of combinatorial treatment ... -
Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells
Suva, Mario Luca; Rheinbay, Esther; Gillespie, Shawn M.; Patel, Anoop Premswaroop; Wakimoto, Hiroaki; Rabkin, Samuel David; Riggi, Nicolo; Chi, Anthony Wei Shine; Cahill, Daniel P.; Nahed, Brian Vala; Curry, William Thomas; Martuza, Robert Lawrence; Rivera, Miguel Nicolas; Rossetti, Nikki; Kasif, Simon; Beik, Samantha Petrillo; Kadri, Sabah; Tirosh, Itay; Wortman, Ivo; Shalek, Alex K.; Rozenblatt-Rosen, Orit; Regev, Aviv; Louis, David N.; Bernstein, Bradley E. (Elsevier BV, 2014)Developmental fate decisions are dictated by master transcription factors (TFs) that interact with cis-regulatory elements to direct transcriptional programs. Certain malignant tumors may also depend on cellular hierarchies ... -
Treatment of breast cancer stem cells with oncolytic herpes simplex virus
Li, J.; Zeng, W.; Zhang, Q.; Hu, P; Rabkin, Samuel David; Liu, R. (Nature Publishing Group, 2012)Cancer stem cells have recently been isolated from several different solid tumors. In breast cancer, the \(CD44^{+} CD24^{−/low}\) population is considered to comprise stem-like cells. The identification of cancer stem ... -
Treatment of human hepatocellular carcinoma by the oncolytic herpes simplex virus G47delta
Wang, Jiani; Xu, Lihua; Zeng, Weigen; Hu, Pan; Zeng, Musheng; Rabkin, Samuel D; Liu, Renbin (BioMed Central, 2014)Background: Oncolytic herpes simplex virus (HSV) can replicate in and kill cancer cells while sparing the adjacent normal tissue. Hepatocellular carcinoma (HCC) is amongst the most common and lethal cancers, especially in ... -
TRIM27 in HSV-1 Infection: A Story of Loss and Death
Conwell, Sara (2015-04-21)During viral infection, the host subjects the virus to an array of protective mechanisms. Viruses have evolved evasion strategies to thwart these defenses, and must simultaneously regulate multiple cellular pathways and ...